Results 21 to 30 of about 197,132 (159)

The role of protein acetylation in carcinogenesis and targeted drug discovery

Frontiers in Endocrinology, 2022
Protein acetylation is a reversible post-translational modification, and is involved in many biological processes in cells, such as transcriptional regulation, DNA damage repair, and energy metabolism, which is an important molecular event and is ...
Jingru Yang, Jingru Yang, Cong Song, Xianquan Zhan, Xianquan Zhan   +4 more
doaj   +1 more source

Conserved Lysine Acetylation within the Microtubule-Binding Domain Regulates MAP2/Tau Family Members. [PDF]

PLoS ONE, 2016
Lysine acetylation has emerged as a dominant post-translational modification (PTM) regulating tau proteins in Alzheimer's disease (AD) and related tauopathies.
Andrew W Hwang, Hanna Trzeciakiewicz, Dave Friedmann, Chao-Xing Yuan, Ronen Marmorstein, Virginia M Y Lee, Todd J Cohen   +6 more
doaj   +1 more source

Skeletal muscle alpha actin acetylation enhances myosin binding and increases calcium sensitivity

Biophysical Reports
Skeletal muscle alpha actin (ACTA1) is important for muscle contraction and relaxation, with historical studies focused on ACTA1 mutations in muscle dysfunction.
Samantha S. Romanick, Luis Godoy, Adrian Lopez, Allison Matsumura, Kiana Boc, Travis J. Stewart, Josh E. Baker, Bradley S. Ferguson   +7 more
doaj   +1 more source

Acetylation of WRN protein regulates its stability by inhibiting ubiquitination. [PDF]

PLoS ONE, 2010
WRN is a multi-functional protein involving DNA replication, recombination and repair. WRN acetylation has been demonstrated playing an important role in response to DNA damage.
Kai Li, Rui Wang, Enerlyn Lozada, Wei Fan, David K Orren, Jianyuan Luo   +5 more
doaj   +1 more source

How important is the N-terminal acetylation of alpha-synuclein for its function and aggregation into amyloids?

Frontiers in Neuroscience, 2022
N-α-acetylation is a frequently occurring post-translational modification in eukaryotic proteins. It has manifold physiological consequences on the regulation and function of several proteins, with emerging studies suggesting that it is a global ...
Aditya Iyer, Arshdeep Sidhu, Vinod Subramaniam   +2 more
doaj   +1 more source

Progress of Acetylation Modification in Plants

Agronomy
Protein acetylation, a conserved post-translational modification, is collaboratively catalyzed by acetyltransferases and deacetylases and is widespread in plants.
Ruiqi Li, Xuezhong Li, Ying He, Xiaoyuan Chen, Jing Li, Chuxiong Zhuang   +5 more
doaj   +1 more source

Redox state and the sirtuin deacetylases are major factors that regulate the acetylation status of the stress protein NQO1

Frontiers in Pharmacology, 2022
The stress induced protein NQO1 can participate in a wide range of biological pathways which are dependent upon the interaction of NQO1 with protein targets.
David Siegel, Peter S. Harris, Cole R. Michel, Cole R. Michel, Rafael de Cabo, Kristofer S. Fritz, David Ross   +6 more
doaj   +1 more source

Influence of N^ε-Lysine Acetylation on the Formation of Protein Aggregates and Antibiotic Persistence in E. coli

Molecules
Numerous studies indicate that reversible Nε-lysine acetylation in bacteria may play a key role in the regulation of metabolic processes, transcription and translation, biofilm formation, virulence, and drug resistance.
Karolina Stojowska-Swędrzyńska, Dorota Kuczyńska-Wiśnik, Ewa Laskowska   +2 more
doaj   +1 more source

Post‐translational modifications of histones: Mechanisms, biological functions, and therapeutic targets

MedComm, 2023
Histones are DNA‐binding basic proteins found in chromosomes. After the histone translation, its amino tail undergoes various modifications, such as methylation, acetylation, phosphorylation, ubiquitination, malonylation, propionylation, butyrylation ...
Ruiqi Liu, Jiajun Wu, Haiwei Guo, Weiping Yao, Shuang Li, Yanwei Lu, Yongshi Jia, Xiaodong Liang, Jianming Tang, Haibo Zhang   +9 more
doaj   +1 more source

A Stoichiometric Solvent-Free Protocol for Acetylation Reactions

Frontiers in Chemistry, 2022
Considering the remarkable relevance of acetylated derivatives of phenols, alcohols, and aryl and alkyl thiols in different areas of biology, as well as in synthetic organic chemistry, a sustainable solvent-free approach to perform acetylation reactions ...
Francesca Valentini, Pierluca Galloni, Pierluca Galloni, Diana Brancadoro, Valeria Conte, Federica Sabuzi, Federica Sabuzi   +6 more
doaj   +1 more source