Results 11 to 20 of about 189,008 (259)
Integrative multi-omics analysis and machine learning refine global histone modification features in prostate cancer [PDF]
Frontiers in Molecular BiosciencesBackgroundProstate cancer (PCa) is a major cause of cancer-related mortality in men, characterized by significant heterogeneity in clinical behavior and treatment response.
XiaoFeng He +12 more
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Frontiers in Pharmacology, 2022 Dysregulated epigenetic enzymes and resultant abnormal epigenetic modifications (EMs) have been suggested to be closely related to tumor occurrence and progression.
Jianwei Feng, Xinyue Meng
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Noval advance of histone modification in inflammatory skin diseases and related treatment methods
Frontiers in ImmunologyInflammatory skin diseases are a group of diseases caused by the disruption of skin tissue due to immune system disorders. Histone modification plays a pivotal role in the pathogenesis and treatment of chronic inflammatory skin diseases, encompassing a ...
Lichen Zhang +13 more
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Aberrant histone modification in endometriosis
Frontiers in Bioscience - Landmark, 2014 Accumulating evidence suggests that epigenetic aberrations play definite roles in the pathogenesis of endometriosis. These include aberrations in genomic DNA methylation, microRNA expression, and histone modification. The aberrant histone modification status and the aberrant expression of histone deacetylases, which regulate histone acetylation, in ...
Kaei Nasu, Yoko Aoyagi, Kentaro Kai
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Algorithms, 2023 It is difficult to identify histone modification from datasets that contain high-throughput sequencing data. Although multiple methods have been developed to identify histone modification, most of these methods are not specific to histone modification ...
Turki Turki +2 more
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Histones and histone modifications [PDF]
Current Biology, 2004 Histone variants, distinct patterns of posttranslational modifications of histones, and histone tail binding proteins all contribute to establishment of various ‘open’ or ‘closed’ chromatin domains that have specialized folding properties and biological functions. Some of these domains can be propagated through DNA replication and mitosis, guaranteeing
Peterson, Craig L, Laniel, Marc-André
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Histone Modifications in Acute Kidney Injury
Kidney Diseases, 2022 Background: Acute kidney injury( AKI) is a serious clinical problem associated with high morbidity and mortality worldwide. The pathophysiology and pathogenesis of AKI is complex and multifactorial.
Jun Wang +3 more
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Frontiers in Physiology, 2023 Skeletal muscles, the largest organ responsible for energy metabolism in most mammals, play a vital role in maintaining the body’s homeostasis.
Junjie Xu, Chenglong Li, Xiaolong Kang
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The Regulation and Function of Histone Crotonylation
Frontiers in Cell and Developmental Biology, 2021 Histone crotonylation is a newly identified epigenetic modification that has a pronounced ability to regulate gene expression. It belongs to an expanding group of short chain lysine acylations that also includes the extensively studied mark histone ...
Angeliki Ntorla, Joseph Robert Burgoyne
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Readers of histone modifications [PDF]
Cell Research, 2011 Histone modifications not only play important roles in regulating chromatin structure and nuclear processes but also can be passed to daughter cells as epigenetic marks. Accumulating evidence suggests that the key function of histone modifications is to signal for recruitment or activity of downstream effectors. Here, we discuss the latest discovery of
Miyong, Yun +3 more
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