Results 1 to 10 of about 66,376 (233)
Frontiers in Genetics, 2022 Tight packaging of DNA in chromatin severely constrains DNA accessibility and dynamics. In contrast, nucleosomes in active chromatin state are highly flexible, can exchange their histones, and are virtually “transparent” to RNA polymerases, which ...
Wladyslaw A. Krajewski
doaj +1 more source
Diversity and Divergence of Dinoflagellate Histone Proteins
G3: Genes, Genomes, Genetics, 2016 Histone proteins and the nucleosomal organization of chromatin are near-universal eukaroytic features, with the exception of dinoflagellates. Previous studies have suggested that histones do not play a major role in the packaging of dinoflagellate ...
Georgi K. Marinov, Michael Lynch
doaj +1 more source
Stability of histone post-translational modifications in samples derived from liver tissue and primary hepatic cells. [PDF]
PLoS ONE, 2018 Chromatin structure, a key contributor to the regulation of gene expression, is modulated by a broad array of histone post-translational modifications (PTMs). Taken together, these "histone marks" comprise what is often referred to as the "histone code".
Philip A Gruppuso +10 more
doaj +1 more source
Toxins, 2022 Chromatin structure is a major regulator of DNA-associated processes, such as transcription, DNA repair, and replication. Histone post-translational modifications, or PTMs, play a key role on chromatin dynamics.
Aurelie Etier +3 more
doaj +1 more source
The Relevance of DNA Methylation and Histone Modification in Periodontitis: A Scoping Review
Cells, 2022 Background: Periodontitis is a chronic inflammatory disease involving an interplay between bacteria, inflammation, host response genes, and environmental factors.
Andrew Liaw +3 more
doaj +1 more source
Frontiers in Immunology, 2020 The number of diabetic patients in Europe and world-wide is growing. Diabetes confers a 2-fold higher risk for vascular disease. Lack of insulin production (Type 1 diabetes, T1D) or lack of insulin responsiveness (Type 2 diabetes, T2D) causes systemic ...
Dieuwertje M. Mossel +13 more
doaj +1 more source
An in vitro assay to study the recruitment and substrate specificity of chromatin modifying enzymes
Biological Procedures Online, 2004 Post-translational modifications of core histones play an important role in regulating fundamental biological processes such as DNA repair, transcription and replication.
Vermeulen Michiel +1 more
doaj +1 more source
Strategies To Modulate Heritable Epigenetic Defects in Cellular Machinery: Lessons from Nature
Pharmaceuticals, 2012 Natural epigenetic processes precisely orchestrate the intricate gene network by expressing and suppressing genes at the right place and time, thereby playing an essential role in maintaining the cellular homeostasis.
Ganesh N. Pandian, Hiroshi Sugiyama
doaj +1 more source
Localization of Epigenetic Markers in Leishmania Chromatin
Pathogens, 2022 Eukaryotes use histone variants and post-translation modifications (PTMs), as well as DNA base modifications, to regulate DNA replication/repair, chromosome condensation, and gene expression. Despite the unusual organization of their protein-coding genes
Jacquelyn R. McDonald +5 more
doaj +1 more source
The Histone Code of
mBio, 2013 Epigenetic gene regulation has emerged as a major mechanism for gene regulation in all eukaryotes. Histones are small, basic proteins that constitute the major protein component of chromatin, and posttranslational modifications (PTM) of histones are ...
Sheila C. Nardelli +10 more
doaj +1 more source