Results 21 to 30 of about 66,376 (233)
Plant Tolerance to Drought Stress with Emphasis on Wheat
Plants, 2023 Environmental stresses, such as drought, have negative effects on crop yield. Drought is a stress whose impact tends to increase in some critical regions. However, the worldwide population is continuously increasing and climate change may affect its food
Sarah Adel, Nicolas Carels
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Histone deacetylation: establishing a meiotic histone code. [PDF]
Cell Cycle, 2014 Histone posttranslational modifications are essential for the control of gene expression, chromatin structure, and genome integrity. Genome-wide histone modifications induce changes in large-scale chromatin structure leading to the formation of distinct chromosomal domains that are heritable through mitosis and essential for cell division. Transmission
De La Fuente R.
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Translating the Histone Code [PDF]
Science, 2001 Chromatin, the physiological template of all eukaryotic genetic information, is subject to a diverse array of posttranslational modifications that largely impinge on histone amino termini, thereby regulating access to the underlying DNA. Distinct histone amino-terminal modifications can generate synergistic or antagonistic interaction affinities for ...
T, Jenuwein, C D, Allis
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Current Opinion in Chemical Biology, 2015 Chromatin is the universal template of genetic information in all eukaryotic cells. This complex of DNA and histone proteins not only packages and organizes genomes but also regulates gene expression. A multitude of posttranslational histone modifications and their combinations are thought to constitute a code for directing distinct structural and ...
Fischle, W., Mootz, H., Schwarzer, D.
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Neurogenetic and Neuroepigenetic Mechanisms in Cognitive Health and Disease
Frontiers in Molecular Neuroscience, 2020 Over the last two decades, the explosion of experimental, computational, and high-throughput technologies has led to critical insights into how the brain functions in health and disease.
Davide Martino Coda, Johannes Gräff
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Identification of lysine 37 of histone H2B as a novel site of methylation. [PDF]
PLoS ONE, 2011 Recent technological advancements have allowed for highly-sophisticated mass spectrometry-based studies of the histone code, which predicts that combinations of post-translational modifications (PTMs) on histone proteins result in defined biological ...
Kathryn E Gardner +4 more
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Translating the histone code into leukemia [PDF]
Journal of Cellular Biochemistry, 2005 AbstractThe “histone code” is comprised of the covalent modifications of histone tails that function to regulate gene transcription. The post‐translational modifications that occur in histones within the regulatory regions of genes include acetylation, methylation, phosphorylation, ubiquitination, sumoylation, and ADP‐ribosylation.
Bryan E, Linggi +3 more
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Writing the histone code [PDF]
Nature Methods, 2012 Recruiting chromatin modifiers to a specific locus allows the regulation of heterochromatin formation in living cells.
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Reprogramming the Histone Code
Chemistry & Biology, 2007 Histone lysine methyltransferases, like G9a, play central roles in the regulation of gene expression. A current study by Kubicek et al. [1] reports the identification of a G9a small-molecule inhibitor, thereby opening the way to new epigenetic cancer therapies.
Shaaban, Salam A., Bedford, Mark T.
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Visualizing the Histone Code on LSD1 [PDF]
Cell, 2007 In this issue, Garcia-Bassets et al. (2007) show that spurious transcriptional activation by unliganded nuclear receptors is inhibited by histone lysine methylation. This inhibitory histone modification code is efficiently countered by the ligand-dependent recruitment of histone lysine demethylases, including lysine-specific demethylase 1 (LSD1), which
Gamble, Matthew J., Kraus, W. Lee
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