Results 11 to 20 of about 66,376 (233)
The Histone Code of Senescence [PDF]
Cells, 2020 Senescence is the end point of a complex cellular response that proceeds through a set of highly regulated steps. Initially, the permanent cell-cycle arrest that characterizes senescence is a pro-survival response to irreparable DNA damage.
Harikrishnareddy Paluvai +2 more
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Is There a Histone Code for Cellular Quiescence? [PDF]
Frontiers in Cell and Developmental Biology, 2021 Many of the cells in our bodies are quiescent, that is, temporarily not dividing. Under certain physiological conditions such as during tissue repair and maintenance, quiescent cells receive the appropriate stimulus and are induced to enter the cell ...
Kenya Bonitto +9 more
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Unraveling the complexity of the histone code: implications for gene regulation and disease [PDF]
Genome BiologyHistone post-translational modifications epigenetically regulate gene expression by modulating nucleosome structure and DNA accessibility. This review outlines how unique patterns of modifications on canonical and variant histones generate a ...
Kiera L. Malone +13 more
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Nucleosome conformation dictates the histone code [PDF]
eLifeHistone post-translational modifications (PTMs) play a critical role in chromatin regulation. It has been proposed that these PTMs form localized ‘codes’ that are read by specialized regions (reader domains) in chromatin-associated proteins (CAPs) to ...
Matthew R Marunde +22 more
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Machine learning uncovers cell identity regulator by histone code [PDF]
Nature Communications, 2020 Identification of genes that determine and regulate cell identity remains challenging. Here, the authors use machine learning to identify cell identity genes and master regulator transcription factors based on gene expression profiles and histone ...
Bo Xia +12 more
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Histone clipping: the punctuation in the histone code. [PDF]
EMBO Rep, 2021 Histone clipping was first discovered in the 1960s and still is a lingering mystery. Considering the essential roles of histones in regulating eukaryotic transcription through the histone code, clipping is a post-translational modification that appeals to the imagination.
Dhaenens M.
europepmc +4 more sources
Site-specific programming characterizes dynamic post-translational acetylation of histone H2B lysine 108 in mouse embryonic stem cells [PDF]
Nature CommunicationsDynamic histone modifications are critical for regulating stem cell fate. However, generalized strategies for site-specific programming of histone modifications profiling on unperturbed chromatin in embryonic stem cells (ESCs) remain challenging. In this
Fangni Chai +7 more
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Oncohistones: Hijacking the histone code. [PDF]
Annu Rev Cancer Biol, 2022 Chromatin dysfunction has been implicated in a growing number of cancers especially in children and young adults. In addition to chromatin-modifying and -remodeling enzymes, mutations in histone genes are linked to human cancers. Since the first reports of hotspot missense mutations affecting key residues at the histone H3 tail, studies have revealed ...
Sahu V, Lu C.
europepmc +3 more sources
On the Hunt for the Histone Code. [PDF]
Mol Cell ProteomicsOur genome is not made of naked DNA but a fiber (chromatin) composed of DNA and proteins packaged into our chromosomes. The basic building block of chromatin is the nucleosome, which has two copies of each of the proteins called histones (H2A, H2B, H3, and H4) wrapped by 146 base pairs of DNA.
Ueberheide BM, Mollah S, Garcia BA.
europepmc +3 more sources
Histone Sample Preparation for Bottom-Up Mass Spectrometry: A Roadmap to Informed Decisions
Proteomes, 2021 Histone-based chromatin organization enabled eukaryotic genome complexity. This epigenetic control mechanism allowed for the differentiation of stable gene-expression and thus the very existence of multicellular organisms.
Simon Daled +7 more
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