Results 1 to 10 of about 89,797 (267)
Clinical application of liquid biopsy in cancer patients
BMC Cancer, 2022 Background This study was to determine the prevalence and clinical significance of clonal hematopoiesis (CH)-related variants, and somatic and germline mutations in cancer patients and healthy individuals.
Chieh-Min Chang +7 more
doaj +1 more source
Therapeutic and immunomodulatory potential of pazopanib in malignant phyllodes tumor
npj Breast Cancer, 2022 Malignant phyllodes tumors (PT) are rare aggressive fibroepithelial neoplasms with high metastatic potential and lack effective therapy. We established a patient-derived xenograft (PDX) and cell line model (designated MPT-S1) of malignant PT which ...
Dave Yong Xiang Ng +20 more
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Cell-Free miR-27a, a Potential Diagnostic and Prognostic Biomarker for Gastric Cancer [PDF]
Genomics & Informatics, 2015 MicroRNAs (miRNAs) have been demonstrated to play an important role in carcinogenesis. Previous studies revealed that miRNAs are present in human plasma in a remarkably stable form that is protected from endogenous RNase activity.
Jong-Lyul Park +4 more
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Concurrent mapping of multiple epigenetic marks and co-occupancy using ACT2-seq
Cell & Bioscience, 2021 Background Genome-wide profiling of epigenetic marks is a core technology in molecular genetics. Co-occupancy of different epigenetic marks or protein factors at the same genomic locations must often be inferred from multiple independently collected data
Benjamin Carter +3 more
doaj +1 more source
Infection of Brain Organoids and 2D Cortical Neurons with SARS-CoV-2 Pseudovirus
Viruses, 2020 Since the global outbreak of SARS-CoV-2 (COVID-19), infections of diverse human organs along with multiple symptoms continue to be reported. However, the susceptibility of the brain to SARS-CoV-2, and the mechanisms underlying neurological infection are ...
Sang Ah Yi +8 more
doaj +1 more source
Mutation profile of non-small cell lung cancer revealed by next generation sequencing
Respiratory Research, 2021 Background Precision therapy for lung cancer requires comprehensive genomic analyses. Specific effects of targeted therapies have been reported in Asia populations, including Taiwanese, but genomic studies have rarely been performed in these populations.
Ya-Sian Chang +7 more
doaj +1 more source
Epigenetic Biomarkers for Environmental Exposures and Personalized Breast Cancer Prevention. [PDF]
, 2020 Environmental and lifestyle factors are believed to account for >80% of breast cancers; however, it is not well understood how and when these factors affect risk and which exposed individuals will actually develop the disease.
Park, Hannah Lui
core +1 more source
Nature Communications, 2020 An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Benjamin Carter +6 more
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Arthritis Research & Therapy, 2022 Background Gout is a highly hereditary disease, but not all those carrying well-known risk variants have developing gout attack even in hyperuricemia status.
Ya-Sian Chang +8 more
doaj +1 more source
Molecular Genetics & Genomic Medicine, 2022 Background Autosomal dominant polycystic kidney disease (ADPKD) is an inherited cystic kidney disease associated with a spectrum of various renal and extrarenal manifestations, including increased risk of kidney cancers.
Elizabeth Lee +12 more
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