Results 21 to 30 of about 63,478 (191)
The Epigenomics of Cancer [PDF]
Cell, 2007 Aberrant gene function and altered patterns of gene expression are key features of cancer. Growing evidence shows that acquired epigenetic abnormalities participate with genetic alterations to cause this dysregulation. Here, we review recent advances in understanding how epigenetic alterations participate in the earliest stages of neoplasia, including ...
Jones, Peter A., Baylin, Stephen B.
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melRNA-seq for Expression Analysis of SINE RNAs and Other Medium-Length Non-Coding RNAs
Mobile DNA, 2021 Background Small interspersed elements (SINEs) are transcribed by RNA polymerase III (Pol III) to produce RNAs typically 100–500 nucleotides in length.
Yoshinobu Mori, Kenji Ichiyanagi
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Cell, 2012 The eukaryotic genome is packaged into a highly ordered chromatin structure, with specific domains regulating the transcription patterns of local genes. Hathaway et al. now present a breakthrough technique in the artificial induction of chromatin marks and use this experimental model to test the properties of an induced heterochromatic domain.
Carone, Benjamin R., Rando, Oliver J.
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GEroNIMO : Genome and Epigenome eNabled breedIng in MOnogastrics
, 2023 International audienceSustainable animal breeding should ensure efficient resource use and animal health and welfare, while preserving genetic diversity.
Pitel, Frédérique +2 more
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Nature Communications, 2019 The authors introduce ACT-seq: a Tn5-based method for rapidly profiling epigenetic marks in bulk-cell and single-cell samples. ACT-seq avoids many laborious or time-consuming steps required for similar techniques including chromatin fragmentation and end
Benjamin Carter +6 more
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Epigenetic Memories in Hematopoietic Stem and Progenitor Cells
Cells, 2022 The recent development of next-generation sequencing (NGS) technologies has contributed to research into various biological processes. These novel NGS technologies have revealed the involvement of epigenetic memories in trained immunity, which are ...
Kazumasa Aoyama +3 more
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Nature Reviews Microbiology, 2019 In all domains of life, genomes contain epigenetic information superimposed over the nucleotide sequence. Epigenetic signals control DNA-protein interactions and can cause phenotypic change in the absence of mutation. A nearly universal mechanism of epigenetic signalling is DNA methylation.
María A. Sánchez-Romero +1 more
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Current Opinion in Nephrology and Hypertension, 2020 Epigenetic modifications are reversible changes to a cell's DNA or histones that alter gene expression but not DNA sequence. The present review will explore epigenomic profiling and bioinformatics techniques for the study of kidney development and disease.Reversible DNA and histone modifications influence chromatin accessibility and can be measured by ...
Parker C, Wilson +2 more
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Epigenetic alterations in TRAMP mice: epigenome DNA methylation profiling using MeDIP-seq
Cell & Bioscience, 2018 Purpose We investigated the genomic DNA methylation profile of prostate cancer in transgenic adenocarcinoma of the mouse prostate (TRAMP) cancer model and to analyze the crosstalk among targeted genes and the related functional pathways. Methods Prostate
Wenji Li +11 more
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Nature Reviews Immunology, 2021 A new study in Cell provides a single-cell map of the epigenetic and transcriptomic landscape in response to influenza vaccination, revealing persistent epigenomic remodelling in myeloid cells and the antiviral effects of adjuvant.
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