Results 11 to 20 of about 63,478 (191)
Frontiers in Oncology, 2013 It is well known that Neuroblastoma (NB) patients whose tumors have an undifferentiated histology and a transcriptome enriched in cell cycle genes have a worse prognosis.
Stanley eHe +3 more
doaj +3 more sources
Genomic Medicine, 2008 'Epigenomics' can be termed as the study of the effects of chromatin structure, including the higher order of chromatin folding and attachment to the nuclear matrix, packaging of DNA around nucleosomes, covalent modifications of histone tails and DNA methylation. This has evolved to include any process that alters gene activity without changing the DNA
Virendra S, Gomase, Somnath, Tagore
+7 more sources
Neuroblastoma and the epigenome [PDF]
Cancer and Metastasis Reviews, 2021 AbstractNeuroblastoma (NB) is a pediatric cancer of the sympathetic nervous system and one of the most common solid tumors in infancy. Amplification of MYCN, copy number alterations, numerical and segmental chromosomal aberrations, mutations, and rearrangements on a handful of genes, such as ALK, ATRX, TP53, RAS/MAPK pathway genes, and TERT, are ...
Irfete S. Fetahu, Sabine Taschner-Mandl
openaire +2 more sources
The Decade of the Epigenomes? [PDF]
Genes & Cancer, 2011 The beginning of this century was not only marked by the publication of the first draft of the human genome but also set off a decade of intense research on epigenetic phenomena. Apart from DNA methylation, it became clear that many other factors including a wide range of histone modifications, different shades of chromatin accessibility, and a vast ...
Martens, J.H.A. +2 more
openaire +4 more sources
Regenerating the epigenome [PDF]
The EMBO Reports, 2011 The ability of some organisms to regenerate parts of their body has fascinated scientists for decades. The process of regeneration depends on the potential of certain cells to proliferate and contribute to the formation of new tissue. Organisms have evolved two strategies by which to achieve this: the maintenance of adult stem cells and the induction ...
Maria J, Barrero +1 more
openaire +2 more sources
Epigenome editing in animal production: a prospective review
Epigenome editing is a set of molecular approaches that aims at modifying one or several epigenetics marks in one or a few target genomic regions. It can be used to decipher the causal regulatory mechanisms governing gene expression, to validate putative
Pértille, Fábio +4 more
core +6 more sources
Epigenomics of macrophages [PDF]
Immunological Reviews, 2014 SummaryMacrophages play essential roles in tissue homeostasis, pathogen elimination, and tissue repair. A defining characteristic of these cells is their ability to efficiently adapt to a variety of abruptly changing and complex environments. This ability is intrinsically linked to a capacity to quickly alter their transcriptome, and this is tightly ...
David, Gosselin, Christopher K, Glass
openaire +2 more sources
Genomics and epigenomics [PDF]
The Journal of Headache and Pain, 2015 Migraine with (MA) and without aura (MO) is a common brain disorder that affects 15% of the general population. Genetic studies on twins have shown that MA and MO heritability spans between 50% and 60%[1]. Despite the high degree of heritability the genetic basis of MA and MO has not been elucidated and on the whole their etiology is far from being ...
Garagnani P. +8 more
openaire +2 more sources
scPCOR-seq enables co-profiling of chromatin occupancy and RNAs in single cells
Communications Biology, 2022 scPCOR-seq is a single-cell sequencing technique that enables simultaneous profiling of genome-wide chromatin protein binding or histone modification marks and RNA expression in the same cell.
Lixia Pan +4 more
doaj +1 more source
Nature Communications, 2018 Over the past decade, remarkable breakthroughs in our understanding of epigenetic biology have coincided with an increased public interest in the impact of diet and lifestyle choices on health. It is well established that a balanced diet enhances life expectancy and helps to prevent or treat certain diseases, such as obesity, diabetes, cancer, and ...
Yi Zhang, Tatiana G. Kutateladze
openaire +3 more sources