Results 11 to 20 of about 89,797 (267)
Genomic Medicine, 2008 'Epigenomics' can be termed as the study of the effects of chromatin structure, including the higher order of chromatin folding and attachment to the nuclear matrix, packaging of DNA around nucleosomes, covalent modifications of histone tails and DNA methylation. This has evolved to include any process that alters gene activity without changing the DNA
Virendra S, Gomase, Somnath, Tagore
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Environmental Epigenomes [PDF]
Epigenomes, 2023 Research in epigenetics has dramatically risen during the last decade to include aspects of environmental biology. However, many questions remain regarding the effects of environmental stressors on the epigenome, incorporating the particular role of epigenetic mechanisms in the adaptation and evolution of organisms in changing environments. Epigenetics
Bambarendage P. U. Perera +1 more
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Circulation Research, 2018 The advent of high-throughput epigenome mapping technologies has ushered in a new era of multiomics where powerful tools can now delineate and record different layers of genomic output. Integrating various components of the epigenome from these multiomics measurements allows the interrogation of cellular heterogeneity in addition to the discovery of ...
Kevin C, Wang, Howard Y, Chang
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Nature Reviews Immunology, 2021 A new study in Cell provides a single-cell map of the epigenetic and transcriptomic landscape in response to influenza vaccination, revealing persistent epigenomic remodelling in myeloid cells and the antiviral effects of adjuvant.
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Hi-TrAC reveals division of labor of transcription factors in organizing chromatin loops
Nature Communications, 2022 The three-dimensional genomic structure plays a critical role in gene expression, cellular differentiation, and pathological conditions. It is pivotal to elucidate fine-scale chromatin architectures, especially interactions of regulatory elements, to ...
Shuai Liu +4 more
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scPCOR-seq enables co-profiling of chromatin occupancy and RNAs in single cells
Communications Biology, 2022 scPCOR-seq is a single-cell sequencing technique that enables simultaneous profiling of genome-wide chromatin protein binding or histone modification marks and RNA expression in the same cell.
Lixia Pan +4 more
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Exercise epigenetics and the foetal origins of disease [PDF]
, 2014 Exercise epigenetics is a nascent area of research with vast health implications (e.g., from the treatment of obesity-related diseases to beneficially decoupling epigenetic and chronological age).
Dale E, Thomas EW Chalk, William M Brown
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The epigenetic clock is correlated with physical and cognitive fitness in the Lothian Birth Cohort 1936 [PDF]
, 2015 Background: The DNA methylation-based 'epigenetic clock' correlates strongly with chronological age, but it is currently unclear what drives individual differences. We examine cross-sectional and longitudinal associations between the epigenetic clock and
Corley, Janie +17 more
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Epigenetic Memories in Hematopoietic Stem and Progenitor Cells
Cells, 2022 The recent development of next-generation sequencing (NGS) technologies has contributed to research into various biological processes. These novel NGS technologies have revealed the involvement of epigenetic memories in trained immunity, which are ...
Kazumasa Aoyama +3 more
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The importance of detailed epigenomic profiling of different cell types within organs. [PDF]
, 2016 The human body consists of hundreds of kinds of cells specified from a single genome overlaid with cell type-specific epigenetic information. Comprehensively profiling the body's distinct epigenetic landscapes will allow researchers to verify cell types ...
Borok, Zea +4 more
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