Results 31 to 40 of about 63,478 (191)
Microorganisms, 2021 DNA methylation is a common, but not universal, epigenetic modification that plays an important role in multiple cellular processes. While definitely settled for numerous plant, mammalian, and bacterial species, the genome methylation in different fungal
Monika Kubiak-Szymendera +3 more
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Mobile DNA, 2017 Background Intracisternal A particle (IAP) is one of the most transpositionally active retrotransposons in the mouse genome, but its expression varies between cell types. This variation is believed to arise from differences in the epigenetic state (e.g.,
Ken-ichi Shimosuga +3 more
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Epigenomics of Hypertension [PDF]
Seminars in Nephrology, 2013 Multiple genes and pathways are involved in the pathogenesis of hypertension. Epigenomic studies of hypertension are beginning to emerge and hold great promise of providing novel insights into the mechanisms underlying hypertension. Epigenetic marks or mediators including DNA methylation, histone modifications, and noncoding RNA can be studied at a ...
Mingyu, Liang +4 more
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The allure of the epigenome [PDF]
Genome Biology, 2012 The Oxford English Dictionary dates the word 'genome' to 1926 but has not yet seen fit to include the term 'epigenome' in its illustrious pages (where it would reside handsomely between 'epigenist' and 'epigenous'). This differential treatment reflects a state of affairs in which the epigenome has yet to infiltrate the popular imagination, but belies ...
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Epigenomes, 2023 Research in epigenetics has dramatically risen during the last decade to include aspects of environmental biology. However, many questions remain regarding the effects of environmental stressors on the epigenome, incorporating the particular role of epigenetic mechanisms in the adaptation and evolution of organisms in changing environments. Epigenetics
Bambarendage P. U. Perera +1 more
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DNA methylation profiles unique to Kalahari KhoeSan individuals
Epigenetics, 2021 Genomes of KhoeSan individuals of the Kalahari Desert provide the greatest understanding of single nucleotide diversity in the human genome. Compared with individuals in industrialized environments, the KhoeSan have a unique foraging and hunting ...
Alexander Goncearenco +7 more
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The International Human Epigenome Consortium: A Blueprint for Scientific Collaboration and Discovery [PDF]
The International Human Epigenome Consortium (IHEC) coordinates the generation of a catalog of high-resolution reference epigenomes of major primary human cell types.
Stunnenberg HG +2 more
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Epigenome-based cancer risk prediction: rationale, opportunities and challenges
, 2018 The incidence of cancer is continuing to rise and risk-tailored early diagnostic and/or primary prevention strategies are urgently required. The ideal risk-predictive test should: integrate the effects of both genetic and nongenetic factors and aim to ...
U. Siebert (6534434) +25 more
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Cell, 2007 Chemical modifications to DNA and histone proteins form a complex regulatory network that modulates chromatin structure and genome function. The epigenome refers to the complete description of these potentially heritable changes across the genome. The composition of the epigenome within a given cell is a function of genetic determinants, lineage, and ...
Bernstein, Bradley E. +2 more
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Epigenome-wide association results of maternal age in NFCS newborns.
, 2016 Volcano plot showing the relationship between the effect magnitude (coefficient) and strength of association (p-value) for Model1. The red horizontal line denotes the strict threshold for epigenome-wide significance based on a conservative Bonferroni ...
Zongli Xu (36200) +12 more
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