Results 41 to 50 of about 63,478 (191)
Nature Reviews Cancer, 2020 Epigenetic regulation is critical to physiological control of development, cell fate, cell proliferation, genomic integrity, and fundamentally, transcriptional regulation. This epigenetic control occurs at multiple levels including through DNA methylation, histone modification, nucleosome remodeling, and modulation of the three-dimensional chromatin ...
Benjamin A. Nacev +7 more
openaire +3 more sources
Reduced NCOR2 expression accelerates androgen deprivation therapy failure in prostate cancer
Cell Reports, 2021 Summary: This study addresses the roles of nuclear receptor corepressor 2 (NCOR2) in prostate cancer (PC) progression in response to androgen deprivation therapy (ADT).
Mark D. Long +14 more
doaj +1 more source
Epigenome-wide association study of motor impairment in preterm and low birth weight infants
, 2021 This thesis is an Epigenome Wide association study on motor impairment in preterm and low birth weight infants. Five differentially methylated probes and 35 differentially methylated regions that are potentially linked to general motor impairment were ...
Jennifer Snowball (19985694)
core
The Epigenome in Atherosclerosis [PDF]
, 2020 AbstractEmerging evidence suggests the growing importance of “nongenetic factors” in the pathogenesis of atherosclerotic vascular disease. Indeed, the inherited genome determines only part of the risk profile as genomic approaches do not take into account additional layers of biological regulation by “epi”-genetic changes.
Sarah, Costantino, Francesco, Paneni
openaire +2 more sources
Restructuring of Lamina-Associated Domains in Senescence and Cancer
Cells, 2022 Induction of cellular senescence or cancer is associated with a reshaping of the nuclear envelope and a broad reorganization of heterochromatin. At the periphery of mammalian nuclei, heterochromatin is stabilized at the nuclear lamina via lamina ...
Aurélie Bellanger +3 more
doaj +1 more source
Molecular Cell, 2016 During aging, the mechanisms that normally maintain health and stress resistance strikingly decline, resulting in decrepitude, frailty, and ultimately death. Exactly when and how this decline occurs is unknown. Changes in transcriptional networks and chromatin state lie at the heart of age-dependent decline.
Lauren N, Booth, Anne, Brunet
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Cell Reports, 2021 Summary: Human induced pluripotent stem cells (hiPSCs) show variable differentiation potential due to their epigenomic heterogeneity, whose extent/attributes remain unclear, except for well-studied elements/chromosomes such as imprints and the X ...
Shihori Yokobayashi +10 more
doaj +1 more source
aakashbasu2/Deciphering-the-mechanical-code-of-the-genome-and-epigenome: First Release
, 2022 First release of codes associated with the publication "Deciphering the mechanical code of the genome and ...
aakashbasu2
core +1 more source
CTCF and cellular heterogeneity
Cell & Bioscience, 2019 Cellular heterogeneity, which was initially defined for tumor cells, is a fundamental property of all cellular systems, ranging from genetic diversity to cell-to-cell variation driven by stochastic molecular interactions involved all cellular processes ...
Gang Ren, Keji Zhao
doaj +1 more source
The Toolbox for Untangling Chromosome Architecture in Immune Cells
Frontiers in Immunology, 2021 The code of life is not only encrypted in the sequence of DNA but also in the way it is organized into chromosomes. Chromosome architecture is gradually being recognized as an important player in regulating cell activities (e.g., controlling ...
Shuai Liu, Keji Zhao
doaj +1 more source