Results 61 to 70 of about 89,797 (267)
Maternal obesity blunts antimicrobial responses in fetal monocytes
eLife, 2023 Maternal pre-pregnancy (pregravid) obesity is associated with adverse outcomes for both mother and offspring. Amongst the complications for the offspring is increased susceptibility and severity of neonatal infections necessitating admission to the ...
Suhas Sureshchandra +6 more
doaj +1 more source
Advanced Science, EarlyView.Ng et al. show that the BCR::ABL1 kinase that drives the lymphoid leukemia Ph+B‐ALL modulates enhancer function by coopting signaling‐inducible transcription factors such as MYC, STAT5, and ETV5. BCR::ABL1 thereby promotes the transcriptional program driving and defining this leukemia and renders Ph+B‐ALL cells hypersensitive to enhancer‐inhibiting ...
Han Leng Ng +19 more
wiley +1 more source
DNA Hydroxymethylation at the Interface of the Environment and Nonalcoholic Fatty Liver Disease. [PDF]
, 2019 Non-alcoholic fatty liver disease (NAFLD) is one of the most prevalent forms of chronic liver disorders among adults, children, and adolescents, and a growing epidemic, worldwide.
Besaratinia, Ahmad, Tommasi, Stella
core +1 more source
Epigenomics-Based Diagnostics [PDF]
Clinical Chemistry, 2010 The term “epigenetics,” first coined in 1942, refers to heritable traits of cells (over many rounds of cell division) that do not involve changes to the underlying DNA sequence. The 2 predominant epigenetic mechanisms are DNA methylation and histone modification.
Eleftherios P, Diamandis +4 more
openaire +2 more sources
Advanced Science, EarlyView.Prolonged exposure to stiff extracellular matrix drives cancer‐associated fibroblasts into a persistently activated myofibroblast state. Two parallel pathways are identified: β1 integrin activation smoothens the nuclear lamina to reduce lamin–chromatin contacts, while the formin mDia2 regulates nuclear actin to alter chromatin organization.
Swathi Packirisamy +4 more
wiley +1 more source
Nature CommunicationsDNA damage compromises not only genome stability but also chromatin integrity, which plays a central role in controlling cell identity. Chromatin repair entails the deposition of new histones at sites of DNA damage.
Alexandre Plessier +5 more
doaj +1 more source
Maternal Mineral Nutrition Regulates Fetal Genomic Programming in Cattle: A Review
Metabolites, 2023 Maternal mineral nutrition during the critical phases of fetal development may leave lifetime impacts on the productivity of an individual. Most research within the developmental origins of the health and disease (DOHaD) field is focused on the role of ...
Muhammad Anas +6 more
doaj +1 more source
T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities
Advanced Science, EarlyView.T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu +7 more
wiley +1 more source
Cancer Medicine, 2019 Next‐generation sequencing (NGS) technology is currently used to establish mutational profiles in many heterogeneous diseases. The aim of this study was to evaluate the mutational spectrum in Taiwanese patients with colorectal cancer (CRC) to help ...
Ya‐Sian Chang +6 more
doaj +1 more source
Epigenomes in Cardiovascular Disease. [PDF]
, 2018 If unifying principles could be revealed for how the same genome encodes different eukaryotic cells and for how genetic variability and environmental input are integrated to impact cardiovascular health, grand challenges in basic cell biology and ...
McKinsey TA +4 more
core +1 more source