Results 81 to 90 of about 89,797 (267)

MYCN and the Epigenome

Frontiers in Oncology, 2013
It is well known that Neuroblastoma (NB) patients whose tumors have an undifferentiated histology and a transcriptome enriched in cell cycle genes have a worse prognosis.
Stanley eHe, Zhihui eLiu, Doo-Yi eOh, Carol J Thiele   +3 more
doaj   +1 more source

The 3D Genome Browser: A web-based browser for visualizing 3D genome organization and long-range chromatin interactions [PDF]

, 2018
Here, we introduce the 3D Genome Browser, http://3dgenome.org, which allows users to conveniently explore both their own and over 300 publicly available chromatin interaction data of different types.
Choudhary, Mayank N.K., Hardison, Ross, Hu, Ming, Kuang, Da, Li, Daofeng, Li, Yun, Song, Fan, Wang, Ting, Wang, Yanli, Xu, Jie, Yue, Feng, Zhang, Bo, Zhang, Lijun   +12 more
core   +2 more sources

Plant Genetic Engineering: Technological Pathways, Application Scenarios, and Future Directions

Advanced Science, EarlyView.
This review maps the fast‐evolving landscape of plant genetic engineering, linking enabling platforms with trait‐focused applications in architecture optimization, stress resilience, yield improvement, and quality enhancement. It highlights how genome editing, transgenic strategies, and emerging multi‐gene approaches reshape breeding pipelines, while ...
Peilin Wang, Wenzhi Wang, Dongjiao Wang, Qibin Wu, Youxiong Que   +4 more
wiley   +1 more source

Beyond the Exome: The Non-coding Genome and Enhancers in Neurodevelopmental Disorders and Malformations of Cortical Development

Frontiers in Cellular Neuroscience, 2019
The development of the human cerebral cortex is a complex and dynamic process, in which neural stem cell proliferation, neuronal migration, and post-migratory neuronal organization need to occur in a well-organized fashion.
Elena Perenthaler, Soheil Yousefi, Eva Niggl, Tahsin Stefan Barakat   +3 more
doaj   +1 more source

The Age‐Dependent Resident Myonuclear Multi‐Omic Response to an Acute Skeletal Muscle Hypertrophic Stimulus in Mice

Advanced Science, EarlyView.
Resident myonuclei are the molecular “control centers” for large multinuclear muscle fibers. It is presumed that, with aging, these control centers become compromised and contribute to delayed or blunted muscle adaptive potential. This study is a detailed roadmap that exposes how young versus aged myonuclei respond to a hypertrophic loading stimulus ...
Pieter J. Koopmans, Ronald G. Jones III, Ana Regina Cabrera, Francielly Morena, Nicholas P. Greene, John J. McCarthy, Ahmed Ismaeel, Yuan Wen, Kevin A. Murach   +8 more
wiley   +1 more source

The Aging Epigenome [PDF]

Molecular Cell, 2016
During aging, the mechanisms that normally maintain health and stress resistance strikingly decline, resulting in decrepitude, frailty, and ultimately death. Exactly when and how this decline occurs is unknown. Changes in transcriptional networks and chromatin state lie at the heart of age-dependent decline.
Lauren N, Booth, Anne, Brunet
openaire   +2 more sources

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Predicting cell types and genetic variations contributing to disease by combining GWAS and epigenetic data [PDF]

, 2013
Genome-wide association studies (GWASs) identify single nucleotide polymorphisms (SNPs) that are enriched in individuals suffering from a given disease. Most disease-associated SNPs fall into non-coding regions, so that it is not straightforward to infer
A Milosavljevic, A Pekowska, A Visel, AJ Saldanha, AM Mondul, Anjana Rao, Anna Gerasimova, AR Quinlan, BE Bernstein, BE Himes, BE Stranger, Bin Li, Bjoern Peters, C Ober, C Zang, Consortium The International HapMap, D Karolchik, DB Hancock, DG Torgerson, E Birney, E Noguchi, EK Miller, F Castro-Giner, G Hon, GE Zentner, Gregory Seumois, J Ernst, J Ernst, J Harrow, Jason Greenbaum, JH Kim, JJ Farrell, KM Ansel, LD Ward, Lukas Chavez, MA Schaub, MF Moffatt, MF Moffatt, MJ de Hoon, MP Creyghton, MT Maurano, ND Heintzman, NU Rashid, Pandurangan Vijayanand, PB Talbert, PM Sleiman, PM Visscher, R Bhandare, R Jaenisch, S Chanock, S Michel, S Weidinger, T Hirota, TH Pham, W Yu, Y Li, Y Zhang, Yi-Hsiang Hsu   +57 more
core   +3 more sources

Cross‐Modal Denoising and Integration of Spatial Multi‐Omics Data with CANDIES

Advanced Science, EarlyView.
In this paper, we introduce CANDIES, which leverages a conditional diffusion model and contrastive learning to effectively denoise and integrate spatial multi‐omics data. We conduct extensive evaluations on diverse synthetic and real datasets, CANDIES shows superior performance on various downstream tasks, including denoising, spatial domain ...
Ye Liu, Wanpeng Zou, Yuekai Li, Jiayi Wang, Mingxuan Cai, Hongmin Cai   +5 more
wiley   +1 more source

Multi‐Omics Insights Into the Mechanisms of Early Muscle Fiber Difference and Transformation Between Lean‐Type and Chinese Indigenous Pigs

Advanced Science, EarlyView.
Multi‐omics analyses uncover breed‐specific cis‐regulatory landscapes and higher‐order chromatin architectural differences that underlie early postnatal muscle fiber divergence in pigs. A super‐enhancer upstream of PPP3CB recruits MEF2C to activate PPP3CB transcription, while the PPP3CB–MEF2C positive feedback loop promotes oxidative muscle fiber ...
Shuailong Zheng, Hainan Wu, Min Liu, Kunpeng Wu, Shuntao Huang, Zulfiqar Ahmed, Lenox Pius, Mengjin Zhu, Dequan Xu   +8 more
wiley   +1 more source