Results 81 to 90 of about 63,478 (191)

Elucidation of chromatin loops among regulatory regions using Hi-TrAC

Frontiers in Epigenetics and Epigenomics
Cellular development and differentiation are critically regulated by the spatiotemporal expression of genes within the genome, which are packaged into a highly organized chromatin structure.
Yaqiang Cao, Qingsong Tang, Keji Zhao
doaj   +1 more source

Insertion of short L1 sequences generates inter-strain histone acetylation differences in the mouse

Mobile DNA
Background Gene expression divergence between populations and between individuals can emerge from genetic variations within the genes and/or in the cis regulatory elements.
Beverly Ann G. Boyboy, Kenji Ichiyanagi
doaj   +1 more source

Human Alu loci gain enhancer-type epigenetic modifications in monocytes during response to bacterial LPS

Epigenetics & Chromatin
Background Bacterial lipopolysaccharide (LPS) potently activates innate immunity. Transposable elements (TEs), particularly lineage-specific short interspersed elements (SINEs), have been implicated in immune regulatory evolution, yet their epigenomic ...
Yonghao Pan, Kenji Ichiyanagi
doaj   +1 more source

Transcription factor network dynamics during the commitment to oncogene-induced senescence

Frontiers in Epigenetics and Epigenomics
Aberrant oncogenic signaling causes cells to transition into oncogene-induced senescence (OIS) to limit uncontrolled proliferation. Despite being a potent tumor suppressor mechanism, OIS is an unstable cell state susceptible to reprogramming that can ...
Themistoklis Vasilopoulos, Ricardo Iván Martínez-Zamudio   +1 more
doaj   +1 more source

Epigenome-wide association study of thyroid function traits identifies novel associations of fT3 with KLF9 and DOT1L

, 2021
Context:Circulating concentrations of free triiodothyronine (fT3), free thyroxine (fT4), and thyrotropin (TSH) are partly heritable traits. Recent studies have advanced knowledge of their genetic architecture.
Mullin, S (15727808), Huang, R-C (15628547), Wilson, SG (15559790), Lafontaine, M (15727802), Lim, EM (15727811), Zhu, G (15519806), Mori, TA (15574103), Bell, JT (15727829), Castillo-Fernandez, JE (15727805), Martin, NG (15519818), Campbell, PJ (15556844), Beilin, LJ (15501392), McRae, AF (15727823), Panicker, V (15727826), Brown, SJ (15603452), Kendrew, P (15727814), Lewer, M (15727817), Spector, TD (15502925), Phillip Melton (14744191), Dudbridge, F (15727820), Wright, MJ (15555971), Walsh, JP (15578009)   +21 more
core  

ERRATUM: Acknowledgments Correction. Cell-Free miR-27a, a Potential Diagnostic and Prognostic Biomarker for Gastric Cancer [PDF]

Genomics & Informatics, 2015
Jong-Lyul Park, Mirang Kim, Kyu-Sang Song, Seon-Young Kim, Yong Sung Kim   +4 more
doaj   +1 more source

The Epigenomics of Pituitary Adenoma

Frontiers in Endocrinology, 2019
Background: The vast majority of pituitary tumors are benign and behave accordingly; however, a fraction are invasive and are more aggressive, with a very small fraction being frankly malignant.
Blake M. Hauser, Ashley Lau, Saksham Gupta, Wenya Linda Bi, Ian F. Dunn   +4 more
doaj   +1 more source

Epigenome-wide meta-analysis of PBMC DNA methylation in three combined cohorts for HIV infection, top 500.

Epigenome-wide meta-analysis of PBMC DNA methylation in three combined cohorts for HIV infection, top 500.
Vincent C. Marconi (8232468), Bradley E. Aouizerat (9678480), Xinyu Zhang (14029), Mardge H. Cohen (7923182), Ral E. Vandenhoudt (18137407), Zuoheng Wang (223293), Ying Hu (14950), Ke Xu (134879), Amy C. Justice (9185633), Chunhua Yan (392686)   +9 more
core   +1 more source

Epigenomics and the Microbiota [PDF]

Toxicologic Pathology, 2014
The mammalian gastrointestinal tract is home to trillions of commensal microorganisms that collectively make up the intestinal microbiota. These microbes are important environmental factors that regulate homeostasis, and alterations in the composition of the microbiota have been associated with several diseases, including inflammatory bowel disease ...
openaire   +2 more sources

Identifying epigenetic aging moderators using the epigenetic pacemaker

Frontiers in Bioinformatics
Epigenetic clocks are DNA methylation-based chronological age prediction models that are commonly employed to study age-related biology. The difference between the predicted and observed age is often interpreted as a form of biological age acceleration ...
Colin Farrell, Chanyue Hu, Kalsuda Lapborisuth, Kyle Pu, Sagi Snir, Matteo Pellegrini   +5 more
doaj   +1 more source