Results 101 to 110 of about 89,797 (267)

The Epigenomics of Pituitary Adenoma

Frontiers in Endocrinology, 2019
Background: The vast majority of pituitary tumors are benign and behave accordingly; however, a fraction are invasive and are more aggressive, with a very small fraction being frankly malignant.
Blake M. Hauser, Ashley Lau, Saksham Gupta, Wenya Linda Bi, Ian F. Dunn   +4 more
doaj   +1 more source

FOXM1 coming of age: time for translation into clinical benefits? [PDF]

, 2012
A decade since the first evidence implicating the cell cycle transcription factor Forkhead Box M1 (FOXM1) in human tumorigenesis, a slew of subsequent studies revealed an oncogenic role of FOXM1 in the majority of human cancers including oral ...
Teh, M-T
core   +1 more source

A Systematic Review of Adverse Childhood Experiences and Epigenetic Age Acceleration in Later Adult Life Measured With Second and Third‐Generation Epigenetic Clocks

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT We examined the relationship between adverse childhood experiences (ACEs) and epigenetic age acceleration (EAA) in adulthood as measured by second and third generation epigenetic clocks by performing a systematic review of the literature. The electronic databases MEDLINE and EMBASE were searched on 17 July 2023.
Matthew Green, Laura Horsfall, Azam Saied   +2 more
wiley   +1 more source

Insertion of short L1 sequences generates inter-strain histone acetylation differences in the mouse

Mobile DNA
Background Gene expression divergence between populations and between individuals can emerge from genetic variations within the genes and/or in the cis regulatory elements.
Beverly Ann G. Boyboy, Kenji Ichiyanagi
doaj   +1 more source

Identifying epigenetic aging moderators using the epigenetic pacemaker

Frontiers in Bioinformatics
Epigenetic clocks are DNA methylation-based chronological age prediction models that are commonly employed to study age-related biology. The difference between the predicted and observed age is often interpreted as a form of biological age acceleration ...
Colin Farrell, Chanyue Hu, Kalsuda Lapborisuth, Kyle Pu, Sagi Snir, Matteo Pellegrini   +5 more
doaj   +1 more source

BayesCCE: a Bayesian framework for estimating cell-type composition from DNA methylation without the need for methylation reference. [PDF]

, 2018
We introduce a Bayesian semi-supervised method for estimating cell counts from DNA methylation by leveraging an easily obtainable prior knowledge on the cell-type composition distribution of the studied tissue. We show mathematically and empirically that
Eskin, Eleazar, Gabel, Eilon, Halperin, Eran, Hofer, Ira, Rahmani, Elior, Schweiger, Regev, Shenhav, Liat, Wingert, Theodora   +7 more
core   +3 more sources

Dietary and biomarker‐guided strategies as supportive measures in the fragile X syndrome

Food Biomacromolecules, EarlyView.
Abstract The fragile X syndrome (FXS) is an inherited neurodevelopmental disorder that primarily affects males, often resulting in an IQ below 55, while about two‐thirds of females also experience intellectual disability. Physical features may include an elongated face, prominent ears, finger joint laxity, and enlarged testes in males.
Jailan E. El Halawani, Reem R. AlOlaby
wiley   +1 more source

ERRATUM: Acknowledgments Correction. Cell-Free miR-27a, a Potential Diagnostic and Prognostic Biomarker for Gastric Cancer [PDF]

Genomics & Informatics, 2015
Jong-Lyul Park, Mirang Kim, Kyu-Sang Song, Seon-Young Kim, Yong Sung Kim   +4 more
doaj   +1 more source

Short-term heavy drinking in a non-human primate model skews monocytes toward a hypo-inflammatory phenotype

Frontiers in Immunology
IntroductionAlcohol use is prevalent in the United States (US), with ~80% of persons over 12 years old reporting alcohol consumption in 2023 and ~10% of those individuals developing alcohol use disorder (AUD).
Madison B. Blanton, Madison B. Blanton, Hami Hemati, Qi Qiao, Qi Qiao, Rupak Khadka, Gregory Hawk, Kathleen A. Grant, Ilhem Messaoudi   +8 more
doaj   +1 more source

SnapShot: Epigenomic Assays

Cell, 2016
This SnapShot depicts key sequencing-based methods used in the analysis of epigenomes, including (1)bisulfite sequencing, (2) chromatin immunoprecipiation sequencing, (3) determination of open chromatin, and (4) 3D chromatin capture.
Martin, Krzywinski, Martin, Hirst
openaire   +2 more sources