Results 71 to 80 of about 63,478 (191)

The Epigenome in Pluripotency and Differentiation [PDF]

Epigenomics, 2014
The ability to culture pluripotent stem cells and direct their differentiation into specific cell types in vitro provides a valuable experimental system for modeling pluripotency, development and cellular differentiation. High-throughput profiling of the transcriptomes and epigenomes of pluripotent stem cells and their differentiated derivatives has ...
Thiagarajan, Rathi D, Morey, Robert, Laurent, Louise C   +2 more
openaire   +4 more sources

DNA methylation profiling of the human major histocompatibility complex: A pilot study for the Human Epigenome Project [PDF]

, 2004
The Human Epigenome Project aims to identify, catalogue, and interpret genome-wide DNA methylation phenomena. Occurring naturally on cytosine bases at cytosine-guanine dinucleotides, DNA methylation is intimately involved in diverse biological processes ...
Gut, IG, Tost, J, Fischer, J, Hildmann, T, Lewin, J, Novik, KL, Beck, S, Cox, AV, Olek, A, Berlin, K, Otto, T, Howe, KL, Andrews, TD, Rakyan, VK   +13 more
core  

Epigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age

, 2020
Preterm birth and shorter duration of pregnancy are associated with increased morbidity in neonatal and later life. The epigenome is known to have an important role during fetal development. The best studied epigenetic modification is DNA methylation. We
Simon Kebede Merid (8354720)
core   +1 more source

Beyond the Exome: The Non-coding Genome and Enhancers in Neurodevelopmental Disorders and Malformations of Cortical Development

Frontiers in Cellular Neuroscience, 2019
The development of the human cerebral cortex is a complex and dynamic process, in which neural stem cell proliferation, neuronal migration, and post-migratory neuronal organization need to occur in a well-organized fashion.
Elena Perenthaler, Soheil Yousefi, Eva Niggl, Tahsin Stefan Barakat   +3 more
doaj   +1 more source

Epigenome-wide meta-analysis of monocyte DNA methylation in three combined cohorts for HIV infection.

Epigenome-wide meta-analysis of monocyte DNA methylation in three combined cohorts for HIV infection.
Vincent C. Marconi (8232468), Bradley E. Aouizerat (9678480), Xinyu Zhang (14029), Mardge H. Cohen (7923182), Ral E. Vandenhoudt (18137407), Zuoheng Wang (223293), Ying Hu (14950), Ke Xu (134879), Amy C. Justice (9185633), Chunhua Yan (392686)   +9 more
core   +1 more source

chroGPS, a global chromatin positioning system for the functional analysis and visualization of the epigenome [PDF]

, 2013
Development of tools to jointly visualize the genome and the epigenome remains a challenge. chroGPS is a computational approach that addresses this question.
Azorin, Fernando, Azorín Marín, Fernando, Reina García, Óscar, 1976-, Reina, Oscar, Azorín, Ferran, Font-Burgada, Joan, Rossell, David   +6 more
core   +1 more source

The aging epigenome

eLife, 2022
A new approach helps to assess the impact of accelerated epigenetic aging on the risk of cancer.
openaire   +3 more sources

Cancer epigenomics [PDF]

Human Molecular Genetics, 2002
Research in cancer epigenomics is driven by the development of novel technologies and the utilization of model organisms ranging from yeasts to plants to vertebrates. For decades, the search for cancer genes has focused on genetic defects that were used as tags for identification of these genes.
openaire   +2 more sources

Epigenome-wide association study of global cortical volumes in generation Scotland: Scottish family health study

, 2021
A complex interplay of genetic and environmental risk factors influence global brain structural alterations associated with brain health and disease.
Stolicyn Aleks (11653938), Xueyi Shen (456147), Gordon Waiter (143361), Douglas Steele (287668), David Porteous (150029), Joanna Wardlaw (259953), Andrew McIntosh (83234), Miruna Carmen Barbu (11653932), Kathryn Evans (3464480), Carmen Amador (122097), Mark Adams (26421), Anca Sandu (11653941), Stewart Morris (3464450), Christopher McNeil (11653944), Mat Harris (11653935), Archie Campbell (669891), Heather Whalley (3464462), Rosie Walker (3464477), Alison Murray (513091), Claire Green (3843865)   +19 more
core   +1 more source

The Viral Immunoshadow: Early Adenovirus Strategies for Cloaking Innate Immunity with E1A, E4orf1, and Beyond

Cells
Human adenovirus (HAdV), a double-stranded DNA virus, targets terminally differentiated cells in the upper respiratory tract. As a key platform for gene therapy vectors, elucidating HAdV’s virulence factors is vital for optimizing therapeutic ...
Marco Vezzoli, Giorgio Dieci, Roberto Ferrari   +2 more
doaj   +1 more source