Results 31 to 40 of about 289,022 (302)
Cfp1 is required for gene expression dependent H3K4me3 and H3K9 acetylation in embryonic stem cells [PDF]
, 2014 BackgroundTrimethylation of histone H3 lysine 4 (H3K4me3) accumulates at promoters in a gene activity dependent manner. The Set1 complex is responsible for most H3K4me3 in somatic cells and contains the conserved subunit Cfp1, which is implicated in ...
Bird, Adrian +2 more
core +1 more source
Crosstalk among Histone Modifications [PDF]
Cell, 2008 Histone modifications play a complex role in the regulation of transcription. Recent studies (Duncan et al., 2008; Lee et al., 2007; Li et al., 2008) reveal that regulation of histone modifications can be functionally linked to reinforce the activation or repression of gene expression.
Suganuma, Tamaki, Workman, Jerry L.
openaire +2 more sources
Frontiers in Oncology, 2019 IPO-38 is a potential biomarker for early diagnosis of gastric cancer that we recently identified. Although we characterized its chemical nature as a nucleosome histone, we suspected the existence of histone modification for the IPO-38 antibody-labeled ...
Shuzheng Song +6 more
doaj +1 more source
Pitfalls in histone propionylation during bottom-up mass spectrometry analysis [PDF]
, 2015 Despite their important role in regulating gene expression, posttranslational histone modifications remain technically challenging to analyze. For identification by bottom-up MS, propionylation is required prior to and following trypsin digestion. Hereby,
Deforce, Dieter +4 more
core +1 more source
Finding combinatorial histone code by semi-supervised biclustering
BMC Genomics, 2012 Background Combinatorial histone modification is an important epigenetic mechanism for regulating chromatin state and gene expression. Given the rapid accumulation of genome-wide histone modification maps, there is a pressing need for computational ...
Teng Li, Tan Kai
doaj +1 more source
Identification of H3K4me1-associated proteins at mammalian enhancers. [PDF]
, 2017 Enhancers act to regulate cell-type-specific gene expression by facilitating the transcription of target genes. In mammalian cells, active or primed enhancers are commonly marked by monomethylation of histone H3 at lysine 4 (H3K4me1) in a cell-type ...
Albuquerque, Claudio P +13 more
core +2 more sources
A role for SUMO modification in transcriptional repression and activation [PDF]
, 2007 Since the discovery of the SUMO (small ubiquitin-like modifier) family of proteins just over a decade ago, a plethora of substrates have been uncovered including many regulators of transcription.
David +26 more
core +1 more source
Scientific Reports, 2022 Post-translational modification of histones is the crucial event that affect many tumor-specific traits. A diverse type of histone modifications had been reported in different cancers with prognostic implications.
Aroonwan Lam-Ubol +1 more
doaj +1 more source
Chromatin changes in response to drought, salinity, heat, and cold stresses in plants
Frontiers in Plant Science, 2015 Chromatin regulation is essential to regulate genes and genome activities. In plants, the alteration of histone modification and DNA methylation are coordinated with changes in the expression of stress-responsive genes to adapt to environmental changes ...
Jong-Myong eKim +8 more
doaj +1 more source
Frontiers in Plant Science, 2015 In eukaryotes, histone acetylation and methylation have been known to be involved in regulating diverse developmental processes and plant defense. These histone modification events are controlled by a series of histone modification gene families. To date,
Jidi eXu +5 more
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