Results 21 to 30 of about 13,098 (199)

KMT2D‐mediated H3K4me1 recruits YBX1 to facilitate triple‐negative breast cancer progression through epigenetic activation of c‐Myc

Clinical and Translational Medicine
Background Lysine methyltransferase 2D (KMT2D) mediates mono‐methylation of histone H3 lysine 4 (H3K4me1) in mammals. H3K4me1 mark is involved in establishing an active chromatin structure to promote gene transcription.
Bing Yao, Mengying Xing, Xiangwei Zeng, Ming Zhang, Que Zheng, Zhi Wang, Bo Peng, Shuang Qu, Lingyun Li, Yucui Jin, Haitao Li, Hongyan Yuan, Quan Zhao, Changyan Ma   +13 more
doaj   +2 more sources

Loss of Function of the Gene Encoding the Histone Methyltransferase KMT2D Leads to Deregulation of Mitochondrial Respiration

Cells, 2020
KMT2D encodes a methyltransferase responsible for histone 3 lysine 4 (H3K4) mono-/di-methylation, an epigenetic mark correlated with active transcription.
Giuseppe Merla, Gabriella Pinto, Nazzareno Capitanio   +2 more
exaly   +3 more sources

Analysis of the role of mutations in the KMT2D histone lysine methyltransferase in bladder cancer

FEBS Open Bio, 2019
Histone lysine methyltransferases (HMT) comprise a subclass of epigenetic regulators; dysregulation of these enzymes affects gene expression, which may lead to tumorigenesis.
Beichen Ding, Libin Yan, Yucong Zhang, Zhize Wang, Yangjun Zhang, Ding Xia, Zhangqun Ye, Hua Xu   +7 more
exaly   +2 more sources

The histone methyltransferase KMT2D is essential for embryo implantation via regulating precise differentiation of endometrial cells

Cell Death Discovery
Embryo implantation failures are a major challenge in reproductive medicine, but the underlying mechanism remains poorly understood. Successful implantation requires dynamic remodeling of the endometrium through integrated proliferation and ...
Ryosuke Kobayashi, Yuki Tajika, Junki Kohmaru, Sumiyo Morita, Takuro Horii, Yoichi Mizukami, Shizu Aikawa, Yasushi Hirota, Izuho Hatada   +8 more
doaj   +2 more sources

Bone Marrow Pathology in Cold Agglutinin-Mediated Autoimmune Hemolytic Anemia: A Study of 56 Cases. [PDF]

Eur J Haematol
ABSTRACT Cold agglutinin disease (CAD) is a rare form of autoimmune hemolytic anemia (AIHA). CAD occurs in the context of a small clonal B‐cell lymphoproliferation restricted to blood and/or bone marrow (BM), without overt or extramedullary lymphoma. The WHO‐HAEM5 introduced a description of the CAD‐associated lymphoproliferative disorder (CAD‐LPD) in ...
Becking AL, Bernelot Moens SJ, Kersten MJ, Mulder FVM, Pals ST, Koens L, Vos JMI.   +6 more
europepmc   +2 more sources

Mapping in silico genetic networks of the KMT2D tumour suppressor gene to uncover novel functional associations and cancer cell vulnerabilities

Genome Medicine
Background Loss-of-function (LOF) alterations in tumour suppressor genes cannot be directly targeted. Approaches characterising gene function and vulnerabilities conferred by such mutations are required.
Yuka Takemon, Erin D. Pleasance, Alessia Gagliardi, Christopher S. Hughes, Veronika Csizmok, Kathleen Wee, Diane L. Trinh, Ryan D. Huff, Andrew J. Mungall, Richard A. Moore, Eric Chuah, Karen L. Mungall, Eleanor Lewis, Jessica Nelson, Howard J. Lim, Daniel J. Renouf, Steven JM. Jones, Janessa Laskin, Marco A. Marra   +18 more
doaj   +2 more sources

Ketogenic diet modifies ribosomal protein dysregulation in KMT2D Kabuki syndrome

eBioMedicine
Summary Background Kabuki syndrome (KS) is a genetic disorder caused by DNA mutations in KMT2D, a lysine methyltransferase that methylates histones and other proteins, and therefore modifies chromatin structure and subsequent gene expression.
E. Tsang, V. Han, Chloe Flutter, S. Alshammery, B. Keating, Tracey Williams, Brian S. Gloss, Mark E. Graham, N. Aryamanesh, I. Pang, Melanie Wong, David S. Winlaw, Michael Cardamone, S. Mohammad, Wendy Gold, Shrujna Patel, Russell C Dale   +16 more
semanticscholar   +3 more sources

Cancer-epigenetic function of the histone methyltransferase KMT2D and therapeutic opportunities for the treatment of KMT2D-deficient tumors [PDF]

Oncotarget, 2021
Epigenetic mechanisms are central to understanding the molecular basis underlying tumorigenesis. Aberrations in epigenetic modifiers alter epigenomic landscapes and play a critical role in tumorigenesis. Notably, the histone lysine methyltransferase KMT2D (a COMPASS/ Set1 family member; also known as MLL4, ALR, and MLL2) is among the most frequently ...
Dhar, Shilpa S., Lee, Min Gyu
openaire   +2 more sources

PI 3-Kinase and the Histone Methyl-Transferase KMT2D Collaborate to Induce Arp2/3-Dependent Migration of Mammary Epithelial Cells

Cells
Breast cancer develops upon sequential acquisition of driver mutations in mammary epithelial cells; however, how these mutations collaborate to transform normal cells remains unclear in most cases.
Karina D. Rysenkova, Julia Gaboriaud, Artem I. Fokin, Raphaëlle Toubiana, Alexandre Bense, Camil Mirdass, Mélissa Jin, Minh Chau N. Ho, Elizabeth Glading, Sophie Vacher, Laura Courtois, Ivan Bièche, Alexis M. Gautreau   +12 more
doaj   +2 more sources

KMT2D Regulates the NCOA6/THRB Signal Axis through Epigenetic Modification to Promote the Migration and Invasion of Papillary Thyroid Cancer

Frontiers in Bioscience-Landmark, 2023
Background: The histone lysine methyltransferase Histone-lysine N-methytransferase 2D (KMT2D) is a common mutated gene in a variety of cancers, including papillary thyroid cancer (PTC).
Rui Wang, Yibo He, Yi Wang, Shangnao Xie
doaj   +1 more source