Results 1 to 10 of about 16,350 (151)
H3K4me1 directs H3K36me2 and H3K36me3 deposition in land plants [PDF]
Nature CommunicationsMonomethylation of histone 3 lysine 4 (H3K4me1) marks enhancers in mammals. However, the function of H3K4me1 in plants remains largely unclear. Here, we present the genome-wide distribution of H3K4me1 in diverse species across evolution, revealing a ...
Jiabing Wu +16 more
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Cancer Biology and Therapy, 2023 Pancreatic adenocarcinoma (PAAD) is a major cause of mortality related to cancer worldwide. This paper dissected the functions of the CSTF2T/ASH2L/CALB2 axis in PAAD progression.
Bo Xu
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H3K27me3-H3K4me1 transition at bivalent promoters instructs lineage specification in development
Cell and Bioscience, 2023 Background Bivalent genes, of which promoters are marked by both H3K4me3 (trimethylation of histone H3 on lysine 4) and H3K27me3 (trimethylation of histone H3 on lysine 27), play critical roles in development and tumorigenesis.
, Xinjie Li, Li Xinjie
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H3K4me1 Distribution Predicts Transcription State and Poising at Promoters [PDF]
Frontiers in Cell and Developmental Biology, 2020 Monomethylation on lysine 4 of histone H3 (H3K4me1) is commonly associated with distal enhancers, but H3K4me1 is also present at promoter regions proximal to transcription start sites.
Bluma J Lesch, Sunhee Bae
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SETD7-mediated H3K4me1 activates ALDH1A3 to drive ferroptosis resistance in esophageal squamous cell carcinoma [PDF]
Cell Death and DiseaseSET domain-containing 7 (SETD7, also known as KMT7 or SET7/9), a histone lysine methyltransferase (HKMT) responsible for catalyzing histone H3 lysine 4 monomethylation (H3K4me1), has emerged as a key regulator in multiple cancers. However, the biological
Yang Feng +10 more
doaj +4 more sources
DNA methylation regulates discrimination of enhancers from promoters through a H3K4me1-H3K4me3 seesaw mechanism [PDF]
BMC Genomics, 2017 Background DNA methylation at promoters is largely correlated with inhibition of gene expression. However, the role of DNA methylation at enhancers is not fully understood, although a crosstalk with chromatin marks is expected.
Hossein Baharvand +2 more
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EBF2 Links KMT2D‐Mediated H3K4me1 to Suppress Pancreatic Cancer Progression via Upregulating KLLN
Advanced Science, 2023 Mono‐methylation of histone H3 on Lys 4 (H3K4me1), which is catalyzed by histone‐lysine N‐methyltransferase 2D (KMT2D), serves as an important epigenetic regulator in transcriptional control.
Changyan Ma
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Cells, 2019 Background: Retroelements (REs) are mobile genetic elements comprising ~40% of human DNA. They can reshape expression patterns of nearby genes by providing various regulatory sequences.
Philipp Kopylov +2 more
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Sequencing DNA methylation and hydroxymethylation at co-occurring chromatin features [PDF]
Nature CommunicationsEpigenetic modifications govern chromatin dynamics and cell state. However, current methods cannot simultaneously resolve the presence of multiple DNA modifications at co-occurring chromatin-associated features.
Rafael de Cesaris Araujo Tavares +9 more
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Clinical and Translational MedicineBackground Lysine methyltransferase 2D (KMT2D) mediates mono‐methylation of histone H3 lysine 4 (H3K4me1) in mammals. H3K4me1 mark is involved in establishing an active chromatin structure to promote gene transcription.
Changyan Ma, Bing Yao, Mengying Xing
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