Results 31 to 40 of about 16,350 (151)

Loss of MLL3/4 decouples enhancer H3K4 monomethylation, H3K27 acetylation, and gene activation during embryonic stem cell differentiation

Genome Biology, 2023
Background Enhancers are essential in defining cell fates through the control of cell-type-specific gene expression. Enhancer activation is a multi-step process involving chromatin remodelers and histone modifiers including the monomethylation of H3K4 ...
Ryan M. Boileau, Kevin X. Chen, Robert Blelloch   +2 more
doaj   +1 more source

Prediction accuracy of regulatory elements from sequence varies by functional sequencing technique

Frontiers in Cellular and Infection Microbiology, 2023
IntroductionVarious sequencing based approaches are used to identify and characterize the activities of cis-regulatory elements in a genome-wide fashion.
Ronald J. Nowling, Kimani Njoya, John G. Peters, Michelle M. Riehle   +3 more
doaj   +1 more source

Enhancer Chromatin and 3D Genome Architecture Changes from Naive to Primed Human Embryonic Stem Cell States

Stem Cell Reports, 2019
Summary: During mammalian embryogenesis, changes in morphology and gene expression are concurrent with epigenomic reprogramming. Using human embryonic stem cells representing the preimplantation blastocyst (naive) and postimplantation epiblast (primed ...
Stephanie L. Battle, Naresh Doni Jayavelu, Robert N. Azad, Jennifer Hesson, Faria N. Ahmed, Eliah G. Overbey, Joseph A. Zoller, Julie Mathieu, Hannele Ruohola-Baker, Carol B. Ware, R. David Hawkins   +10 more
doaj   +1 more source

Transcription-coupled and epigenome-encoded mechanisms direct H3K4 methylation

Nature Communications, 2022
Methylation of histone H3 lysine 4 is associated with transcription. Here the authors describe three Arabidopsis methyltransferases that direct H3K4me1 and propose that one methyltransferase works co-transcriptionally while the others are recruited to ...
Satoyo Oya, Mayumi Takahashi, Kazuya Takashima, Tetsuji Kakutani, Soichi Inagaki   +4 more
doaj   +1 more source

Genome-Wide Enhancer Analysis Reveals the Role of AP-1 Transcription Factor in Head and Neck Squamous Cell Carcinoma

Frontiers in Molecular Biosciences, 2021
Head and neck squamous cell carcinoma (HNSCC) is one of the most common cancers in the world, but its epigenomic features have not been determined. Here, we studied the chromatin landscape of active enhancers of HNSCC head tumor tissues by performing ...
Chen-Yu Wang, Guang-Tao Yu, Chuan Gao, Ji Chen, Qing-Lan Li, Lu Zhang, Min Wu, Zhi-Jun Sun, Lian-Yun Li   +8 more
doaj   +1 more source

H3K4 mono- and di-methyltransferase MLL4 is required for enhancer activation during cell differentiation

eLife, 2013
Enhancers play a central role in cell-type-specific gene expression and are marked by H3K4me1/2. Active enhancers are further marked by H3K27ac. However, the methyltransferases responsible for H3K4me1/2 on enhancers remain elusive. Furthermore, how these
Ji-Eun Lee, Chaochen Wang, Shiliyang Xu, Young-Wook Cho, Lifeng Wang, Xuesong Feng, Anne Baldridge, Vittorio Sartorelli, Lenan Zhuang, Weiqun Peng, Kai Ge   +10 more
doaj   +1 more source

MLL3 is a de novo cause of endocrine therapy resistance

Cancer Medicine, 2021
Background Cancer resequencing studies have revealed epigenetic enzymes as common targets for recurrent mutations. The monomethyltransferase MLL3 is among the most recurrently mutated enzymes in ER+ breast cancer.
Kimberly M. Stauffer, David L. Elion, Rebecca S. Cook, Thomas Stricker   +3 more
doaj   +1 more source

H3K4me1 marks DNA regions hypomethylated during aging in human stem and differentiated cells

Genome Research, 2014
In differentiated cells, aging is associated with hypermethylation of DNA regions enriched in repressive histone post-translational modifications. However, the chromatin marks associated with changes in DNA methylation in adult stem cells during lifetime are still largely unknown.
Fernández, Agustín F., Bayón, Gustavo F., Urdinguio, Rocío G., Toraño, Estela G., García, María G., Carella, Antonella, Petrus-Reurer, Sandra, Ferrero, Cecilia, Martínez Camblor, Pablo, Cubillo, Isabel, García Castro, Javier, Delgado Calle, Jesús, Pérez-Campo, Flor M., Riancho, José A., Bueno, Clara, Menéndez Buján, Pablo, Mentink, Anouk, Mareschi, Katia, Claire, Fabian, Fagnani, Corrado, Medda, Emanuela, Toccaceli, Virgilia, Brescianini, Sonia, Moran, Sebastian, Esteller, Manel, Stolzing, Alexandra, Boer, Jan de, Nistico, Lorenza, Stazi, Maria A., Fraga, Mario F.   +29 more
openaire   +6 more sources

Integrative Omics Analysis Reveals the Regulation of Hypoxia Tolerance in Large Yellow Croaker (Larimichthys crocea) via the Lipoic Acid Synthase (lias) Gene

Advanced Science, EarlyView.
Lipoic acid synthase (lias) can regulate α‐KG levels through lipoylation, thereby negatively regulating HIF‐1α protein levels via PHD under hypoixa. The Hap2 allele of lias exhibits lower expression levels than Hap1, leading to the accumulation of more HIF‐1α protein and thereby enhancing hypoxia tolerance. ABSTRACT Hypoxia stress seriously affects the
Jie Ding, Songpeng Jia, Ran Meng, Xuelei Wang, Xiongfei Wu, Weiliang Shen, Yibo Zhang, Junquan Zhu   +7 more
wiley   +1 more source

RHINO: An Integrative Multi‐Omics Framework Linking Circadian Physiology to Precision Medicine

Advanced Science, EarlyView.
RHINO (RHythmic Interacting Network for multi‐Omics) is an integrative framework that maps circadian regulation across diverse genetic and disease contexts and prioritizes druggable circadian targets. Released as an AI‐powered interactive web portal, RHINO unifies genetic, regulatory, disease, and drug–target information, enabling context‐specific ...
Ying Chen, Chengxuan Chen, Dishu Zhou, Panpan Liu, Roberto E. López‐Valiente, Yuan Liu, Cam Mong La, Isabella Beraldo Xavier, Sean M. Hartig, Pradip Saha, Zheng Sun, Leng Han, Dongyin Guan   +12 more
wiley   +1 more source