Results 21 to 30 of about 16,350 (151)
Cell Reports, 2020 Summary: An aberrant increase in pluripotency gene (PpG) expression due to enhancer reactivation could induce stemness and enhance the tumorigenicity of cancer stem cells.
Lama AlAbdi +10 more
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Identification and Characterisation of Putative Enhancer Elements in Mouse Embryonic Stem Cells
Bioinformatics and Biology Insights, 2021 Enhancer elements control mammalian transcription largely in a cell-type-specific manner. The genome-wide identification of enhancer elements and their activity status in a cellular context is therefore fundamental to understanding cell identity and ...
Anna Mantsoki +2 more
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High Dietary Salt Intake Is Associated With Histone Methylation in Salt-Sensitive Individuals
Frontiers in Nutrition, 2022 BackgroundHigh salt diet is one of the important risk factors of hypertension and cardiovascular diseases. Increasingly strong evidence supports epigenetic mechanisms' significant role in hypertension. We aimed to explore associations of epigenetics with
Yueyuan Liao +29 more
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BMC Genomics, 2023 Background DNA hypermethylation at promoter CpG islands (CGIs) is a hallmark of cancers and could lead to dysregulation of gene expression in the development of cancers, however, its dynamics and regulatory mechanisms remain elusive. Bivalent genes, that
Yang Lu +5 more
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iScience, 2023 Summary: Phenotypic dimorphism between queens and workers is an important biological characteristic of honeybees that has been the subject of intensive research.
Meng Jie Jin +9 more
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Lysine methyltransferase Kmt2d regulates naive CD8+ T cell activation-induced survival
Frontiers in Immunology, 2023 Lysine specific methyltransferase 2D (Kmt2d) catalyzes the mono-methylation of histone 3 lysine 4 (H3K4me1) and plays a critical role in regulatory T cell generation via modulating Foxp3 gene expression.
Jaekwan Kim +12 more
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PLoS Genetics, 2021 In mammals, cellular identity is defined through strict regulation of chromatin modifications and DNA methylation that control gene expression. Methylation of cytosines at CpG sites in the genome is mainly associated with suppression; however, the reason
Adi Alajem +7 more
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Histone H3K4me1 strongly activates the DNase I hypersensitive sites in super-enhancers than those in typical enhancers [PDF]
Bioscience Reports, 2021 Abstract Super-enhancers (SEs), which consist of multiple enhancer elements, are occupied by master transcription factors and co-activators, such as Mediator, and are highly acetylated at histone H3K27. Here, we have characterized the SEs in terms of DNase I hypersensitive sites (DHSs) by analyzing publicly available chromatin ...
Yujin Kang, Jin Kang, AeRi Kim
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Characterization of Chromatin Structure-associated Histone Modifications in Breast Cancer Cells [PDF]
Genomics & Informatics, 2012 Chromatin structure and dynamics that are influenced by epigenetic marks, such as histone modification and DNA methylation, play a crucial role in modulating gene transcription.
Chang Pyo Hong +2 more
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Inhibition of the H3K4 methyltransferase SET7/9 ameliorates peritoneal fibrosis. [PDF]
PLoS ONE, 2018 Transforming growth factor-β1 (TGF-β1) is a major mediator of peritoneal fibrosis and reportedly affects expression of the H3K4 methyltransferase, SET7/9.
Ryo Tamura +6 more
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