Results 11 to 20 of about 16,350 (151)

H3K4me1 Supports Memory-like NK Cells Induced by Systemic Inflammation [PDF]

Cell Reports, 2019
Summary: Natural killer (NK) cells are unique players in innate immunity and, as such, an attractive target for immunotherapy. NK cells display immune memory properties in certain models, but the long-term status of NK cells following systemic ...
Melanie Hamon, Jean-Marc Cavaillon, Catherine Fitting   +2 more
exaly   +6 more sources

FOXM1 maintains fatty acid homoeostasis through the SET7-H3K4me1-FASN axis

Cell Death Discovery, 2023
Reprogramming of metabolic genes and subsequent alterations in metabolic phenotypes occur widely in malignant tumours, including glioblastoma (GBM). FOXM1 is a potent transcription factor that plays an oncogenic role by regulating the expression of many ...
Xixi Li, Weijie Su, Honglin Wu, Jiakun Xu, Hongxing Tang, Xiangkun Chen, Zhanqi Yin, Changming Zhang, Jia Yang, Yibing Yang, Nu Zhang, Lixuan Yang   +11 more
doaj   +3 more sources

Single-cell profiling of H3K4me1-H3K27me3 revealed bivalent regulation of abnormal neuronal development caused by prenatal e-cigarette vaporing [PDF]

Communications Biology
Histone H3K4me1 and H3K27me3 modifications play a crucial role in regulating neuronal development by maintaining the balance between active and inactive genes during neurogenesis.
Zhong Chen, Lijuan Song, Wanqiu Chen, Charles Wang   +3 more
doaj   +2 more sources

Global mapping of H3K4me1 and H3K4me3 reveals the chromatin state-based cell type-specific gene regulation in human Treg cells. [PDF]

PLoS ONE, 2011
Regulatory T cells (Treg) contribute to the crucial immunological processes of self-tolerance and immune homeostasis. Genomic mechanisms that regulate cell fate decisions leading to Treg or conventional T cells (Tconv) lineages and those underlying Treg ...
Yi Tian, Zhengcai Jia, Jun Wang, Zemin Huang, Jun Tang, Yanhua Zheng, Yan Tang, Qinghong Wang, Zhiqiang Tian, Di Yang, Yi Zhang, Xiaolan Fu, Jianxun Song, Shunli Liu, Jennifer C van Velkinburgh, Yuzhang Wu, Bing Ni   +16 more
doaj   +4 more sources

HNF4A guides the MLL4 complex to establish and maintain H3K4me1 at gene regulatory elements

Communications Biology
Hepatocyte nuclear factor 4A (HNF4A/NR2a1), a transcriptional regulator of hepatocyte identity, controls genes that are crucial for liver functions, primarily through binding to enhancers.
Avinash Thakur, Kwangjin Park, Rebecca Cullum, Bettina M. Fuglerud, Mina Khoshnoodi, Sibyl Drissler, Tabea L. Stephan, Jeremy Lotto, Donghwan Kim, Frank J. Gonzalez, Pamela A. Hoodless   +10 more
doaj   +3 more sources

Epigenome and transcriptome changes in KMT2D-related Kabuki syndrome Type 1 iPSCs, neuronal progenitors and cortical neurons. [PDF]

PLoS Genetics
Kabuki syndrome type 1 (KS1) is a neurodevelopmental disorder caused by loss-of-function variants in KMT2D which encodes a H3K4 methyltransferase. The mechanisms underlying neurodevelopmental problems in KS1 are still largely unknown.
Sara Cuvertino, Evgenii Martirosian, Kedar Bhosale, Peiwen Cheng, Terence Garner, Ian J Donaldson, Adam Jackson, Adam Stevens, Andrew D Sharrocks, Susan J Kimber, Siddharth Banka   +10 more
doaj   +2 more sources

H3K4Me1-mediated IGF2BP1 expression aggravates tumor immune evasion and paclitaxel resistance in nasopharyngeal carcinoma

European Journal of Medical Research
Background Our previous study indicated that IGF2BP1 involves in the regulation of resistance in nasopharyngeal carcinoma (NPC) to paclitaxel. The objective of this study is to clarify the molecular mechanisms. Methods H3K4Me1 modification at the IGF2BP1
Chong Zhao, Wentao Wang, Yang Tian, Bingjie Tang, Jing Luo, Jianhui Zhang   +5 more
doaj   +2 more sources

KMT2C/KMT2D-dependent H3K4me1 mediates changes in DNA replication timing and origin activity during a cell fate transition

Cell Reports
Summary: Mammalian genomes replicate in a cell-type-specific order during the S phase, correlated to transcriptional activity, histone modifications, and chromatin structure. The causal relationships between these features and DNA replication timing (RT),
Deniz Gökbuget, Liana Goehring, Ryan M. Boileau, Kayla Lenshoek, Tony T. Huang, Robert Blelloch   +5 more
doaj   +3 more sources

Histone H3K4me1 and H3K27ac play roles in nucleosome depletion and eRNA transcription, respectively, at enhancers [PDF]

The FASEB Journal, 2021
ABSTRACT Histone H3K4me1 and H3K27ac are enhancer specific modifications and are required for enhancers to activate transcription of target genes. However the reciprocal effects of these histone modifications on each other and their roles in enhancers are not clear.
Yujin, Kang, Yea Woon, Kim, Jin, Kang, AeRi, Kim   +3 more
openaire   +2 more sources

H3K4me1 Modification Functions in Caste Differentiation in Honey Bees

International Journal of Molecular Sciences, 2023
Honey bees are important species for the study of epigenetics. Female honey bee larvae with the same genotype can develop into phenotypically distinct organisms (sterile workers and fertile queens) depending on conditions such as diet. Previous studies have shown that DNA methylation and histone modification can establish distinct gene expression ...
Yong Zhang, Zhen Li, Xujiang He, Zilong Wang, Zhijiang Zeng   +4 more
openaire   +2 more sources