Results 51 to 60 of about 16,350 (151)

Role of the tomato MARS1/ROUGH gene encoding a LYSINE‐SPECIFIC HISTONE DEMETHYLASE 1 in adventitious root and fruit skin formation

Journal of Integrative Plant Biology, EarlyView.
The tomato mars1/rough mutant displays enhanced root regeneration and rough fruits due to ectopic cell proliferation. The causal gene encodes a lysine‐specific histone demethylase that normally maintains gene silencing. Its loss alters histone methylation, upregulating several genes, including those B‐type cyclins involved in tissue‐specific cellular ...
Eduardo Larriba, Cécile Bres, Aurora Alaguero‐Cordovilla, Riyazuddin Riyazuddin, Qingyi Wang, Johann Petit, Jean‐Philippe Mauxion, Lara Caballero, David Latrasse, Bénédicte Bakan, Rim Brik‐Chaouche, David Esteve‐Bruna, Moussa Benhamed, Christophe Rothan, José Manuel Pérez‐Pérez   +14 more
wiley   +1 more source

Locus co-occupancy, nucleosome positioning, and H3K4me1 regulate the functionality of FOXA2-, HNF4A-, and PDX1-bound loci in islets and liver [PDF]

Genome Research, 2010
The liver and pancreas share a common origin and coexpress several transcription factors. To gain insight into the transcriptional networks regulating the function of these tissues, we globally identify binding sites for FOXA2 in adult mouse islets and liver, PDX1 in islets, and HNF4A in liver.
Hoffman, Brad G., Robertson, Gordon, Zavaglia, Bogard, Beach, Mike, Cullum, Rebecca, Lee, Sam, Soukhatcheva, Galina, Li, Leping, O'Connor, Elizabeth (R15445), Thiessen, Nina, Bilenky, Mikhail, Cezard, Timothee, Tam, Angela, Kamoh, Baljit, Birol, Inanc, Dai, Derek, Zhao, Yongjun, Hirst, Martin, Verchere, C. Bruce, Helgason, Cheryl D., Marra, Marco A., Jones, Steven, Hoodless, Pamela A.   +22 more
openaire   +3 more sources

The TrxG Complex Mediates Cytokine Induced De Novo Enhancer Formation in Islets. [PDF]

PLoS ONE, 2015
To better understand how β-cells respond to proinflammatory cytokines we mapped the locations of histone 3 lysine 4 monomethylation (H3K4me1), a post-translational histone modification enriched at active and poised cis-regulatory regions, in IFNγ, Il-1β,
Bryan R Tennant, Peter Hurley, Jasmine Dhillon, Amol Gill, Cheryl Whiting, Brad G Hoffman   +5 more
doaj   +1 more source

63438 Differential chromatin accessibility at dorsal root ganglia enhancers is associated with nerve injury

Journal of Clinical and Translational Science, 2021
IMPACT: Our improved understanding of the changes in chromatin accessibility that occur in persistent pain states may identify regulatory genomic elements that play essential roles in modulating gene expression in the DRG.
Kimberly E. Stephens, Weiqiang Zhou, Zhicheng Ji, Hongkai Ji, Yun Guan, Sean D. Taverna   +5 more
doaj   +1 more source

Born early, age fast: Consequences of premature birth on chronic disease and accelerated ageing

The Journal of Physiology, EarlyView.
Abstract figure legend ELGANs are exposed to several postnatal pro‐oxidant stressors, including ambient and supplemental oxygen, mechanical ventilation, infections, hyperalimentation, excessive glucocorticoids and intermittent hypoxia. Since endogenous antioxidant defences are underdeveloped, this imbalance promotes oxidative stress and inflammation ...
Estelle B. Gauda, Julijana Ivanovska, Dwayne Mascarenhas, Jeffrey Antwi, Atefeh Mohammadi, Bonny Jasani   +5 more
wiley   +1 more source

Maternal and zygotic contributions to H3K4me1 chromatin marking during germ layer formation

Developmental Biology
An early step in triploblastic embryo differentiation is the formation of the three germ layers. Maternal pioneer transcription factors (TFs) bind to embryonic enhancers before zygotic genome activation, initiating germ layer specification. While maternal TFs' role in establishing epigenetic marks is known, how early pluripotent cells gain spatially ...
Kitt D. Paraiso, Ira L. Blitz, Ken W.Y. Cho   +2 more
openaire   +4 more sources

Binding Specificity of ASHH2 CW Domain Toward H3K4me1 Ligand Is Coupled to Its Structural Stability Through Its α1-Helix

Frontiers in Molecular Biosciences, 2022
The CW domain binds to histone tail modifications found in different protein families involved in epigenetic regulation and chromatin remodeling. CW domains recognize the methylation state of the fourth lysine on histone 3 and could, therefore, be viewed as a reader of epigenetic information.
Maxim S. Bril’kov, Maxim S. Bril’kov, Olena Dobrovolska, Øyvind Ødegård-Fougner, Øyvind Ødegård-Fougner, Diana C. Turcu, Øyvind Strømland, Jarl Underhaug, Rein Aasland, Øyvind Halskau   +9 more
openaire   +6 more sources

Report on the 13th international workshop on the CCN family of genes and inaugural ARBIOCOM conference, Nice, France

Journal of Cell Communication and Signaling, Volume 20, Issue 3, September 2026.
Celebration of the 13th ICCNS meeting joint to the 1st ARBIOCOM Conference held on the site of Nice in December 2025. Abstract The 13th International Workshop on the CCN Family of Genes, held in Nice as part of the inaugural ARBIOCOM World Conference, brought together investigators with diverse research backgrounds, disciplines, and expertise. Building
Bernard Perbal, Ralf Weiskirchen, Annick Perbal, Brahim Chaqour   +3 more
wiley   +1 more source

Molecular mechanisms of Guadecitabine induced FGFR4 down regulation in alveolar rhabdomyosarcomas

Neoplasia: An International Journal for Oncology Research, 2020
Fibroblast growth factor receptor 4 (FGFR4) aberrant expression and activity have been linked to the pathogenesis of a variety of cancers including rhabdomyosarcomas (RMS).
Emad Darvishi, Katherine Slemmons, Zesheng Wan, Sheetal Mitra, Xiaogang Hou, Jean Hugues Parmentier, Yong-Hwee Eddie Loh, Lee J. Helman   +7 more
doaj   +1 more source

Prostate Cancer Development, Progression, and Therapy

MedComm – Oncology, Volume 5, Issue 3, September 2026.
This review provides an integrated overview of prostate cancer development, progression, and therapy, spanning historical milestones, molecular mechanisms, advanced research models, and emerging therapeutic strategies. It highlights recent advances in precision diagnosis, lineage plasticity, therapy resistance, and next‐generation treatments for ...
Xin Jin, Zicheng Xiao, Zexian Ding, Wei Li, Ruijiang Zeng, Yujun Shuai, Weimin Ci, Dan Xia, Xu Zhang, Haojie Huang   +9 more
wiley   +1 more source