Results 71 to 80 of about 16,350 (151)

Identification of cis regulatory features in the embryonic zebrafish genome through large-scale profiling of H3K4me1 and H3K4me3 binding sites

Developmental Biology, 2011
An organism's genome sequence serves as a blueprint for the proteins and regulatory RNAs essential for cellular function. The genome also harbors cis-acting non-coding sequences that control gene expression and are essential to coordinate regulatory programs during embryonic development.
Aday, Aaron W., Zhu, Lihua Julie, Lakshmanan, Abirami, Wang, Jie, Lawson, Nathan D.   +4 more
openaire   +3 more sources

Transcription and Replication Result in Distinct Epigenetic Marks Following Repression of Early Gene Expression

Frontiers in Genetics, 2013
Simian Virus 40 (SV40) early transcription is repressed when the product of early transcription, T-antigen, binds to its cognate regulatory sequence, Site I, in the promoter of the SV40 minichromosome.
Les eKallestad, Emily eWoods, Kendra eChristensen, Amanda eGefroh, Lata eBalakrishnan, Barry eMilavetz   +5 more
doaj   +1 more source

The case for targeting enhancer regions in high‐risk TCF3::HLF‐positive B‐cell acute lymphoblastic leukemia

HemaSphere, Volume 10, Issue 8, August 2026.
Zahra Sheybani, Charles E. de Bock
wiley   +1 more source

Abstract 164: Enhancer regulation by H3K4me1 methyltransferases

Journal of Biological Chemistry, 2023
openaire   +1 more source

Detection of Genome‐Wide IGF‐1R Recruitment to Enhancer and Promoter Regions of Chromatin in Clinical Prostate Cancers

Cancer Medicine
Introduction Nuclear insulin‐like growth factor‐1 receptor (IGF‐1R) undergoes IGF‐induced recruitment to cancer cell chromatin in vitro and associates with advanced prostate cancer (PCa) stage in clinical tissue, prompting this investigation of IGF‐1R ...
Jack V. Mills, Avigail Taylor, Reema Singh, Jinseon Kim, Simon Engledow, Richard Colling, Clare Verrill, Ian G. Mills, Valentine M. Macaulay   +8 more
doaj   +1 more source

Single-cell multi-omics delineates the dynamics of distinct epigenetic codes coordinating mouse gastrulation

BMC Genomics
Gastrulation represents a crucial stage in embryonic development and is tightly controlled by a complex network involving epigenetic reprogramming. However, the molecular coordination among distinct epigenetic layers entailing the progressive restriction
Mingzhu Fu, Long Pang, Zhenwei Wu, Mei Wang, Jin Jin, Shanshan Ai, Xin Li   +6 more
doaj   +1 more source

The scaffolding function of LSD1 controls DNA methylation in mouse ESCs

Nature Communications
Lysine-specific histone demethylase 1 (LSD1), which demethylates mono- or di- methylated histone H3 on lysine 4 (H3K4me1/2), is essential for early embryogenesis and development.
Sandhya Malla, Kanchan Kumari, Carlos A. García-Prieto, Jonatan Caroli, Anna Nordin, Trinh T. T. Phan, Devi Prasad Bhattarai, Carlos Martinez-Gamero, Eshagh Dorafshan, Stephanie Stransky, Damiana Álvarez-Errico, Paulina Avovome Saiki, Weiyi Lai, Cong Lyu, Ludvig Lizana, Jonathan D. Gilthorpe, Hailin Wang, Simone Sidoli, Andre Mateus, Dung-Fang Lee, Claudio Cantù, Manel Esteller, Andrea Mattevi, Angel-Carlos Roman, Francesca Aguilo   +24 more
doaj   +1 more source

RepEnTools: an automated repeat enrichment analysis package for ChIP-seq data reveals hUHRF1 Tandem-Tudor domain enrichment in young repeats

Mobile DNA
Background Repeat elements (REs) play important roles for cell function in health and disease. However, RE enrichment analysis in short-read high-throughput sequencing (HTS) data, such as ChIP-seq, is a challenging task.
Michel Choudalakis, Pavel Bashtrykov, Albert Jeltsch   +2 more
doaj   +1 more source

Additional file 2 of H3K27me3-H3K4me1 transition at bivalent promoters instructs lineage specification in development

Additional file 2: Figure S2. Bivalent promoter CGIs undergo H3K27me3-H3K4me1 transition during development. A Heatmaps showing H3K4me1, H3K4me3 and H3K27me3 patterns of promoter CGIs and their shores in bivalent cluster in hESC, normal human lung fibroblasts (NHLF) and other human tissues (liver, spleen, stomach, small intestine and pancreas).
Yu, Yue, Li, Xinjie, Jiao, Rui, Lu, Yang, Jiang, Xuan, Li, Xin   +5 more
openaire   +1 more source

Additional file 3 of H3K27me3-H3K4me1 transition at bivalent promoters instructs lineage specification in development

Additional file 3: Figure S3. H3K27me3-H3K4me1 transition influences tissue-specific gene expression. A Top panel: boxplots showing the differences of H3K4me1, H3K4me3 and H3K27me3 on promoters of tissue specific genes between hESC and liver. All Other: all the other tissues without liver.
Yu, Yue, Li, Xinjie, Jiao, Rui, Lu, Yang, Jiang, Xuan, Li, Xin   +5 more
openaire   +1 more source