Results 21 to 30 of about 38,510 (187)

The histone and non-histone methyllysine reader activities of the UHRF1 tandem Tudor domain are dispensable for the propagation of aberrant DNA methylation patterning in cancer cells

Epigenetics & Chromatin, 2020
The chromatin-binding E3 ubiquitin ligase ubiquitin-like with PHD and RING finger domains 1 (UHRF1) contributes to the maintenance of aberrant DNA methylation patterning in cancer cells through multivalent histone and DNA recognition.
Robert M. Vaughan, Ariana Kupai, Caroline A. Foley, Cari A. Sagum, Bailey M. Tibben, Hope E. Eden, Rochelle L. Tiedemann, Christine A. Berryhill, Varun Patel, Kevin M. Shaw, Krzysztof Krajewski, Brian D. Strahl, Mark T. Bedford, Stephen V. Frye, Bradley M. Dickson, Scott B. Rothbart   +15 more
doaj   +1 more source

RFX1 downregulation contributes to TLR4 overexpression in CD14+ monocytes via epigenetic mechanisms in coronary artery disease

Clinical Epigenetics, 2019
Background Toll-like receptor 4 (TLR4) expression is increased in activated monocytes, which play a critical role in the pathogenesis of coronary artery disease (CAD). However, the mechanism remains unclear.
Pei Du, Keqin Gao, Yu Cao, Shuang Yang, Yang Wang, Ren Guo, Ming Zhao, Sujie Jia   +7 more
doaj   +1 more source

Properly substituted analogues of BIX-01294 lose inhibition of G9a histone methyltransferase and gain selective anti-DNA methyltransferase 3A activity. [PDF]

PLoS ONE, 2014
Chemical manipulations performed on the histone H3 lysine 9 methyltransferases (G9a/GLP) inhibitor BIX-01294 afforded novel desmethoxyquinazolines able to inhibit the DNA methyltransferase DNMT3A at low micromolar levels without any significant ...
Dante Rotili, Domenico Tarantino, Biagina Marrocco, Christina Gros, Véronique Masson, Valérie Poughon, Fréderic Ausseil, Yanqi Chang, Donatella Labella, Sandro Cosconati, Salvatore Di Maro, Ettore Novellino, Michael Schnekenburger, Cindy Grandjenette, Celine Bouvy, Marc Diederich, Xiaodong Cheng, Paola B Arimondo, Antonello Mai   +18 more
doaj   +1 more source

Selective targeting of histone modification fails to prevent graft versus host disease after hematopoietic cell transplantation. [PDF]

PLoS ONE, 2018
Allogeneic hematopoietic cell transplantation is often complicated by graft versus host disease (GvHD), primarily mediated through allo-reactive donor T cells in the donor stem cell graft.
Bader Alahmari, Matthew Cooper, Edward Ziga, Julie Ritchey, John F DiPersio, Jaebok Choi   +5 more
doaj   +1 more source

Multiple Histone Lysine Methyltransferases Are Required for the Establishment and Maintenance of HIV-1 Latency

mBio, 2017
We showed previously that the histone lysine methyltransferase (HKMT) H3K27me3 (EZH2) is the catalytic subunit of Polycomb repressive complex 2 (PRC2) and is required for the maintenance of HIV-1 latency in Jurkat T cells.
Kien Nguyen, Biswajit Das, Curtis Dobrowolski, Jonathan Karn   +3 more
doaj   +1 more source

Histone Methyltransferase SETD1A Induces Epithelial-Mesenchymal Transition to Promote Invasion and Metastasis Through Epigenetic Reprogramming of Snail in Gastric Cancer

Frontiers in Cell and Developmental Biology, 2021
Aberrant epigenetic modification induces oncogene expression and promotes cancer development. The histone lysine methyltransferase SETD1A, which specifically methylates histone 3 lysine 4 (H3K4), is involved in tumor growth and metastasis, and its ...
Jugang Wu, Hongjuan Chai, Haiyan Shan, Chunpeng Pan, Xin Xu, Wenpei Dong, Jiwei Yu, Yan Gu   +7 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Analysis of the role of mutations in the KMT2D histone lysine methyltransferase in bladder cancer

FEBS Open Bio, 2019
Histone lysine methyltransferases (HMT) comprise a subclass of epigenetic regulators; dysregulation of these enzymes affects gene expression, which may lead to tumorigenesis.
Beichen Ding, Libin Yan, Yucong Zhang, Zhize Wang, Yangjun Zhang, Ding Xia, Zhangqun Ye, Hua Xu   +7 more
doaj   +1 more source

Thermal stress induces upregulation of l(2)efl in eggs of Apis mellifera jemenitica and Apis mellifera carnica (Hymenoptera, Apidae) [PDF]

Bulletin of Insectology
Apis mellifera subspecies exhibit strong adaptation to their respective natural habitats; however, they display varying responses to thermal stress. In the present study, we examined the expression of lethal(2)-essential-for-life-like (l(2)efl) gene ...
Yehya Alattal, Ahmad Alghamdi
doaj   +3 more sources

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source