Results 61 to 70 of about 257,789 (305)

Interactions between core histone marks and DNA methyltransferases predict DNA methylation patterns observed in human cells and tissues

Epigenetics, 2020
DNA methylation and histone modifications are two major epigenetic marks in mammalian cells. Previous studies have revealed that these two mechanisms interact although a quantitative model of these is still lacking in mammalian cells.
Kai Fu, Giancarlo Bonora, Matteo Pellegrini   +2 more
doaj   +1 more source

DNA methylation and regulatory elements during chicken germline stem cell differentiation [PDF]

, 2018
Funding for Open Access provided by the UMD Libraries' Open Access Publishing Fund.The production of germ cells in vitro would open important new avenues for stem biology and human medicine, but the mechanisms of germ cell differentiation are not well ...
Cai, Wentao, Edwards, John, He, Yanghua, Lei, Jinzhi, Li, Bichun, Nie, Qing, Song, Jiuzhou, Zhao, Keji, Zuo, Qisheng   +8 more
core   +2 more sources

SnapShot: Lysine Methylation beyond Histones

Molecular Cell, 2017
Lysine methylation is a prevalent post-translational modification (PTM) used by the cell to reversibly regulate protein function. Although it has been extensively studied in the context of histones and the associated chromatin, the remaining methyllysine proteome remains largely unexplored.
Biggar, Kyle K., Wang, Zhentian, Li, Shawn S.C.   +2 more
openaire   +4 more sources

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Reversible Regulation of Promoter and Enhancer Histone Landscape by DNA Methylation in Mouse Embryonic Stem Cells

Cell Reports, 2016
DNA methylation is one of a number of modes of epigenetic gene regulation. Here, we profile the DNA methylome, transcriptome, and global occupancy of histone modifications (H3K4me1, H3K4me3, H3K27me3, and H3K27ac) in a series of mouse embryonic stem ...
Andrew D. King, Kevin Huang, Liudmilla Rubbi, Shuo Liu, Cun-Yu Wang, Yinsheng Wang, Matteo Pellegrini, Guoping Fan   +7 more
doaj   +1 more source

DNA methylation dynamics in aging: How far are we from understanding the mechanisms? [PDF]

, 2018
DNA methylation is currently the most promising molecular marker for monitoring aging and predicting life expectancy. However, the mechanisms underlying age-related DNA methylation changes remain mostly undiscovered.Here we discuss the current knowledge ...
Caiafa, Paola, Ciccarone, Fabio, Tagliatesta, Stefano, Zampieri, Michele   +3 more
core   +1 more source

Environmental Exposures during Puberty: Window of Breast Cancer Risk and Epigenetic Damage. [PDF]

, 2020
During puberty, a woman's breasts are vulnerable to environmental damage ("window of vulnerability"). Early exposure to environmental carcinogens, endocrine disruptors, and unhealthy foods (refined sugar, processed fats, food additives) are hypothesized ...
Aljaber, Dana, Au, Dawn, Benmarhnia, Tarik, Cardiff, Robert D, Chavez, Tanya, Dietze, Eric C, Doan, Stacey, Jankowska, Marta M, Jones, Veronica, McCune, Jeannine S, Natarajan, Rama, Nunez, Alan, Resto, Cristal, Sanchez, Angelica, Seewaldt, Victoria L, Serrano, Mayra, Sistrunk, Christopher, Thai, Christine, Tomsic, Jerneja, Yang, Jiue-An   +19 more
core   +1 more source

Molecular Coupling of DNA Methylation and Histone Methylation [PDF]

Epigenomics, 2010
The combinatorial pattern of DNA and histone modifications constitutes an epigenetic 'code' that shapes gene-expression patterns by enabling or restricting the transcriptional potential of genomic domains. DNA methylation is associated with histone modifications, particularly the absence of histone H3 lysine 4 methylation (H3K4me0) and the presence of ...
Hideharu, Hashimoto, Paula M, Vertino, Xiaodong, Cheng   +2 more
openaire   +2 more sources

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Retinoblastoma makes its mark on imprinting in plants [PDF]

, 2008
Genomic imprinting results in the preferential expression of alleles from either the maternal or paternal chromosomes. This epigenetic process occurs in embryonic and extra-embryonic (placental) tissues of mammals, but only in the extra-embryonic ...
Liliana M Costa, José F Gutierrez-Marcos, Wolf, Youngson, Spillane, Kermicle, Feil, Delaval, Bourc&apos, Schoenherr, Mager, Lewis, Gutierrez-Marcos, Kinoshita, Jullien, Choi, Morales-Ruiz, Reik, McCabe, Jung, Ebel, Hennig, Guitton, Ingouff, Jullien, Kimura, Rossi, Wu, Mathieu, Wu   +29 more
core   +2 more sources