Results 61 to 70 of about 166,151 (260)

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

KSHV encoded ORF59 modulates histone arginine methylation of the viral genome to promote viral reactivation. [PDF]

PLoS Pathogens, 2017
Kaposi's sarcoma associated herpesvirus (KSHV) persists in a highly-ordered chromatin structure inside latently infected cells with the majority of the viral genome having repressive marks. However, upon reactivation the viral chromatin landscape changes
Roxanne C Strahan, Maria McDowell-Sargent, Timsy Uppal, Pravinkumar Purushothaman, Subhash C Verma   +4 more
doaj   +1 more source

Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus

FEBS Open Bio, EarlyView.
BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima, Gustavo Narvaes Guimarães, Emilyane de Oliveira Santana Amaral, Bianca Caroline Figueiredo Bianco, Manuel Jara‐Espejo, Sérgio Roberto Peres Line, Ana Paula de Souza, Aline Cristiane Planello   +7 more
wiley   +1 more source

Genome-wide gene expression profiling to investigate molecular phenotypes of Arabidopsis mutants deprived in distinct histone methyltransferases and demethylases

Genomics Data, 2015
Histone lysine (K) methylation is a type of epigenetic modification involved in regulation of DNA-based processes, including transcription, replication and repair.
Wei Zhao, Sarfraz Shafiq, Alexandre Berr, Wen-Hui Shen   +3 more
doaj   +1 more source

Mechanism of DNA Methylation-Directed Histone Methylation by KRYPTONITE [PDF]

Molecular Cell, 2014
In Arabidopsis, CHG DNA methylation is controlled by the H3K9 methylation mark through a self-reinforcing loop between DNA methyltransferase CHROMOMETHYLASE3 (CMT3) and H3K9 histone methyltransferase KRYPTONITE/SUVH4 (KYP). We report on the structure of KYP in complex with methylated DNA, substrate H3 peptide, and cofactor SAH, thereby defining the ...
Du, Jiamu, Johnson, Lianna M, Groth, Martin, Feng, Suhua, Hale, Christopher J, Li, Sisi, Vashisht, Ajay A, Gallego-Bartolome, Javier, Wohlschlegel, James A, Patel, Dinshaw J, Jacobsen, Steven E   +10 more
openaire   +4 more sources

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Mutations disrupting histone methylation have different effects on replication timing in S. pombe centromere. [PDF]

PLoS ONE, 2013
The fission yeast pericentromere comprises repetitive sequence elements packaged into heterchromatin marked by histone H3K9 methylation and Swi6 binding. Transient disruption of Swi6 during S phase allows a period of RNA synthesis which programs the RNAi
Pao-Chen Li, Marc D Green, Susan L Forsburg   +2 more
doaj   +1 more source

Histone Methylation Regulates Memory Formation [PDF]

The Journal of Neuroscience, 2010
It has been established that regulation of chromatin structure through post-translational modification of histone proteins, primarily histone H3 phosphorylation and acetylation, is an important early step in the induction of synaptic plasticity and formation of long-term memory.
Swati, Gupta, Se Y, Kim, Sonja, Artis, David L, Molfese, Armin, Schumacher, J David, Sweatt, Richard E, Paylor, Farah D, Lubin   +7 more
openaire   +2 more sources

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

The roles of histone methylation in the regulation of abiotic stress responses in plants

Plant Stress
Abiotic stress greatly threaten plants’ growth and ultimately impact crop productivity. Plants have evolved sophisticated regulatory mechanisms to cope with stressful conditions, including undergoing physiological changes through genetic and epigenetic ...
Lei Shi, Xiaoyun Cui, Yuan Shen
doaj   +1 more source