Results 11 to 20 of about 29,619 (246)

Disruption of Methionine Metabolism in Drosophila melanogaster Impacts Histone Methylation and Results in Loss of Viability

G3: Genes, Genomes, Genetics, 2016
Histone methylation levels, which are determined by the action of both histone demethylases and methyltransferases, impact multiple biological processes by affecting gene expression activity.
Mengying Liu, Valerie L. Barnes, Lori A. Pile   +2 more
doaj   +1 more source

Mechanisms of carcinogenic activity triggered by lysine-specific demethylase 1A

Frontiers in Pharmacology, 2022
Epigenetics has emerged as a prime focus area in the field of cancer research. Lysine-specific demethylase 1A (LSD1), the first discovered histone demethylase, is mainly responsible for catalysing demethylation of histone 3 lysine 4 (H3K4) and H3K9 to ...
Chao Yang, Dan Li, Shaohong Zang, Lei Zhang, Zhangfeng Zhong, Yingtang Zhou   +5 more
doaj   +1 more source

Histone Lysine Demethylase Inhibitors [PDF]

Cold Spring Harbor Perspectives in Medicine, 2016
The dynamic regulation of covalent modifications to histones is essential for maintaining genomic integrity and cell identity and is often compromised in cancer. Aberrant expression of histone lysine demethylases has been documented in many types of blood and solid tumors, and thus demethylases represent promising therapeutic targets.
Ashwini, Jambhekar, Jamie N, Anastas, Yang, Shi   +2 more
openaire   +2 more sources

LSD1: Expanding Functions in Stem Cells and Differentiation

Cells, 2021
Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSC) provide a powerful model system to uncover fundamental mechanisms that control cellular identity during mammalian development. Histone methylation governs gene expression programs that
Carlos Martinez-Gamero, Sandhya Malla, Francesca Aguilo   +2 more
doaj   +1 more source

Evolutionary history of histone demethylase families: distinct evolutionary patterns suggest functional divergence

BMC Evolutionary Biology, 2008
Background Histone methylation can dramatically affect chromatin structure and gene expression and was considered irreversible until recent discoveries of two families of histone demethylases, the KDM1 (previously LSD1) and JmjC domain-containing ...
Zhou Xiaofan, Ma Hong
doaj   +1 more source

Pathophysiological Response to Hypoxia — From the Molecular Mechanisms of Malady to Drug Discovery: Epigenetic Regulation of the Hypoxic Response via Hypoxia-Inducible Factor and Histone Modifying Enzymes

Journal of Pharmacological Sciences, 2011
The hypoxia response regulated primarily by hypoxia-inducible factor (HIF) influences metabolism, cell survival, and angiogenesis to maintain biological homeostasis.
Imari Mimura, Tetsuhiro Tanaka, Youichiro Wada, Tatsuhiko Kodama, Masaomi Nangaku   +4 more
doaj   +1 more source

JMJD1B Demethylates H4R3me2s and H3K9me2 to Facilitate Gene Expression for Development of Hematopoietic Stem and Progenitor Cells

Cell Reports, 2018
Summary: The arginine methylation status of histones dynamically changes during many cellular processes, including hematopoietic stem/progenitor cell (HSPC) development.
Sihui Li, Shafat Ali, Xiaotao Duan, Songbai Liu, Juan Du, Changwei Liu, Huifang Dai, Mian Zhou, Lina Zhou, Lu Yang, Peiguo Chu, Ling Li, Ravi Bhatia, Dustin E. Schones, Xiwei Wu, Hong Xu, Yuejin Hua, Zhigang Guo, Yanzhong Yang, Li Zheng, Binghui Shen   +20 more
doaj   +1 more source

Current Perspectives on Histone Demethylases [PDF]

Acta Biochimica et Biophysica Sinica, 2007
The posttranslational modification of histones plays an important role in chromatin regulation. Histone methylation influences constitutive heterochromatin, genomic imprinting, X-chromosome inactivation and gene transcription. Histone demethylase catalyzes the removal of methyl groups on lysine or arginine residues of histones.
Xiaoqing, Tian, Jingyuan, Fang
openaire   +2 more sources

Evidence of a Demethylase-Independent Role for the H3K4-Specific Histone Demethylases in Aspergillus nidulans and Fusarium graminearum Secondary Metabolism

Frontiers in Microbiology, 2019
Fungi produce a plethora of secondary metabolites (SMs) involved in cellular protection, defense, and signaling. Like other metabolic processes, transcription of SM biosynthesis genes is tightly regulated to prevent an unnecessary use of resources. Genes
Simone Bachleitner, Jens Laurids Sørensen, Agnieszka Gacek-Matthews, Michael Sulyok, Lena Studt, Joseph Strauss   +5 more
doaj   +1 more source

Histone Demethylases in Colon Cancer [PDF]

Current Colorectal Cancer Reports, 2014
Cell growth and proliferation are controlled through different posttranslational modifications including demethylation, a process regulated by regulated by the demethylase enzymes. This review focuses on our current understanding of functional and therapeutic potentials of histone demethylases in colon cancer.
Santanu, Paul, Satish, Ramalingam, Dharmalingam, Subramaniam, Joaquina, Baranda, Shrikant, Anant, Animesh, Dhar   +5 more
openaire   +2 more sources