Results 31 to 40 of about 22,032 (210)

Histone Demethylase AMX-1 Regulates Fertility in a p53/CEP-1 Dependent Manner

Frontiers in Genetics, 2022
Histone methylation shapes the epigenetic configuration and adjusts multiple fundamental nuclear processes, including transcription, cell cycle control and DNA repair.
Xiaojing Ren, Sisi Tian, Qinghao Meng, Hyun-Min Kim, Hyun-Min Kim   +4 more
doaj   +1 more source

KDM4C Activity Modulates Cell Proliferation and Chromosome Segregation in Triple-Negative Breast Cancer

Breast Cancer: Basic and Clinical Research, 2016
The Jumonji-containing domain protein, KDM4C, is a histone demethylase associated with the development of several forms of human cancer. However, its specific function in the viability of tumoral lineages is yet to be determined.
Jeison Garcia, Fernando Lizcano
doaj   +1 more source

MoJMJ1, Encoding a Histone Demethylase Containing JmjC Domain, Is Required for Pathogenic Development of the Rice Blast Fungus, Magnaporthe oryzae

The Plant Pathology Journal, 2017
Histone methylation plays important roles in regulating chromatin dynamics and transcription in eukaryotes. Implication of histone modifications in fungal pathogenesis is, however, beginning to emerge.
Aram Huh, Akanksha Dubey, Seongbeom Kim, Junhyun Jeon, Yong-Hwan Lee   +4 more
doaj   +1 more source

Histone demethylase JMJD1C is phosphorylated by mTOR to activate de novo lipogenesis. [PDF]

, 2020
Fatty acid and triglyceride synthesis increases greatly in response to feeding and insulin. This lipogenic induction involves coordinate transcriptional activation of various enzymes in lipogenic pathway, including fatty acid synthase and glycerol-3 ...
Choi, Yoon, Nguyen, Hai, SUL, Hei Sook, Viscarra, Jose, Wang, Yuhui   +4 more
core  

Epigenetics in ovarian cancer: premise, properties, and perspectives. [PDF]

, 2018
Malignant ovarian tumors bear the highest mortality rate among all gynecological cancers. Both late tumor diagnosis and tolerance to available chemical therapy increase patient mortality.
Huang, Shuang, Lau, Bonnie, Lau, Wayne Bond, Tang, Kexin, Wang, Hongjing, Wang, Wei, Wang, Xin, Wei, Yuquan, Xu, Lian, Yang, Qilian, Yang, Yuqing, Yang, Zhengnan, Yi, Tao, Zhao, Linjie, Zhao, Xia, Zhou, Nianxin, Zhou, Shengtao   +16 more
core   +2 more sources

Discovery and structural studies of histone demethylases

Frontiers in Epigenetics and Epigenomics
The discovery and structural elucidation of histone demethylases represent a groundbreaking advancement in the field of epigenetics. Histone methylation, a critical chromatin modification, was long regarded as irreversible until the identification of ...
Longfei Peng, Xinze Li, Hao Yang, Haonan Chen, Yue Yang, Shunfeng Peng   +5 more
doaj   +1 more source

Prohexadione, a plant growth regulator, inhibits histone lysine demethylases and modulates epigenetics

Toxicology Reports, 2014
Background: Epigenetic modifications, particularly DNA methylation and posttranslational histone modifications regulate heritable changes in transcription without changes in the DNA sequence.
Divya Teja Vavilala, Sujatha Reddy, Sachchidanand, Swami Prakash, V.K. Chaithanya Ponnaluri, Arvind Kumar, Mridul Mukherji   +6 more
doaj   +1 more source

Pharmacological modulation of histone demethylase activity by a small molecule isolated from subcritical water extracts of Sasa senanensis leaves prolongs the lifespan of Drosophila melanogaster

BMC Complementary and Alternative Medicine, 2012
Background Extracts of Sasa senanensis Rehder are used in traditional Japanese medicine; however, little is known about the underlying mechanisms of their potential health benefits. Methods S. senanensis leaves were extracted with subcritical water.
Nakagawa-Yagi Yuzo, Sato Yukiko, Matsumoto Emi, Nakatsuka Shin-ichi, Sakaki Tsuyoshi, Muramatsu Yukiko, Hara Takaaki, Aigaki Toshiro   +7 more
doaj   +1 more source

Mutations in the PKM2 exon-10 region are associated with reduced allostery and increased nuclear translocation. [PDF]

, 2019
PKM2 is a key metabolic enzyme central to glucose metabolism and energy expenditure. Multiple stimuli regulate PKM2's activity through allosteric modulation and post-translational modifications.
Chen, Tsan-Jan, Cheng, Hsin-Hung, Hsu, Sheng-Chieh, Kung, Hsing-Jien, Liu, Jai-Shin, Liu, Ying-Yuan, Lu, Chien-Hung, Wang, Hung-Jung, Wang, Wen-Ching, Wu, Jing-Wen, Wu, Meng-Chen, Wu, Yu-Fang   +11 more
core   +3 more sources

The histone demethylase activity of Rph1 is not essential for its role in the transcriptional response to nutrient signaling.

PLoS ONE, 2014
Rph1 and Gis1 are two related yeast zinc finger proteins that function as downstream effectors in the Ras/PKA, TOR and Sch9 nutrient signaling pathways.
Niklas Nordberg, Ida Olsson, Mattias Carlsson, Guo-Zhen Hu, Jakub Orzechowski Westholm, Hans Ronne   +5 more
doaj   +1 more source