Results 21 to 30 of about 29,619 (246)
HP1a targets the Drosophila KDM4A demethylase to a subset of heterochromatic genes to regulate H3K36me3 levels. [PDF]
PLoS ONE, 2012 The KDM4 subfamily of JmjC domain-containing demethylases mediates demethylation of histone H3K36me3/me2 and H3K9me3/me2. Several studies have shown that human and yeast KDM4 proteins bind to specific gene promoters and regulate gene expression. However,
Chia-Hui Lin +3 more
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In Vitro Histone Demethylase Assay [PDF]
Cold Spring Harbor Protocols, 2010 INTRODUCTIONPost-translational modifications of histones play an important role in regulating chromatin dynamics and function. One of the modifications, methylation, occurs on both lysine and arginine residues, and methylation status defines the epigenetic program of a cell by determining chromatin structure and thereby regulating DNA-dependent ...
Yu-ichi, Tsukada, Keiichi I, Nakayama
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PLoS ONE, 2013 Histone modifications play an important role in chromatin organization and gene regulation, and their interpretation is referred to as epigenetic control. The methylation levels of several lysine residues in histone tails are tightly controlled, and JmjC
Michael Brauchle +14 more
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The dual functions of KDM7A in HBV replication and immune microenvironment
Microbiology Spectrum, 2023 KDM7A (lysine demethylase 7A, also known as JHDM1D) is a histone demethylase, it is mainly involved in the intracellular post-translational modifications process.
Di Yang +11 more
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Histone demethylation maintains Prdm14 and Tsix expression and represses xIst in embryonic stem cells. [PDF]
PLoS ONE, 2015 Epigenetic reprogramming is exemplified by the remarkable changes observed in cellular differentiation and X-chromosome inactivation (XCI) in mammalian female cells.
Yasunao F Kamikawa, Mary E Donohoe
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Functional Characterization of the Lysine-Specific Histone Demethylases Family in Soybean
Plants, 2022 Histone modifications, such as methylation and demethylation, have crucial roles in regulating chromatin structure and gene expression. Lysine-specific histone demethylases (LSDs) belong to the amine oxidase family, which is an important family of ...
Mengshi Liu +7 more
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Human Histone Demethylase LSD1 Reads the Histone Code [PDF]
Journal of Biological Chemistry, 2005 Human histone demethylase LSD1 is a flavin-dependent amine oxidase that catalyzes the specific removal of methyl groups from mono- and dimethylated Lys4 of histone H3. The N-terminal tail of H3 is subject to various covalent modifications, and a fundamental question in LSD1 biology is how these epigenetic marks affect the demethylase activity.
F. Forneris +4 more
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Breast Cancer: Basic and Clinical Research, 2016 The Jumonji-containing domain protein, KDM4C, is a histone demethylase associated with the development of several forms of human cancer. However, its specific function in the viability of tumoral lineages is yet to be determined.
Jeison Garcia, Fernando Lizcano
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The Plant Pathology Journal, 2017 Histone methylation plays important roles in regulating chromatin dynamics and transcription in eukaryotes. Implication of histone modifications in fungal pathogenesis is, however, beginning to emerge.
Aram Huh +4 more
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Histone Demethylase AMX-1 Regulates Fertility in a p53/CEP-1 Dependent Manner
Frontiers in Genetics, 2022 Histone methylation shapes the epigenetic configuration and adjusts multiple fundamental nuclear processes, including transcription, cell cycle control and DNA repair.
Xiaojing Ren +4 more
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