Results 21 to 30 of about 22,032 (210)

JMJD1B Demethylates H4R3me2s and H3K9me2 to Facilitate Gene Expression for Development of Hematopoietic Stem and Progenitor Cells

Cell Reports, 2018
Summary: The arginine methylation status of histones dynamically changes during many cellular processes, including hematopoietic stem/progenitor cell (HSPC) development.
Sihui Li, Shafat Ali, Xiaotao Duan, Songbai Liu, Juan Du, Changwei Liu, Huifang Dai, Mian Zhou, Lina Zhou, Lu Yang, Peiguo Chu, Ling Li, Ravi Bhatia, Dustin E. Schones, Xiwei Wu, Hong Xu, Yuejin Hua, Zhigang Guo, Yanzhong Yang, Li Zheng, Binghui Shen   +20 more
doaj   +1 more source

Evidence of a Demethylase-Independent Role for the H3K4-Specific Histone Demethylases in Aspergillus nidulans and Fusarium graminearum Secondary Metabolism

Frontiers in Microbiology, 2019
Fungi produce a plethora of secondary metabolites (SMs) involved in cellular protection, defense, and signaling. Like other metabolic processes, transcription of SM biosynthesis genes is tightly regulated to prevent an unnecessary use of resources. Genes
Simone Bachleitner, Jens Laurids Sørensen, Agnieszka Gacek-Matthews, Michael Sulyok, Lena Studt, Joseph Strauss   +5 more
doaj   +1 more source

HP1a targets the Drosophila KDM4A demethylase to a subset of heterochromatic genes to regulate H3K36me3 levels. [PDF]

PLoS ONE, 2012
The KDM4 subfamily of JmjC domain-containing demethylases mediates demethylation of histone H3K36me3/me2 and H3K9me3/me2. Several studies have shown that human and yeast KDM4 proteins bind to specific gene promoters and regulate gene expression. However,
Chia-Hui Lin, Ariel Paulson, Susan M Abmayr, Jerry L Workman   +3 more
doaj   +1 more source

New insights into the epigenetic control of satellite cells [PDF]

, 2015
Epigenetics finely tunes gene expression at a functional level without modifying the DNA sequence, thereby contributing to the complexity of genomic regulation.
Adamo, Sergio, Marroncelli, Nicoletta, Moresi, Viviana   +2 more
core   +1 more source

LSD1 is essential for oocyte meiotic progression by regulating CDC25B expression in mice [PDF]

, 2015
Mammalian oocytes are arrested at prophase I until puberty when hormonal signals induce the resumption of meiosis I and progression to meiosis II.
Chen, T, Kerenyi, MA, Kim, J, Lin, K, Lu, Y, Orkin, SH, Shen, J, Singh, AK, Takata, Y   +8 more
core   +1 more source

The dual functions of KDM7A in HBV replication and immune microenvironment

Microbiology Spectrum, 2023
KDM7A (lysine demethylase 7A, also known as JHDM1D) is a histone demethylase, it is mainly involved in the intracellular post-translational modifications process.
Di Yang, Renyun Tian, Rilin Deng, Binbin Xue, Shun Liu, Luoling Wang, Huiyi Li, Qian Liu, Mengyu Wan, Songqing Tang, Xiaohong Wang, Haizhen Zhu   +11 more
doaj   +1 more source

Methylated DNMT1 and E2F1 Are Targeted for Proteolysis by L3MBTL3 and CRL4DCAF5 Ubiquitin Ligase [PDF]

, 2018
Many non-histone proteins are lysine methylated and a novel function of this modification is to trigger the proteolysis of methylated proteins. Here, we report that the methylated lysine 142 of DNMT1, a major DNA methyltransferase that preserves ...
Alejo, Salvador, Hoang, Nam, Leng, Feng, Lu, Fei, Sun, Hong, Yu, Jiekai, Zhang, Chunxiao, Zhang, Hui   +7 more
core   +3 more sources

Protein complex interactor analysis and differential activity of KDM3 subfamily members towards H3K9 methylation.

PLoS ONE, 2013
Histone modifications play an important role in chromatin organization and gene regulation, and their interpretation is referred to as epigenetic control. The methylation levels of several lysine residues in histone tails are tightly controlled, and JmjC
Michael Brauchle, Zhiping Yao, Rishi Arora, Sachin Thigale, Ieuan Clay, Bruno Inverardi, Joy Fletcher, Paul Taslimi, Michael G Acker, Bertran Gerrits, Johannes Voshol, Andreas Bauer, Dirk Schübeler, Tewis Bouwmeester, Heinz Ruffner   +14 more
doaj   +1 more source

Histone demethylation maintains Prdm14 and Tsix expression and represses xIst in embryonic stem cells. [PDF]

PLoS ONE, 2015
Epigenetic reprogramming is exemplified by the remarkable changes observed in cellular differentiation and X-chromosome inactivation (XCI) in mammalian female cells.
Yasunao F Kamikawa, Mary E Donohoe
doaj   +1 more source

Functional Characterization of the Lysine-Specific Histone Demethylases Family in Soybean

Plants, 2022
Histone modifications, such as methylation and demethylation, have crucial roles in regulating chromatin structure and gene expression. Lysine-specific histone demethylases (LSDs) belong to the amine oxidase family, which is an important family of ...
Mengshi Liu, Jiacan Jiang, Yapeng Han, Mengying Shi, Xianli Li, Yingxiang Wang, Zhicheng Dong, Cunyi Yang   +7 more
doaj   +1 more source