Results 91 to 100 of about 6,610 (186)

Targeting Endothelial KDM5A to Attenuate Aging and Ameliorate Age‐Associated Metabolic Abnormalities

Advanced Science, Volume 13, Issue 6, 30 January 2026.
This study identifies endothelial KDM5A as a key regulator of aging. KDM5A deficiency accelerates aging by enhancing H3K4me3‐mediated FABP4 expression, disrupting fatty acid metabolism, and promoting multi‐organ senescence. KDM5A restoration or FABP4 inhibition reverses these adverse effects and extends lifespan, positioning the KDM5A/FABP4 axis as a ...
Rifeng Gao, Lifeng Liang, Ling Yang, Chunyu Lyu, Yang Lyu, Weijun Yang, Jiaran Shi, Wei Wei, Jiahui Cheng, Xiaolei Sun, Xian Zhu, Chao Chen, Xiaoting Xu, Jianchuang Qi, Wenli Li, Yizhe Zhang, Xiao Zhang, Yan Zhou, Aiqiang Dong, Juntao Chen, Bo Li, Kun Yang   +21 more
wiley   +1 more source

Mina53 demethylates histone H4 arginine 3 asymmetric dimethylation to regulate neural stem/progenitor cell identity

Nature Communications
Arginine methylation of histones plays a critical role in regulating gene expression. The writers (methyltransferases) and readers of methylarginine marks are well-known, but the erasers–arginine demethylases–remain mysterious.
Lixiao Zhou, Xingsen Zhao, Jie Sun, Kun Zou, Xiaoli Huang, Liyang Yu, Mingxuan Wu, Yong Wang, Xuekun Li, Wen Yi   +9 more
doaj   +1 more source

Balancing of Histone H3K4 Methylation States by the Kdm5c/SMCX Histone Demethylase Modulates Promoter and Enhancer Function [PDF]

, 2013
The functional organization of eukaryotic genomes correlates with specific patterns of histone methylations. Regulatory regions in genomes such as enhancers and promoters differ in their extent of methylation of histone H3 at lysine-4 (H3K4), but it is ...
Graaf, P. (Petra) de, Groot Koerkamp, M.J.A. (Marianne), Grosveld, F.G. (Frank), Holstege, F.C.P. (Frank), IJcken, W.F.J. (Wilfred) van, Kaufmann, K. (Kerstin), Leenen, D. (Dik) van, Muiño, J.M. (Jose), Outchkourov, N.S. (Nikolay), Timmers, H.T.M. (Marc)   +9 more
core   +1 more source

Lysine demethylase 4A is a centrosome‐associated protein required for centrosome integrity and genomic stability

The FEBS Journal, Volume 293, Issue 2, Page 396-417, January 2026.
KDM4A, a chromatin eraser, localizes to the centrosomes. Its demethylase activity is essential for maintaining centrosome number and integrity, independent of gene expression changes. Loss of KDM4A leads to centrosome amplification, pseudo‐bipolar spindle formation, and chromosome segregation errors, including micronuclei and chromatin bridges.
Pratim Chowdhury, Xiaoli Wang, Richard I. Han, Manga Motrapu, Ashley G. Boice, Yuya Nakatani, Sofia Vargas‐Hernandez, Julia F. Love, Claude Chew, Sandra L. Grimm, Dereck Mezquita, Frank M. Mason, Elisabeth D. Martinez, Cristian Coarfa, Cheryl L. Walker, Anna‐Karin Gustavsson, Ruhee Dere   +16 more
wiley   +1 more source

Cellular analysis of the action of epigenetics drugs and probes [PDF]

, 2017
Small molecule drugs and probes are important tools in drug discovery, pharmacology, and cell biology. This is of course also true for epigenetic inhibitors.
A. Ganesan, Edwards AM, Fides Zenk, Gajer (née Wagner) J, Glaser KB, Glaser KB, Jung M, Lynch JT, Maeda T, Manfred Jung, Mirjam Hau, Nicola Iovino, van Lint C   +12 more
core   +1 more source

Genome-wide identification and expression analysis of JmjC domain-containing family in Vitis vinifera L.

BMC Genomics
Background In eukaryotes, histone methylation is essential for controlling chromatin structure, gene transcription, and related chromatin processes. Jumonji C (JmjC) domain-containing demethylases (JMJs) regulate histone methylation levels.
Mengqi Wang, Jie Wang, Wangsheng Zhu, Xin Sun   +3 more
doaj   +1 more source

The histone demethylase UTX regulates the lineage-specific epigenetic program of invariant natural killer T cells [PDF]

, 2018
Invariant natural killer T cells (iNKT cells) are innate-like lymphocytes that protect against infection, autoimmune disease and cancer. However, little is known about the epigenetic regulation of iNKT cell development.
Barnitz, R Anthony, Beyaz, Semir, Das, Partha P, Dogum, Rizkullah, Haining, W Nicholas, Herault, Aurelie, Hu, Yu,M.C.P.Massachusetts Institute of Technology., Huang, Jialiang, Kerenyi, Marc A, Kim, Ji Hyung, Orkin, Stuart H, Passegue, Emmanuelle, Pinello, Luca, Winau, Florian, Xifaras, Michael, Yilmaz, Omer, Yuan, Guo-Cheng   +16 more
core   +1 more source

Demystifying the Role of Histone Demethylases in Colorectal Cancer: Mechanisms and Therapeutic Opportunities

Current Issues in Molecular Biology
Histone demethylases (HDMs) play a pivotal role in colorectal cancer (CRC) progression through dynamic epigenetic regulation. This review summarizes the role and therapeutic potential of HDM in CRC.
Yuanbin Liu, Min Huang, Xia Tian, Xiaodong Huang   +3 more
doaj   +1 more source

Integrative genomic and transcriptomic analysis for pinpointing recurrent alterations of plant homeodomain genes and their clinical significance in breast cancer [PDF]

, 2016
A wide range of the epigenetic effectors that regulate chromatin modification, gene expression, genomic stability, and DNA repair contain structurally conserved domains called plant homeodomain (PHD) fingers. Alternations of several PHD finger-containing
Chu, Xiaofang, Jiang, Yuanyuan, Liu, Lanxin, Shan, Wenqi, Yang, Zeng-Quan, Yang, Zhe, Yu, Huimei   +6 more
core   +2 more sources

A Targeted RNA Interference Screen Reveals Novel Epigenetic Factors That Regulate Herpesviral Gene Expression [PDF]

, 2013
Herpes simplex virus (HSV) utilizes and subverts host chromatin mechanisms to express its lytic gene products in mammalian cells. The host cell attempts to silence the incoming viral genome by epigenetic mechanisms, but the viral VP16 and ICP0 proteins ...
Bagul, Mukta, Bathe, Mark, Bryant, Kevin F., Knipe, David M., Mazumder, Aprotim, Nieland, Thomas J. F., Oh, Hyung Suk, Root, David E.   +7 more
core   +2 more sources