Results 81 to 90 of about 6,610 (186)

Multifaceted roles of BBX transcription factors: impacts on key agronomical traits and environmental resilience

New Phytologist, Volume 250, Issue 2, Page 762-787, April 2026.
Summary B‐box (BBX) proteins were initially characterized as transcription factors connecting light signaling to the regulation of flowering time and seedling photomorphogenesis. However, over the last decade, increasing evidence has shown that they integrate light and hormone signaling, modulating multiple physiological processes during plant life. In
Bruno Silvestre Lira, Juliene Moreira, Luciano Freschi, Magdalena Rossi   +3 more
wiley   +1 more source

Runt-Related Transcription Factor 2 Induction During Differentiation of Wharton's Jelly Mesenchymal Stem Cells to Osteoblasts Is Regulated by Jumonji AT-Rich Interactive Domain 1B Histone Demethylase [PDF]

, 2017
Indexación: ScopusNovel bone regeneration approaches aim to obtain immature osteoblasts from somatic stem cells. Umbilical cord Wharton's jelly mesenchymal stem cells (WJ-MSCs) are an ideal source for cell therapy. Hence, the study of mechanisms involved
Amini, Baksh, Banerjee, Brydone, Burchell, Canha-Gouveia, Caplan, Carbonare, Cellot, Cho, Corotchi, Damme, Dey, Dignani, Dominici, Dull, Edwards, Fong, Frausin, Gauthaman, Geraerts, Grandy, Hassan, Hu, Huang, Hubble, Hung, Ji, Joerger-Messerli, Kalaszczynska, Karsenty, Kidder, Kim, Komori, Langenbach, Lee, Lee, Lee, Lian, Liu, Liu, Marolt, Marupanthorn, Maruyama, Mosna, Nekanti, Pittenger, Prieto, Reppel, Rocca, Rojas, Ryoo, Sarugaser, Sayegh, Schmitz, Sepulveda, Shibuya, Si, Soutoglou, Stanford, Stein, Tumber, Venugopal, Wang, Wang, Wang, Xie, Zhao   +67 more
core   +2 more sources

The Role of One‐Carbon Metabolism in Cancer and Its Therapeutic Significance

MedComm – Oncology, Volume 5, Issue 1, March 2026.
One‐Carbon metabolism in T‐cell activation and tumor competition. T‐cell activation shifts metabolic pathways, promoting anabolic metabolism and bioenergetic capacity. One‐carbon metabolism plays a crucial role in histone and DNA methylation in activated T cells.
Yuting Jiang, Guoliang Zhou, Qian Zhang, Shengtao Zhou   +3 more
wiley   +1 more source

Finding balance: the dynamic interplay between H3K27me3 writers and erasers in regulating environmental plasticity and memory

New Phytologist, Volume 249, Issue 5, Page 2241-2250, March 2026.
Summary Subject to an ever‐changing world, plants must respond to harmful conditions and environmental fluctuations. Their evolutionary success can be attributed to their plasticity in both perceiving and integrating these variations to facilitate adaptation.
Rory Osborne
wiley   +1 more source

Epigenetic mechanism of abiotic stress responses in plants

Horticulture Advances
Abiotic stress severely restricts plant growth, necessitating swift and, at times, heritable reprogramming of gene expression. To regulate chromatin states and fine-tune stress-responsive pathways, plants rely on four key epigenetic mechanisms: DNA ...
Abdullah Zaid, Anand Singh, Kamal Uddin
doaj   +1 more source

Proliferating cell nuclear antigen is required for loading of the SMCX/KMD5C histone demethylase onto chromatin [PDF]

, 2011
UNLABELLED: ABSTRACT: BACKGROUND: Histone methylation is regulated by a large number of histone methyltransferases and demethylases. The recently discovered SMCX/KMD5C demethylase has been shown to remove methyl residues from lysine 4 of histone H3 (H3K4)
Johanna A Smith, Marc Diamond, Matthias Schnell, René Daniel, Zhihui Liang   +4 more
core   +2 more sources

The KDM6B/SLC10A2 Axis Suppresses MDSCs Recruitment via ERK/AP‐1 Signaling in Colorectal Cancer

Advanced Science, Volume 13, Issue 9, 13 February 2026.
In wild‐type intestinal epithelial cells, KDM6B demethylates SLC10A2 to promote its expression, after which SLC10A2 suppresses ERK phosphorylation, inhibiting AP‐1 (Fos/Jun) transcription and chemokine production. In KDM6B‐deficient intestinal epithelial cells, SLC10A2 methylation increases, and its expression decreases.
Zhibo Hu, Jing Xun, Bin Liu, Xiaolin Jiang, Yingdi Han, Huichao Yang, Qi Gao, Ruifang Gao, Aimin Zhang, Xueliang Wu, Dapeng Zhang, Dihua Li, Tian Li, Shimin Yang, Ximo Wang, Xiangyang Yu, Qi Zhang   +16 more
wiley   +1 more source

Oxidative stress and epigenetic regulation in ageing and age-related diseases [PDF]

, 2013
Recent statistics indicate that the human population is ageing rapidly. Healthy, but also diseased, elderly people are increasing. This trend is particularly evident in Western countries, where healthier living conditions and better cures are available ...
Cencioni, Chiara, Gaetano, Carlo, Mai, Antonello, Martelli, Fabio, Spallotta, Francesco, Valente, Sergio, Zeiher, Andreas Michael   +6 more
core   +2 more sources

Microbial metabolites in tumor epigenetic regulation

iMeta, Volume 5, Issue 1, February 2026.
The gut microbiome modulates tumor epigenetic regulation through bioactive metabolites derived from dietary substrates. Microbiota‐produced SCFAs, secondary BAs, one‐carbon metabolites, and tryptophan‐derived ligands regulate histone acetylation, DNA methylation, and chromatin remodeling via HDAC, DNMT, AhR, and metabolic cofactor‐dependent pathways ...
Wangzheqi Zhang, Haoling Zhang, Yan Liao, Shuya Jiang, Haolong Zhang, Chenwei Huang, Zhijing Song, Rui Zhao, Ping Lu, Xiaohong Kang, Eryan Kong, Yalin Zhu, Wei Wang, Xuesong Liu, Yisheng Chen, Zhiwen Luo, Zhaoyu Li, Di Wang, Na Xing, Yadong Guo, Jingjing Zhang, Xiaojing Wang, Wenyi Wang, Mowaffaq Adam, Bakiah Shaharuddin, Muhamad Yusri Musa, Doblin Sandai, Chenglong Zhu, Aimin Jiang, Peng Luo, Zhijie Zhao, Zui Zou   +31 more
wiley   +1 more source

Epigenetics in diagnosis, prognostic assessment and treatment of cancer:An update [PDF]

, 2014
Cancer cells contain multiple genetic and epigenetic changes. The relative specificity of many epigenetic changes for neoplastic cells has allowed the identification of diagnostic, prognostic and predictive biomarkers for a number of solid tumors and ...
Briasoulis, Evangelos, Crook, Tim, Hatzimichael, Eleftheria, Lagos, Konstantinos, Sim, Van Ren   +4 more
core   +4 more sources