Results 121 to 130 of about 53,955 (247)

H3K9 methyltransferases and demethylases control lung tumor-propagating cells and lung cancer progression

Nature Communications, 2018
Epigenetic regulators are attractive anticancer targets, but the promise of therapeutic strategies inhibiting some of these factors has not been proven in vivo or taken into account tumor cell heterogeneity.
Samuel P. Rowbotham, Samuel P. Rowbotham, Fei Li, A. Dost, A. Dost, S. M. Louie, S. M. Louie, B. P. Marsh, B. P. Marsh, P. Pessina, P. Pessina, C. Anbarasu, C. Anbarasu, C. Brainson, Stephanie J. Tuminello, A. Lieberman, S. Ryeom, T. Schlaeger, Bruce J. Aronow, H. Watanabe, Kwok-Kin Wong, Carla F. Kim, Carla F. Kim   +22 more
semanticscholar   +1 more source

A convenient research strategy for functional verification of epigenetic regulators during spermatogenesis

Asian Journal of Andrology
Spermatogenesis is a fundamental process that requires a tightly controlled epigenetic event in spermatogonial stem cells (SSCs). The mechanisms underlying the transition from SSCs to sperm are largely unknown.
Shan Li, Ying Yuan, Ke-Yu Zhang, Yi-Dan Guo, Lu-Tong Wang, Xiao-Yuan Zhang, Shu Zhang, Qi Yan, Rong Zhang, Jie Chen, Feng-Tang Yang, Jing-Rui Li   +11 more
doaj   +1 more source

Arginine demethylation is catalysed by a subset of JmjC histone lysine demethylases

Nature Communications, 2016
While the oxygen-dependent reversal of lysine Nɛ-methylation is well established, the existence of bona fide Nω-methylarginine demethylases (RDMs) is controversial.
L. Walport, Richard J. Hopkinson, R. Chowdhury, Rachel Schiller, Wei Ge, A. Kawamura, C. Schofield   +6 more
semanticscholar   +1 more source

Investigating postharvest chilling injury in tomato (Solanum lycopersicum L.) fruit using magnetic resonance imaging and 5-azacytidine, a hypomethylation agent [PDF]

, 2020
Tomato, like most species from tropical and subtropical regions, exhibits postharvest chilling injury (PCI) when stored at low temperatures. Because of its economic importance and the functional genomics tools available, we used tomato to investigate ...
Albornoz, K, Beckles, DM, Cantwell, M, Chen, B, McCarthy, M, Zhang, L   +5 more
core  

Molecular modelling and Function Prediction of hABH7, human homologue of _E. coli_ ALKB7 [PDF]

, 2011
Human homologues of ALKB protein have shown the prime role in DNA damaging drugs, used for cancer therapy. Little is known about structure and function of hABH7, one of the members of this superfamily. Therefore, in the present study we intend to predict
Ambarish Sharan Vidyarthi, Mr. Shankaracharya, Saibal Das   +2 more
core   +1 more source

JmjC histone demethylases act as chromatin oxygen sensors

Molecular & Cellular Oncology, 2019
Oxygen sensing is important in physiology but also in disease. We find that hypoxia (oxygen deficiency) triggers rapid and hypoxia-inducible factor (HIF)-independent histone methylation changes which are reversible upon reoxygenation.
M. Batie, S. Rocha
semanticscholar   +1 more source

Tricarboxylic Acid Cycle Regulation of Metabolic Program, Redox System, and Epigenetic Remodeling for Bone Health and Disease

Antioxidants
Imbalanced osteogenic cell-mediated bone gain and osteoclastic remodeling accelerates the development of osteoporosis, which is the leading risk factor of disability in the elderly.
Wei-Shiung Lian, Re-Wen Wu, Yu-Han Lin, Yu-Shan Chen, Holger Jahr, Feng-Sheng Wang   +5 more
doaj   +1 more source

Histone demethylases in autophagy and inflammation

Cell Communication and Signaling
Autophagy dysfunction is associated with changes in autophagy-related genes. Various factors are connected to autophagy, and the mechanism regulating autophagy is highly complicated. Epigenetic changes, such as aberrant expression of histone demethylase,
Yaoyao Ma, Wenting Lv, Yi Guo, Tong Yin, Yujie Bai, Ziqi Liu, Chao Chen, WenjuanYang, Jiayi Feng, Wenbin Qian, Ruiling Tang, Yanting Su, Shigang Shan, Huifen Dong, Yongfen Bao, Lihua Qu   +15 more
doaj   +1 more source

Epigenome Modifying Tools In Asthma [PDF]

, 2015
Adcock,, Brook, PO, Durham, AL, Perry, M
core   +1 more source

Design and characterization of G-quadruplex RNA aptamers reveal RNA-binding by KDM5 lysine demethylases

Computational and Structural Biotechnology Journal
Here, we show that the histone lysine demethylases KDM5A and KDM5B can bind to RNA through interaction with G-quadruplexes, despite neither being categorized as RNA- nor G-quadruplex binding proteins across numerous experimental large-scale and ...
Johanna Luige, Thomas Conrad, Alexandros Armaos, Annita Louloupi, Anna Vincent, David Meierhofer, Michael Gajhede, Gian Gaetano Tartaglia, Ulf Andersson Vang Ørom   +8 more
doaj   +1 more source