Results 31 to 40 of about 25,929 (279)

Targeting Histone Demethylases in MYC-Driven Neuroblastomas with Ciclopirox [PDF]

, 2017
Histone lysine demethylases facilitate the activity of oncogenic transcription factors, including possibly MYC. Here we show that multiple histone demethylases influence the viability and poor prognosis of neuroblastoma cells, where MYC is often ...
Milasta, S, Rodrigo B. Interiano, Wenwei Lin, Hu, Dongli, Mishra, Ashutosh, Cheng, Y, Peng, J, Ong, Su Sien, Zheng, Jie J, Mishra, A, Goh, Pollyanna, Ruoning Wang, Goh, P, Shelat, A, Chunxu Qu, Jun Yang, Su Sien Ong, Sandra Milasta, Li, Zhenmei, Zhou, J, Nathwani, Amit C, AlTahan, AM, Vincent A. Boyd, Yang, J, Alaa M. AlTahan, Davidson, Jesse, Ong, SS, White, Stephen, Lin, Wenwei, Qu, C, Guy, R Kiplin, Low, J, Zhenmei Li, Anang Shelat, Green, Douglas R, Boyd, VA, Yinan Wu, Jie J. Zheng, Peng, Junmin, Davidson, J, Dongli Hu, Hu, D, Wang, Ruoning, Milasta, Sandra, Stephen White, Low, Jonathan, Wang, Yingdi, AlTahan, Alaa M, Jonathan Low, Interiano, Rodrigo B, Das, Sourav, Das, S, Junfang Zhou, Zhou, Junfang, Brandon Young, Chen, T, Wu, Yinan, Cheng, Yong, Ashutosh Mishra, Douglas R. Green, Shelat, Anang, Bao, J, Amit C. Nathwani, Qu, Chunxu, R. Kiplin Guy, Chen, Taosheng, Young, B, Zheng, JJ, Wu, Y, Young, Brandon, Wang, R, Davidoff, Andrew M, Yong Cheng, Boyd, Vincent A, Bao, Ju, Wang, Y, Sourav Das, Yang, Jun, Guy, RK, Jesse Davidson, Taosheng Chen, Nathwani, AC, Li, Z, Green, DR, Davidoff, AM, Lin, W, Pollyanna Goh, Interiano, RB, White, S, Andrew M. Davidoff, Ju Bao, Yingdi Wang, Junmin Peng   +92 more
core   +1 more source

Environmental Enrichment Reverses Histone Methylation Changes in the Aged Hippocampus and Restores Age-Related Memory Deficits

Biology, 2015
A decline in long-term memory (LTM) formation is a common feature of the normal aging process, which corresponds with abnormal expression of memory-related genes in the aged hippocampus. Epigenetic modulation of chromatin structure is required for proper
Sarah J. Morse, Anderson A. Butler, Robin L. Davis, Ian J. Soller, Farah D. Lubin   +4 more
doaj   +1 more source

SMARCA4 deficient tumours are vulnerable to KDM6A/UTX and KDM6B/JMJD3 blockade

Nature Communications, 2021
SMARCA4 is commonly inactivated in lung and ovarian cancers. Here the authors show that SMARCA4-deficient tumours have significantly reduced levels of the histone demethylases KDM6s and a strong dependency on these demethylases for tumour growth, so that
Octavio A. Romero, Andrea Vilarrubi, Juan J. Alburquerque-Bejar, Antonio Gomez, Alvaro Andrades, Deborah Trastulli, Eva Pros, Fernando Setien, Sara Verdura, Lourdes Farré, Juan F. Martín-Tejera, Paula Llabata, Ana Oaknin, Maria Saigi, Josep M. Piulats, Xavier Matias-Guiu, Pedro P. Medina, August Vidal, Alberto Villanueva, Montse Sanchez-Cespedes   +19 more
doaj   +1 more source

JMJD3 is a histone H3K27 demethylase [PDF]

Cell Research, 2007
Histone methylation is an important epigenetic phenomenon that participates in a diverse array of cellular processes and has been found to be associated with cancer. Recent identification of several histone demethylases has proved that histone methylation is a reversible process.
Yang, Xiang, Ziqi, Zhu, Gang, Han, Hanqing, Lin, Longyong, Xu, Charlie Degui, Chen   +5 more
openaire   +2 more sources

Integrative genomic analysis identifies associations of molecular alterations to APOBEC and BRCA1/2 mutational signatures in breast cancer

Molecular Genetics & Genomic Medicine, 2019
Background The observed mutations in cancer are the result of ~30 mutational processes, which stamp particular mutational signatures (MS). Nevertheless, it is still not clear which genomic alterations correlate to several MS.
Victor Trevino
doaj   +1 more source

Oncometabolite D-2-Hydroxyglutarate enhances gene silencing through inhibition of specific H3K36 histone demethylases

eLife, 2017
Certain mutations affecting central metabolism cause accumulation of the oncometabolite D-2-hydroxyglutarate which promotes progression of certain tumors.
Ryan Janke, Anthony T Iavarone, Jasper Rine   +2 more
doaj   +1 more source

Current Perspectives on Histone Demethylases [PDF]

Acta Biochimica et Biophysica Sinica, 2007
The posttranslational modification of histones plays an important role in chromatin regulation. Histone methylation influences constitutive heterochromatin, genomic imprinting, X-chromosome inactivation and gene transcription. Histone demethylase catalyzes the removal of methyl groups on lysine or arginine residues of histones.
Xiaoqing, Tian, Jingyuan, Fang
openaire   +2 more sources

Histone Demethylases in Colon Cancer [PDF]

Current Colorectal Cancer Reports, 2014
Cell growth and proliferation are controlled through different posttranslational modifications including demethylation, a process regulated by regulated by the demethylase enzymes. This review focuses on our current understanding of functional and therapeutic potentials of histone demethylases in colon cancer.
Santanu, Paul, Satish, Ramalingam, Dharmalingam, Subramaniam, Joaquina, Baranda, Shrikant, Anant, Animesh, Dhar   +5 more
openaire   +2 more sources

Relationship between histone demethylase LSD family and development and prognosis of gastric cancer

Frontiers in Immunology, 2023
Objectiveto elucidate the correlation between histone demethylase and gastric cancerResearch objecthistone demethylase and gastric cancerResultsAs one of the important regulatory mechanisms in molecular biology and epigenetics, histone modification plays
Liyan Dong, Jiaxing Zhu, Anyi Deng, Junping Wei, Jiawei Li, Xinru Mao, Zhenghu Jia, Zhenghu Jia, Zhenghu Jia   +8 more
doaj   +1 more source

Histone H4K20 Demethylation by Two hHR23 Proteins

Cell Reports, 2020
Summary: Histone methyl groups can be removed by demethylases. Although LSD1 and JmjC domain-containing proteins have been identified as histone demethylases, enzymes for many histone methylation states or sites are still unknown.
Xiongwen Cao, Yanran Chen, Bin Wu, Xiaoyun Wang, Hongjuan Xue, Lu Yu, Jie Li, Yiqin Wang, Wei Wang, Qing Xu, Hailei Mao, Chao Peng, Gang Han, Charlie Degui Chen   +13 more
doaj   +1 more source