Results 31 to 40 of about 53,955 (247)
HP1 maintains protein stability of H3K9 methyltransferases and demethylases
EMBO Reports, 2022 Di‐ or tri‐methylated H3K9 (H3K9me2/3) is an epigenetic mark of heterochromatin. Heterochromatin protein 1 (HP1) specifically recognizes H3K9me2/3, contributing to transcriptional suppression and spread of H3K9me2/3.
Ryo Maeda, M. Tachibana
semanticscholar +1 more source
Histone Lysine Demethylase Inhibitors [PDF]
Cold Spring Harbor Perspectives in Medicine, 2016 The dynamic regulation of covalent modifications to histones is essential for maintaining genomic integrity and cell identity and is often compromised in cancer. Aberrant expression of histone lysine demethylases has been documented in many types of blood and solid tumors, and thus demethylases represent promising therapeutic targets.
Ashwini, Jambhekar +2 more
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Current Issues in Molecular Biology, 2023 Epigenetic studies on the role of DNA-modifying enzymes in HNSCC tumorigenesis have focused on a single enzyme or a group of enzymes. To acquire a more comprehensive insight into the expression profile of methyltransferases and demethylases, in the ...
Larisa Goričan +5 more
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Association of N6-methyladenosine with viruses and virally induced diseases
Frontiers in Bioscience-Landmark, 2020 N6-methyladenosine (m6A) modification, which alters gene expression, is the most prevalent internal modification of eukaryotic mRNA. m6A modification is dynamic and reversible that is regulated by three associated protein groups: methyltransferases or ...
Fang Wu +5 more
doaj +1 more source
Biology, 2015 A decline in long-term memory (LTM) formation is a common feature of the normal aging process, which corresponds with abnormal expression of memory-related genes in the aged hippocampus. Epigenetic modulation of chromatin structure is required for proper
Sarah J. Morse +4 more
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Frontiers in Oncology, 2020 Objectives: This study aims to explore the roles of 13 m6A RNA methylation regulators in clear cell renal cell carcinoma (ccRCC), and identify a risk signature and prognostic values of m6A RNA methylation regulators in ccRCC.Materials and Methods: RNA ...
Jiawu Wang +4 more
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Frontiers in Cell and Developmental Biology, 2021 The cellular RNA can acquire a variety of chemical modifications during the cell cycle, and compelling pieces of evidence highlight the importance of these modifications in determining the metabolism of RNA and, subsequently, cell physiology.
Mahmoud Bayoumi +2 more
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Histone demethylase lysine demethylase 5B in development and cancer
Oncotarget, 2016 Histone methylation is one of the most important chromatin posttranslational modifications. It has a range of influences on nuclear functions including epigenetic inheritance, transcriptional regulation and the maintenance of genome integrity. Changes in histone methylation status take part in various physiological and pathological processes.
Han, Mengjiao +4 more
openaire +3 more sources
Epigenetic Changes in Host Ribosomal DNA Promoter Induced by an Asymptomatic Plant Virus Infection
Biology, 2020 DNA cytosine methylation is one of the main epigenetic mechanisms in higher eukaryotes and is considered to play a key role in transcriptional gene silencing.
Miryam Pérez-Cañamás +2 more
doaj +1 more source
chroGPS, a global chromatin positioning system for the functional analysis and visualization of the epigenome [PDF]
, 2013 Development of tools to jointly visualize the genome and the epigenome remains a challenge. chroGPS is a computational approach that addresses this question.
Font-Burgada, Joan +3 more
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