Results 11 to 20 of about 53,955 (247)
The JMJD Family Histone Demethylases in Crosstalk Between Inflammation and Cancer
Frontiers in Immunology, 2022 Inflammation has emerged as a key player in regulating cancer initiation, progression, and therapeutics, acting as a double edged sword either facilitating cancer progression and therapeutic resistance or inducing anti-tumor immune responses ...
Jia Yang +4 more
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Cells, 2022 Epigenetic regulation of gene expression is crucial to the determination of cell fate in development and differentiation, and the Polycomb (PcG) and Trithorax (TrxG) groups of proteins, acting antagonistically as complexes, play a major role in this ...
Joyce Taylor-Papadimitriou +1 more
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Detailed resume of RNA m6A demethylases
Acta Pharmaceutica Sinica B, 2022 N6-Methyladenosine (m6A) is the most abundant internal modification in eukaryotic mRNA, playing critical role in various bioprocesses. Like other epigenetic modifications, m6A modification can be catalyzed by the methyltransferase complex and erased ...
Dandan Shen +13 more
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The KDM4/JMJD2 histone demethylases are required for hematopoietic stem cell maintenance [PDF]
Blood, 2019 KDM4/JMJD2 are H3K9- and H3K36-specific demethylases, which are considered promising therapeutic targets for the treatment of acute myeloid leukemia (AML) harboring MLL translocations. Here, we investigate the long-term effects of depleting KDM4 activity
Agger, Karl +5 more
core +3 more sources
A new role for histone demethylases in the maintenance of plant genome integrity
eLife, 2020 Histone modifications deposited by the Polycomb repressive complex 2 (PRC2) play a critical role in the control of growth, development, and adaptation to environmental fluctuations of most multicellular eukaryotes.
Javier Antunez-Sanchez +17 more
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Targeting histone methyltransferases and demethylases in clinical trials for cancer therapy [PDF]
Clinical Epigenetics, 2016 Drawing of Object No ...
Ludovica Morera +2 more
core +2 more sources
Identification of Novel Alternative Transcripts of the Human ALKBH Gene Family and Investigation of Their Unique Expression Signatures in Cancer Cells [PDF]
Current Issues in Molecular BiologyThe human ALKBH gene family comprises nine Fe2+/α-ketoglutarate-dependent dioxygenases that catalyze the oxidative demethylation of DNA, RNA, and proteins, thereby influencing key cellular processes.
Konstantina Athanasopoulou +4 more
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Roles of KDM5 demethylases in therapeutic resistance of cancers [PDF]
Epigenetics & ChromatinEpigenetic modifications, including the regulation of histone H3 lysine 4 methylation (H3K4me2/3), play critical roles in maintaining normal tissue homeostasis and influencing the progression of cancer, including growth, invasion, metastasis, and ...
Xiaobo Chen +7 more
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PLoS ONE, 2019 DNA methylation through the activity of cytosine-5-methyltransferases (C5-MTases) and DNA demethylases plays important roles in genome protection as well as in regulating gene expression during plant development and plant response to environmental ...
Andrea Moglia +6 more
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Identification and expression analysis of N6-methyltransferase and demethylase in rapeseed (Brassica napus L.) [PDF]
BMC GenomicsBackground N 6 -methyladenosine (m6A) modification involves the addition of a methyl group to the nitrogen atom at position six of adenine in RNA. It is the most prevalent type of dynamic internal RNA methylation modification, plays an important role in ...
Xiaoyu Chen +9 more
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