Results 11 to 20 of about 25,929 (279)
Detailed resume of RNA m6A demethylases
Acta Pharmaceutica Sinica B, 2022 N6-Methyladenosine (m6A) is the most abundant internal modification in eukaryotic mRNA, playing critical role in various bioprocesses. Like other epigenetic modifications, m6A modification can be catalyzed by the methyltransferase complex and erased ...
Dandan Shen +13 more
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Histone demethylases in autophagy and inflammation
Cell Communication and SignalingAutophagy dysfunction is associated with changes in autophagy-related genes. Various factors are connected to autophagy, and the mechanism regulating autophagy is highly complicated. Epigenetic changes, such as aberrant expression of histone demethylase,
Yaoyao Ma +15 more
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CTCF and Its Multi-Partner Network for Chromatin Regulation
Cells, 2023 Architectural proteins are essential epigenetic regulators that play a critical role in organizing chromatin and controlling gene expression. CTCF (CCCTC-binding factor) is a key architectural protein responsible for maintaining the intricate 3D ...
Aylin Del Moral-Morales +5 more
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The Methylation Game: Epigenetic and Epitranscriptomic Dynamics of 5-Methylcytosine
Frontiers in Cell and Developmental Biology, 2022 DNA and RNA methylation dynamics have been linked to a variety of cellular processes such as development, differentiation, and the maintenance of genome integrity.
Adele Alagia, Monika Gullerova
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The Discovery of Histone Demethylases [PDF]
Cold Spring Harbor Perspectives in Biology, 2013 Histone methylation is a key element of the eukaryotic epigenome. Since the discovery of the first histone demethylase (HDM) in 2004, more than 20 demethylases have been identified and characterized. They belong to either the LSD family or the JmjC family, demonstrating the reversibility of all methylation states at almost all major histone lysine ...
Yujiang Geno, Shi, Yuichi, Tsukada
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Frontiers in Plant Science, 2021 Trimethylation of histone H3 lysine 27 (H3K27me3) is a highly conserved repressive histone modification that signifies transcriptional repression in plants and animals.
Nobutoshi Yamaguchi
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Biology, 2022 Methylation at the N6-position of adenosine (N6mA) on mRNA (m6A) is one of the most widespread, highly selective and dynamically regulated RNA modifications and plays an important role in transcription and translation.
Congshan Liu +3 more
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Histone Methylation Related Therapeutic Challenge in Cardiovascular Diseases
Frontiers in Cardiovascular Medicine, 2021 The epidemic of cardiovascular diseases (CVDs) is predicted to spread rapidly in advanced countries accompanied by the high prevalence of risk factors.
Yang Yang +3 more
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Molecular Cell, 2010 Histone-modifying enzymes require recruitment to specific genomic loci in order to elicit their effects. In this issue, Kleine-Kohlbrecher et al. reveal how a histone demethylase is targeted to specific genes, thereby providing mechanistic insight into recruitment and regulation.
Dawson, Mark A., Bannister, Andrew J.
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The JMJD Family Histone Demethylases in Crosstalk Between Inflammation and Cancer
Frontiers in Immunology, 2022 Inflammation has emerged as a key player in regulating cancer initiation, progression, and therapeutics, acting as a double edged sword either facilitating cancer progression and therapeutic resistance or inducing anti-tumor immune responses ...
Jia Yang +4 more
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