Results 21 to 30 of about 25,929 (279)
Chromatin and oxygen sensing in the context of JmjC histone demethylases [PDF]
, 2014 Responding appropriately to changes in oxygen availability is essential for multicellular organism survival. Molecularly, cells have evolved intricate gene expression programmes to handle this stressful condition.
Batie, Michael +3 more
core +1 more source
PITX1, a specificity determinant in the HIF-1α-mediated transcriptional response to hypoxia [PDF]
, 2014 A17 Hypoxia is an important developmental cue for multicellular organisms but it is also a contributing factor for several human pathologies, such as stroke, cardiovascular diseases and cancer.
Michael Batie (681257) +15 more
core +1 more source
Current Issues in Molecular Biology, 2023 Epigenetic studies on the role of DNA-modifying enzymes in HNSCC tumorigenesis have focused on a single enzyme or a group of enzymes. To acquire a more comprehensive insight into the expression profile of methyltransferases and demethylases, in the ...
Larisa Goričan +5 more
doaj +1 more source
Histone demethylase lysine demethylase 5B in development and cancer
Oncotarget, 2016 Histone methylation is one of the most important chromatin posttranslational modifications. It has a range of influences on nuclear functions including epigenetic inheritance, transcriptional regulation and the maintenance of genome integrity. Changes in histone methylation status take part in various physiological and pathological processes.
Han, Mengjiao +4 more
openaire +3 more sources
Association of N6-methyladenosine with viruses and virally induced diseases
Frontiers in Bioscience-Landmark, 2020 N6-methyladenosine (m6A) modification, which alters gene expression, is the most prevalent internal modification of eukaryotic mRNA. m6A modification is dynamic and reversible that is regulated by three associated protein groups: methyltransferases or ...
Fang Wu +5 more
doaj +1 more source
The Functions of the Demethylase JMJD3 in Cancer [PDF]
International Journal of Molecular Sciences, 2021 Cancer is a major cause of death worldwide. Epigenetic changes in response to external (diet, sports activities, etc.) and internal events are increasingly implicated in tumor initiation and progression. In this review, we focused on post-translational changes in histones and, more particularly, the tri methylation of lysine from histone 3 (H3K27me3 ...
Sanchez, Anna +6 more
openaire +3 more sources
Frontiers in Oncology, 2020 Objectives: This study aims to explore the roles of 13 m6A RNA methylation regulators in clear cell renal cell carcinoma (ccRCC), and identify a risk signature and prognostic values of m6A RNA methylation regulators in ccRCC.Materials and Methods: RNA ...
Jiawu Wang +4 more
doaj +1 more source
H3K56me3 is a novel, conserved heterochromatic mark that largely but not completely overlaps with H3K9me3 in both regulation and localization. [PDF]
, 2013 Histone lysine (K) methylation has been shown to play a fundamental role in modulating chromatin architecture and regulation of gene expression. Here we report on the identification of histone H3K56, located at the pivotal, nucleosome DNA entry/exit ...
Pünzeler, Sebastian +29 more
core +1 more source
Epigenetic Changes in Host Ribosomal DNA Promoter Induced by an Asymptomatic Plant Virus Infection
Biology, 2020 DNA cytosine methylation is one of the main epigenetic mechanisms in higher eukaryotes and is considered to play a key role in transcriptional gene silencing.
Miryam Pérez-Cañamás +2 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2021 The cellular RNA can acquire a variety of chemical modifications during the cell cycle, and compelling pieces of evidence highlight the importance of these modifications in determining the metabolism of RNA and, subsequently, cell physiology.
Mahmoud Bayoumi +2 more
doaj +1 more source