Results 21 to 30 of about 53,955 (247)
H3K56me3 is a novel, conserved heterochromatic mark that largely but not completely overlaps with H3K9me3 in both regulation and localization. [PDF]
, 2013 Histone lysine (K) methylation has been shown to play a fundamental role in modulating chromatin architecture and regulation of gene expression. Here we report on the identification of histone H3K56, located at the pivotal, nucleosome DNA entry/exit ...
Bussemer, Silva +9 more
core +17 more sources
CTCF and Its Multi-Partner Network for Chromatin Regulation
Cells, 2023 Architectural proteins are essential epigenetic regulators that play a critical role in organizing chromatin and controlling gene expression. CTCF (CCCTC-binding factor) is a key architectural protein responsible for maintaining the intricate 3D ...
Aylin Del Moral-Morales +5 more
doaj +1 more source
Histone demethylases in the regulation of immunity and inflammation
Cell Death Discovery, 2023 Pathogens or danger signals trigger the immune response. Moderate immune response activation removes pathogens and avoids excessive inflammation and tissue damage.
L. Qu +10 more
semanticscholar +1 more source
Annals of the Rheumatic Diseases, 2023 Objectives In osteoarthritis, methylation of lysine 79 on histone H3 (H3K79me), a protective epigenetic mechanism, is reduced. Histone methylation levels are dynamically regulated by histone methyltransferases and demethylases. Here, we aimed to identify
Reem Assi +9 more
semanticscholar +1 more source
The Methylation Game: Epigenetic and Epitranscriptomic Dynamics of 5-Methylcytosine
Frontiers in Cell and Developmental Biology, 2022 DNA and RNA methylation dynamics have been linked to a variety of cellular processes such as development, differentiation, and the maintenance of genome integrity.
Adele Alagia, Monika Gullerova
doaj +1 more source
Nature Communications, 2021 Acclimation to high temperature increases plants’ tolerance of subsequent lethal high temperatures. Although epigenetic regulation of plant gene expression is well studied, how plants maintain a memory of environmental changes over time remains unclear ...
Nobutoshi Yamaguchi +16 more
semanticscholar +1 more source
Molecular Cell, 2010 Histone-modifying enzymes require recruitment to specific genomic loci in order to elicit their effects. In this issue, Kleine-Kohlbrecher et al. reveal how a histone demethylase is targeted to specific genes, thereby providing mechanistic insight into recruitment and regulation.
Dawson, Mark A., Bannister, Andrew J.
openaire +2 more sources
Therapeutic potential of inhibiting histone 3 lysine 27 demethylases: a review of the literature
Clinical Epigenetics, 2022 Histone 3 lysine 27 (H3K27) demethylation constitutes an important epigenetic mechanism of gene activation. It is mediated by the Jumonji C domain-containing lysine demethylases KDM6A and KDM6B, both of which have been implicated in a wide myriad of ...
J. Abu-Hanna +6 more
semanticscholar +1 more source
Recent Advances of m6A Demethylases Inhibitors and Their Biological Functions in Human Diseases
International Journal of Molecular Sciences, 2022 N6-methyladenosine (m6A) is a post-transcriptional RNA modification and one of the most abundant types of RNA chemical modifications. m6A functions as a molecular switch and is involved in a range of biomedical aspects, including cardiovascular diseases,
Y. You +7 more
semanticscholar +1 more source