Results 91 to 100 of about 16,538 (257)

The RNA Methyltransferase METTL3 Promotes Oncogene Translation [PDF]

Cancer Discovery, 2016
Abstract METTL3 enhances translation independent of methyltransferase activity and methyl reader proteins.
openaire   +2 more sources

SCTR–Expressing Astrocyte–Serotonergic Neuron Signaling Drives Sexual Dimorphism in Depression Through KAT7/H4ac–Foxc2 Epigenetic Axis in an AMPK‐Dependent Manner

Advanced Science, EarlyView.
Astrocytic SCTR modulates depressive‐related phenotypes via AMPKα1, whereas lowered Mt1 blunts Megalin‐dependent AMPKα2 signaling in serotonergic neurons. Diminished AMPKα2 hinders KAT7 nuclear translocation, curtails KAT7 occupancy and H4K8ac at the Foxc2 promoter, and represses Foxc2 transcription, revealing cell‐type‐specific AMPK‐linked epigenetic ...
Fantao Meng, Jing Liu, Juanjuan Dai, Min Wu, Wentao Wang, Mengdi Zhang, Shujun Jiang, Yifan Cao, Lihong Xu, Lin Du, Dan Wang, Di Zhao, Gaofeng Qin, Dong Wang, Wei Li, Chen Li   +15 more
wiley   +1 more source

Lactate Signal: Modulator of Cellular Energy Production and Anabolism

Advanced Science, EarlyView.
Compartmentalized lactate signaling provides a spatial framework for understanding how lactate‐rich states are generated, transported, sensed, and translated into biological outputs. This Review integrates extracellular, cytosolic, mitochondrial‐associated, and nuclear lactate mechanisms to explain how lactate shapes metabolic adaptation, immune ...
Han Wang, Si‐Yuan Yang, Wei Xu
wiley   +1 more source

METTL3 promotes the proliferation and mobility of gastric cancer cells

, 2019
Methyltransferase-like 3 (METTL3) was originally known to be responsible for N6-methyladenosine (m6A) modification of mRNA. Recent studies have found that METTL3 plays important roles in a variety of tumors by regulating the translation of oncogenes ...
Chen Yuan, Wang Xuexiang, Sun Chao, Wang Peng, Lin Sen, Liu Jianing, Jiang Wen, Wang Hongbo   +7 more
core   +1 more source

Ligand binding states determine METTL3 phase transition.

, 2022
(A) Representative images (left) and quantitation (right) representing demixing of Cry2-mCh-METTL3 D395A (catalytic motif, SAM binding pocket) or N549A/Q550A (SAM binding pocket) mutants after (blue dot) blue light stimulation. Scale bar = 10 μm.
Vivian Hoang (12072856), Xuemei Zhang (89768), Kenneth S. Kosik (7435415), Dasol Han (7435397), Andrew P. Longhini (11007554), Maxwell Z. Wilson (9930238)   +5 more
core   +1 more source

β‐Adducin Restrains PLA2G4A‐Dependent Lysosomal Membrane Permeabilization and Neuronal Death in Ischemic Stroke

Advanced Science, EarlyView.
This study identifies β‐adducin as a regulator of lysosomal integrity in ischemic neurons. Ischemia‐associated FTO loss increases m6A modification and destabilizes Add2 mRNA, reducing β‐adducin expression and promoting PLA2G4A accumulation at lysosomes.
Hui‐qin Li, Pin‐yi Liu, Dan Wu, Fei‐yu Ma, Yi Bai, Sheng‐nan Xia, Hai‐yan Yang, Xin‐yu Bao, Yun Xu, Xiang Cao   +9 more
wiley   +1 more source

METTL3 contribution to cell proliferation in Thymic Epithelial Tumor Cells

, 2022
Thymic epithelial tumors (TETs) are rare neoplasms, originated from epithelial thymic cells. The oncogenic potential of these rare neoplasms is still largely undefined and a deeper molecular characterization could result in a relevant advance in their ...
Andrea Sacconi, Giovanni Blandino, Silvia Masciarelli, Vincenzo Petrozza, Luciana De Angelis, Zaira Ianniello, Valentina Laquintana, Giulia Fontemaggi, Francesco Fazi, Federica Ganci, Francesco Facciolo, Enzo Gallo, Mirella Marino, Sara Aversa, Alessandro Fatica, Enrico Melis, Daniele Diso, Claudia Tito, Alessia Iaiza, Marco Anile, Edoardo Pescarmona, Federico Venuta   +21 more
core  

USP25 deubiquitinates cytosolic METTL3 to impede glioma proliferation via an m6A-independent pathway

iScience
Summary: METTL3 exhibits distinct tumorigenic roles in the nucleus and cytoplasm, but whether its post-transcriptional modifications vary by subcellular localization remains unclear.
Bingchang Zhang, Wanhong Han, Xin Gao, Wenhua Li, Jianhua Yu, Wujie Zhao, Jiawei He, Xiansheng Qiu, Zhenwei Lu, Liwei Zhou, Yahui Hu, Yuanyuan Xie, Yanyan Geng, Hanwen Lu, Wentao Zhao, Xinwen Liao, Shouren Chen, Xiyao Liu, Sifang Chen, Guowei Tan, Yaya Zhang, Zhanxiang Wang   +21 more
doaj   +1 more source

Ultrasound‐Triggered piRNA Delivery Using Biomimetic Phase‐Changeable Nanoparticles for Theranostics of Myocardial Infarction

Advanced Science, EarlyView.
A biomimetic ultrasound‐responsive piRNA delivery nanoparticle platform (piR‐NPs) enables targeted delivery and ultrasound (US)‐triggered release of piR‐1873 in infarcted myocardium. The released piR‐1873 suppresses Usp2‐mediated RIP1/RIP3/MLKL necroptosis, reduces myocardial injury and fibrosis, and promotes cardiac functional recovery, providing a ...
Yajun Zhang, Hongzhao Qi, Yanyan Yang, Feng Wang, Tiantian Han, Yanbei Lei, Xiaolu Li, Zhibin Wang, Hua Qu, Tao Yu, Pin Sun   +10 more
wiley   +1 more source

Regulatory role of the METTL3/MALAT1 axis in multiple myeloma progression

Journal of Bone Oncology
Objective: Methyltransferase-like 3 (METTL3) plays a crucial role in cancer progression, both in m6A modification-dependent and −independent pathways. We aimed to elucidate the mechanism by which METTL3 and the long noncoding RNA metastasis-associated ...
Xiaohong Lu, Yafei Li, Ruie Li, Jingheng Zhang, Jiayu Peng, Yan Zhang   +5 more
doaj   +1 more source