Results 91 to 100 of about 13,391 (192)

METTL3-mediated miR-4534 maturation promotes IVDD progression by targeting the Sirt6-mediated Nrf2/HO-1 pathway

Archives of Medical Science
Introduction Intervertebral disc degeneration (IVDD) is a significant contributor to the development of discogenic low back pain and impairment. Apoptosis and degradation of the extracellular matrix (ECM) have also been reported to be major factors in ...
Bo Ran, Ziqing Yang, Mengzhao Li
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Compound 21 Attenuates Isoflurane-Induced Injury in Neonatal Rat Hippocampal Neurons and Primary Rat Neuronal Cells by Upregulating METTL3

Journal of Inflammation Research
Yaping Shen,1,2,* Yijiu Wu,3,* Hai Zhuang,4 Zhumei Chen,5 Qiong Zhang,5 Peixin Li,5 Jing Wang,3 Zhi Huang,1 Qingfan Zeng3,5 1Department of Interventional Radiology, The Affiliated Hospital of Guizhou Medical University, Guiyang, 550002, People’s ...
Shen Y, Wu Y, Zhuang H, Chen Z, Zhang Q, Li P, Wang J, Huang Z, Zeng Q   +8 more
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Downregulated METTL3 Accumulates TERT Expression that Promote the Progression of Ovarian Endometriosis

Frontiers in Bioscience-Landmark
Background: Endometriosis is a complicated and enigmatic disease that significantly diminishes the quality of life for women affected by this condition.
Fang Li, Hua Tao, Yini Wei, Ru Meng, Yushan Li, Lifang Nie, Yu Zhang, Jinjun Chang   +7 more
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RNA Binding by the m6A Methyltransferases METTL16 and METTL3

Biology
Methyltransferases are a wide-ranging, yet well-conserved, class of molecules that have been found to modify a wide variety of substrates. Interest in RNA methylation has surged in recent years with the identification of the major eukaryotic mRNA m6A methyltransferase METTL3.
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METTL3-Mediated N6-Methyladenosine Ferroptosis in Sepsis-Associated Acute Lung Injury — A Narrative Review

Frontiers in Bioscience-Landmark
Sepsis-induced acute lung injury (ALI) represents a complex and life-threatening condition with limited therapeutic options. Recent research has unveiled the role of methyltransferase-like 3 (METTL3)-mediated N6-methyladenosine (m6A) modifications in ...
Rinki Kumari, Roger Leng, Brian Chiu, Consolato M. Sergi   +3 more
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Author Response: A cleaved METTL3 potentiates the METTL3–WTAP interaction and breast cancer progression

, 2023
Chaojun Yan, Jingjing Xiong, Zirui Zhou, Qifang Li, Chuan Gao, Mengyao Zhang, Liya Yu, Jinpeng Li, Ming-Ming Hu, Chen-Song Zhang, Cheguo Cai, Haojian Zhang, Jing Zhang   +12 more
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BE screen reveals METTL3 S2 dephosphorylation sensitizes gastric cancer cells to oxaliplatin by interfering METTL3-eIF3H interaction

Science Advances
The resistance to oxaliplatin (OXA)–based chemotherapies may lead to poor prognosis in patients with gastric cancer (GC). Emerging evidence suggests that resistance is closely associated with phosphorylation modifications. In GC cell line AGS, high-throughput base editor screen identified key phosphorylation sites associated with ...
Xiaoran Xu, Wanyu Tao, Yixin Liu, Tangxi Guo, Yu Zhang, Dongyi Wei, Picheng Yan, Xingxu Huang, Yongchang Wei   +8 more
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p65 enhanced METTL3-mediated m6A methylation of HMGB1 to promote microglia M1 polarization in sepsis-associated encephalopathy

Central European Journal of Immunology
Introduction Sepsis-associated encephalopathy (SAE) is a complication posing a significant risk to patient health and survival. Microglial polarization and inflammation are key to the pathological progression of SAE. The p65 subunit is a component of the 
Xiaowen Wu, Jie Wang, Jun Li, Guosheng Yao, Linyun Wei, Xuebin Li   +5 more
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METTL3-mediated methylation of CYP2C19 mRNA may aggravate clopidogrel resistance in ischemic stroke patients

Open Medicine
N6-methyladenosine (m6A) is the most frequently occurring interior modification in eukaryotic messenger RNA (mRNA), and abnormal mRNA modifications can affect many biological processes.
Tan Quandan, Yang Le, Yuan Shanshan, Zheng Danni, Lin Yapeng, Chen Kejie, He Ying, Chen Shuntian, Hao Junli, Dai Jin, He Song, Mao Fengkai, Leng Xinyi, Jiang Haisong, Yang Jie   +14 more
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METTL3 facilitates renal cell carcinoma progression by PLOD2 m6A-methylation under prolonged hypoxia

Cell Death and Disease
N6-methyladenosine (m6A) is the most prevalent reversible modification in eukaryotic mRNA, and it plays a critical role in tumor progression. The purpose of this study was to investigate the function and regulatory mechanisms of the methyltransferase ...
Yimeng Chen, Yichen He, Zhengsheng Li, Nan Zhang, Cuixing Zhou, Xiaozhou He, Dong Xue   +6 more
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