Results 111 to 120 of about 16,538 (257)
Central European Journal of ImmunologyIntroduction Sepsis-associated encephalopathy (SAE) is a complication posing a significant risk to patient health and survival. Microglial polarization and inflammation are key to the pathological progression of SAE. The p65 subunit is a component of the
Xiaowen Wu +5 more
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Journal of Intelligent Medicine, EarlyView.This dual bibliometric analysis examined 5129 publications and the top 100 most cited publications on bioinformatics and omics in colorectal cancer (2004–2025) from the Web of Science Core Collection. Using SCImago Graphica, VOSviewer, CiteSpace, and R Studio, we analyzed global trends, countries/regions, institutions, journals, authors, references ...
Yue Huang +7 more
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Journal of Inflammation ResearchXuesong Xie,1 Fang Fang2 1Department of Orthopedics, Xiangtan Central Hospital, Xiangtan, 411100, People’s Republic of China; 2Department of Anorectal, Xiangtan Central Hospital, Xiangtan, 411100, People’s Republic of ChinaCorrespondence: Fang Fang ...
Xie X, Fang F
doaj
Frontiers in Bioscience-LandmarkSepsis-induced acute lung injury (ALI) represents a complex and life-threatening condition with limited therapeutic options. Recent research has unveiled the role of methyltransferase-like 3 (METTL3)-mediated N6-methyladenosine (m6A) modifications in ...
Rinki Kumari +3 more
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The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Microglia play an important role in ischemic stroke (IS). However, the molecular regulatory mechanisms underlying microglial ferroptosis in IS remain incompletely understood. In this study, blood samples were collected from 20 IS patients and 15 healthy volunteers.
Ai‐Xia Song +7 more
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WTAP‐Mediated m6A Modification of TXNDC5 mRNA Promotes Cervical Carcinogenesis
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT WT1‐associated protein (WTAP), a core component of the methyltransferase complex, is involved in various tumor pathological processes, but its specific mechanism in cervical cancer (CC) remains unclear. This study, based on single‐cell transcriptomic data (including 3 CC and 2 normal tissues), constructed a CC microenvironment cell atlas ...
Ling Chen +4 more
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The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT N6‐methyladenosine (m6A) plays a critical role in osteoarthritis (OA) pathogenesis. This study investigates the role of the m6A reader insulin‐like growth factor 2 mRNA‐binding protein 3 (IGF2BP3) in OA progression. OA models were established in vivo through destabilization of the medial meniscus (DMM) surgery in mice and in vitro by ...
Xing‐Shi Yuan +8 more
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Recent advances in small molecules targeting the METTL3
Future Medicinal ChemistryN6-methyladenosine (m6A) is the most prevalent internal modification of eukaryotic mRNA, playing a crucial role in the regulation of gene expression. Methyltransferase-like 3 (METTL3), a key catalytic component of the m6A methyltransferase complex, is primarily responsible for the deposition of m6A on target RNA.
Feifei Wu, Lei Yu, Shilin Xu
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Phytotherapy Research, EarlyView.Schematic representation of the shared pathophysiological mechanisms underlying heart failure (HF) and atrial fibrillation (AF), including inflammation, oxidative stress, endothelial dysfunction, and fibrosis. The figure highlights the clinical and mechanistic convergence of conventional pharmacological therapies and selected nutraceuticals in ...
Laura Beatrice Mattioli +6 more
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Phytotherapy Research, EarlyView.Chaetocin induces ferroptosis in cisplatin‐resistant ovarian cancer cells through neddylation‐mediated TFRC upregulation. ABSTRACT Ovarian cancer (OV) is a highly lethal gynecological tumor, often developing platinum chemotherapy resistance and treatment failure.
Hanfei Xie +5 more
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