Results 111 to 120 of about 17,358 (223)

PIWIL4 Acts as a piRNA Binding, Epigenetically Active and Growth Regulatory Protein in Human Acute Myeloid Leukemia [PDF]

, 2017
Piwi proteins are critically important for maintaining the self-renewing stem cell population in lower organisms through epigenetic silencing of transposable elements via DNA methylation and H3K9me3 marks, in close interaction with a novel class of non ...
Aravin, A., Bamezai, S., Borkhardt, A., Buske, C., Feuring-Buske, M., Hoell, J., Kloetgen, A., Mulaw, M., Müller-Tidow, C., Plass, C., Rawat, V. P., Rohde, C., Vegi, N., Zhou, F.   +13 more
core  

NSUN2‐Mediated m5C Methylation and METTL3/METTL14‐Mediated m6A Methylation Cooperatively Enhance p21 Translation [PDF]

, 2017
N6‐methyladenosine (m6A) and m5C methylation are two major types of RNA methylation, but the impact of joint modifications on the same mRNA is unknown.
Dou, Yali, Gorospe, Myriam, Jiang, Bin, Li, Qiu, Li, Xiu, Tang, Hao, Wang, Wengong   +6 more
core   +1 more source

METTL3 facilitates the progression of cervical cancer by m6A modification-mediated up-regulation of NEK2

Scientific Reports
N6-methyladenosine (m6A) is the most prevalent modification found in eukaryotic RNA and played a significant role in various cancers. However, the mechanism by which m6A modification influences cervical cancer (CC) tumorigenesis remains unclear ...
Yilin Guo, Yangyang Bai, Lu Wang, Zhen Xu, Nan Zhang, Wuliang Wang, Hu Zhao   +6 more
doaj   +1 more source

The regulation of PARP proteins by the m⁶A methyltransferase machinery [PDF]

, 2021
RNA methylation is an important regulator of RNA metabolism. The most common form of internal mRNA methylation is N6-methyladenosine (m⁶A), which is deposited by the m6A methyltransferase complex (MTC).
Toolan-Kerr, Patrick
core  

CircABCC1 reduces endometrial receptivity via METTL3/FAM155B axis

The Journal of Maternal-Fetal & Neonatal Medicine
Impaired endometrial receptivity is the main cause of embryo implantation failure. Little information is available on the role of circRNAs in endometrial receptivity. Here, the effect of circABCC1 on endometrial receptivity and its mechanism were investigated.GEO database was screened for key biomarkers for recurrent implantation failure (RIF ...
Lan, Luo, Mi, Tang, Licen, Xie, Xi, Chen, Donghong, Ning, Qiuman, Zheng, Qin, Cao, Ziting, Ouyang   +7 more
openaire   +2 more sources

METTL3 promotes osteoblast ribosome biogenesis and alleviates periodontitis

Clinical Epigenetics
Abstract Background Periodontitis is a highly prevalent oral disease characterized by bacterium-induced periodontal inflammation and alveolar bone destruction. Osteoblast function is impaired in periodontitis with a global proteome change.
Yiwen Zhang, Yiping Kong, Wenjie Zhang, Jinlin He, Zhanqi Zhang, Yongjie Cai, Yiqing Zhao, Qiong Xu   +7 more
openaire   +3 more sources

The METTL3/m6A Reader Protein YTHDF1 Regulates Endothelial Cell Pyroptosis by Enhancing NLRP3 Expression to Affect Soft Tissue Injury

Journal of Inflammation Research
Xuesong Xie,1 Fang Fang2 1Department of Orthopedics, Xiangtan Central Hospital, Xiangtan, 411100, People’s Republic of China; 2Department of Anorectal, Xiangtan Central Hospital, Xiangtan, 411100, People’s Republic of ChinaCorrespondence: Fang Fang ...
Xie X, Fang F
doaj  

METTL3 Promotes mRNA Translation to Drive Tumorigenesis [PDF]

Cancer Discovery, 2018
Abstract METTL3 interacts with eIF3h to enhance the translation efficiency of target mRNAs including BRD4.
openaire   +1 more source

Decreased METTL3 in atrial myocytes promotes atrial fibrillation

Europace
Abstract Aims Methyltransferase like 3 (METTL3) plays a crucial role in cardiovascular diseases, but its involvement in atrial fibrillation (AF) remains unclear.
Jian Shi, Xi-Yu Zhu, Rong-Huang Yu, Wen-Xue Liu, Jie Yang, Lu Tang, Chui-Yu Kong, Han-Qing Luo, Fen Chen, Wen-Sen Xie, Jia-Lei Fu, Jing-Jie Wang, Qian Zhou, Qing Zhou, Dong-Jin Wang   +14 more
openaire   +2 more sources

Compound 21 Attenuates Isoflurane-Induced Injury in Neonatal Rat Hippocampal Neurons and Primary Rat Neuronal Cells by Upregulating METTL3

Journal of Inflammation Research
Yaping Shen,1,2,* Yijiu Wu,3,* Hai Zhuang,4 Zhumei Chen,5 Qiong Zhang,5 Peixin Li,5 Jing Wang,3 Zhi Huang,1 Qingfan Zeng3,5 1Department of Interventional Radiology, The Affiliated Hospital of Guizhou Medical University, Guiyang, 550002, People’s ...
Shen Y, Wu Y, Zhuang H, Chen Z, Zhang Q, Li P, Wang J, Huang Z, Zeng Q   +8 more
doaj