Results 121 to 130 of about 17,358 (223)

Small Extracellular Vesicles Promote HBV Replication via METTL3–IGF2BP2-Mediated m6A Modification

Frontiers in Bioscience-Landmark
Background: The roles of small extracellular vesicles (sEVs) and mRNA modifications in regulating hepatitis B virus (HBV) transmission, replication, and related disease progression have received considerable attention.
Jie Zhang, Ling Yu, Xinyu Wu, Wanlong Pan   +3 more
doaj   +1 more source

Author Response: A cleaved METTL3 potentiates the METTL3–WTAP interaction and breast cancer progression

, 2023
Chaojun Yan, Jingjing Xiong, Zirui Zhou, Qifang Li, Chuan Gao, Mengyao Zhang, Liya Yu, Jinpeng Li, Ming-Ming Hu, Chen-Song Zhang, Cheguo Cai, Haojian Zhang, Jing Zhang   +12 more
openaire   +1 more source

Epigenetic Silencing Rna Methylation Machinery Fto And Mettl3 Associate With Patient Survival In Renal Clear Cell Carcinoma [PDF]

, 2019
Purpose: RNA methylation eraser FTO and writer METTL3 play important roles in human diseases by regulating gene expression. However, the potential of FTO and METTL3 as markers in renal clear cell carcinoma (CCRCC) is still unknown.
Zhao, Jiaxun
core   +1 more source

Proteolysis Targeting Chimera Degraders of the METTL3-14 m$^{6}$A-RNA Methyltransferase [PDF]

Methylation of adenine N6 (m$^{6}$A) is the most frequent RNA modification. On mRNA, it is catalyzed by the METTL3-14 heterodimer complex, which plays a key role in acute myeloid leukemia (AML) and other types of blood cancers and solid tumors.
Bochenkova, Elena, Caflisch, Amedeo, Corbeski, Ivan, Di Fabio, Giovanni, Errani, Francesco, Herok, Marcin, Invernizzi, Annalisa, Romanucci, Valeria, Stamm, Fiona, Zálešák, František   +9 more
core   +1 more source

FOXD2-AS1 is modulated by METTL3 with the assistance of YTHDF1 to affect proliferation and apoptosis in esophageal cancer

Acta Pharmaceutica
This study aims to investigate the regulatory mechanisms of METTL3, YTHDF1, and the long non-coding RNA FOXD2-AS1 in the proliferation and apoptosis of esophageal cancer, with the goal of providing a basis for molecular diagnosis and targeted therapies ...
Wang Zijin, Liu Xing Chen, Gao Zhen Gya, Shi Wo Da, Wang Wen Cai   +4 more
doaj   +1 more source

METTL3-mediated miR-4534 maturation promotes IVDD progression by targeting the Sirt6-mediated Nrf2/HO-1 pathway

Archives of Medical Science
Introduction Intervertebral disc degeneration (IVDD) is a significant contributor to the development of discogenic low back pain and impairment. Apoptosis and degradation of the extracellular matrix (ECM) have also been reported to be major factors in ...
Bo Ran, Ziqing Yang, Mengzhao Li
doaj   +1 more source

Elevated Histone Lactylation Mediates Ferroptosis Resistance in Endometriosis Through the METTL3‐Regulated HIF1A/HMOX1 Signaling Pathway

Advanced Science
Endometriosis (EMs) is a chronic gynecologic condition characterized by the growth of endometrial stromal and glandular tissue outside the uterine cavity of unknown etiology.
Zongwen Liang, Jinming Liu, Yanling Gou, Honglin Wang, Zhi Li, Yingying Cao, Huiyan Zhang, Ruru Bai, Zongfeng Zhang   +8 more
doaj   +1 more source

Downregulated METTL3 Accumulates TERT Expression that Promote the Progression of Ovarian Endometriosis

Frontiers in Bioscience-Landmark
Background: Endometriosis is a complicated and enigmatic disease that significantly diminishes the quality of life for women affected by this condition.
Fang Li, Hua Tao, Yini Wei, Ru Meng, Yushan Li, Lifang Nie, Yu Zhang, Jinjun Chang   +7 more
doaj   +1 more source

METTL3 facilitates renal cell carcinoma progression by PLOD2 m6A-methylation under prolonged hypoxia

Cell Death and Disease
N6-methyladenosine (m6A) is the most prevalent reversible modification in eukaryotic mRNA, and it plays a critical role in tumor progression. The purpose of this study was to investigate the function and regulatory mechanisms of the methyltransferase ...
Yimeng Chen, Yichen He, Zhengsheng Li, Nan Zhang, Cuixing Zhou, Xiaozhou He, Dong Xue   +6 more
doaj   +1 more source

Fate by RNA methylation: m6A steers stem cell pluripotency [PDF]

, 2015
Boxuan Zhao, Chuan He
core   +1 more source