Results 101 to 110 of about 16,538 (257)
Advanced Science, EarlyView.Postoperative arteriovenous fistulas exhibit increased RBMS1 in vascular smooth muscle cells (VSMCs). In experimental AVFs, RBMS1 overexpression aggravates, whereas deletion attenuates, neointimal hyperplasia. RBMS1 binds MPZL1 mRNA and promotes exon 5 skipping to generate MPZL1‐Δ5, which interacts with G3BP1 to activate AKT, driving VSMC proliferation,
Zongda Li +14 more
wiley +1 more source
Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues
ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang +7 more
wiley +1 more source
Advanced ScienceMETTL3, a key enzyme in N6‐methyladenosine (m6A) modification, plays a crucial role in the progression of renal fibrosis, particularly in chronic active renal allograft rejection (CAR).
Qinfan Yao +10 more
doaj +1 more source
iMeta, EarlyView.The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li +29 more
wiley +1 more source
Molecular MedicineObjective METTL3, an m6A methyltransferase, enhances germinal center responses. This study explores its role in lupus B cells and its impact on B-cell activation.
Yiying Yang +9 more
doaj +1 more source
Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials
iNew Medicine, EarlyView.ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong +5 more
wiley +1 more source
Kanoniska och icke-kanoniska funktioner av METTL3 vid bröstcancer
, 2022 Gene expression is spatially and temporally regulated at multiple levels. N6-methyladenosine (m6A) is the most prevalent internal modification in messenger RNA (mRNA) and long noncoding RNA (lncRNAs).
Achour, Cyrinne
core +1 more source
Frontiers in Bioscience-LandmarkBackground: Endometriosis is a complicated and enigmatic disease that significantly diminishes the quality of life for women affected by this condition.
Fang Li +7 more
doaj +1 more source
METTL7B Expression in Sepsis: Association With Disease Severity and 28‐Day Mortality
Journal of Clinical Laboratory Analysis, EarlyView.This prospective cohort study demonstrates that whole blood METTL7B expression is significantly elevated in sepsis patients upon ICU admission and independently associates with disease severity and 28‐day mortality. METTL7B alone predicted 28‐day mortality with an AUC of 0.779, and its combination with dynamic SOFA score and PCT achieved the highest ...
Yuxuan Zhang +3 more
wiley +1 more source
Self-interaction of METTL3 provides multivalency for LLPS of the writer complex.
, 2022 (A) Representative images showing localization of EGFP control, EGFP-METTL14 or EGFP-WTAP after Cry2-mCh-METTL3 condensates formation by light stimulation. Scale bar = 10 μm.
Vivian Hoang (12072856) +5 more
core +1 more source