Results 1 to 10 of about 1,875,668 (207)
Crosstalk between m6A modification and alternative splicing during cancer progression
Clinical and Translational Medicine, 2023 Background N6‐methyladenosine (m6A), the most prevalent internal mRNA modification in eukaryotes, is added by m6A methyltransferases, removed by m6A demethylases and recognised by m6A‐binding proteins.
Zhi‐Man Zhu +4 more
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m6A Modification in Coding and Non-coding RNAs: Roles and Therapeutic Implications in Cancer
Cancer Cell, 2020 N6-Methyladenosine (m6A) RNA modification has emerged in recent years as a new layer of regulatory mechanism controlling gene expression in eukaryotes. As a reversible epigenetic modification found not only in messenger RNAs but also in non-coding RNAs ...
Huilin Huang, Hengyou Weng, Jianjun Chen
exaly +2 more sources
m6A modification: recent advances, anticancer targeted drug discovery and beyond
Molecular Cancer, 2022 Abnormal N6-methyladenosine (m6A) modification is closely associated with the occurrence, development, progression and prognosis of cancer, and aberrant m6A regulators have been identified as novel anticancer drug targets.
Li-Juan Deng +10 more
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The Role of m6A Ribonucleic Acid Modification in the Occurrence of Atherosclerosis
Frontiers in Genetics, 2021 The N6-methyladenosine (m6A) modification is the most abundant epitranscriptomic modification in eukaryotic messenger RNA (mRNA). The m6A modification process is jointly regulated by various enzymes and proteins, such as methyltransferases, demethylases ...
Jie Fu +8 more
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Link Between m6A Modification and Cancers
Frontiers in Bioengineering and Biotechnology, 2018 N6-methyladenosine (m6A) epitranscriptional modification has recently gained much attention. Through the development of m6A sequencing, the molecular mechanism and importance of m6A have been revealed.
Zhen-Xian Liu +3 more
doaj +3 more sources
Genes and Diseases, 2023 N6-methyladenosine (m6A) RNA modification is widely perceived as the most abundant and common modification in transcripts. This modification is dynamically regulated by specific m6A “writers”, “erasers” and “readers” and is reportedly involved in the ...
Lili Feng +5 more
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The role of m6A modification in the biological functions and diseases
Signal Transduction and Targeted Therapy, 2021 N 6 -methyladenosine (m6A) is the most prevalent, abundant and conserved internal cotranscriptional modification in eukaryotic RNAs, especially within higher eukaryotic cells.
Xiulin Jiang +7 more
semanticscholar +1 more source
Frontiers in Genetics, 2021 Objective: N6-methyladenosine (m6A) modification may modulate various biological processes. Nonetheless, clinical implications of m6A modification in pancreatic cancer are undefined.
Kun Fang +6 more
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Molecules and Cells, 2022 Tumor-infiltrating myeloid cells (TIMs) are crucial cell populations involved in tumor immune escape, and their functions are regulated by multiple epigenetic mechanisms.
Jia Xiong +16 more
semanticscholar +1 more source
Pseudorabies virus exploits N6-methyladenosine modification to promote viral replication
Frontiers in Microbiology, 2023 IntroductionPseudorabies virus (PRV) is the pathogenic virus of porcine pseudorabies (PR), belonging to the Herpesviridae family. PRV has a wide range of hosts and in recent years has also been reported to infect humans.
Pei-Lun Yu +21 more
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