Results 31 to 40 of about 1,875,792 (320)
Nature Communications, 2023 m6A modification has been reported to play roles in many developmental and pathological processes, but its role in AKI remains poorly understood.
Juntao Chen +10 more
semanticscholar +1 more source
Analysis of m6A Methylation Modification Patterns and Tumor Immune Microenvironment in Breast Cancer
Frontiers in Cell and Developmental Biology, 2022 Increasing evidence indicates that the abnormal expression of N6-methyladenosine (m6A) modification is closely related to the epigenetic regulation of immune response in breast cancer (BC).
Menglu Dong +4 more
doaj +1 more source
m6a RNA methylation: the implications for health and disease [PDF]
, 2014 The recent resurgence of interest in m6a has been spurred by some intriguing findings detailing the effects and dynamics of this epigenetic modification.
McGuinness, D., Mcguinness, D.H.
core +1 more source
The current landscape of m6A modification in urological cancers
PeerJ, 2023 N6-methyladenosine (m6A) methylation is a dynamic and reversible procession of epigenetic modifications. It is increasingly recognized that m6A modification has been involved in the tumorigenesis, development, and progression of urological tumors. Emerging research explored the role of m6A modification in urological cancer.
Zeng, Yaohui +3 more
openaire +3 more sources
N6-Methyladenosine modification: a novel pharmacological target for anti-cancer drug development
Acta Pharmaceutica Sinica B, 2018 N6-Methyladenosine (m6A) modification is the most pervasive modification of human mRNA molecules. It is reversible via regulation of m6A modification methyltransferase, demethylase and proteins that preferentially recognize m6A modification as “writers”,
Yi Niu +4 more
doaj +1 more source
m6A Methylation in Cardiovascular Diseases: From Mechanisms to Therapeutic Potential
Frontiers in Genetics, 2022 Cardiovascular disease (CVD) is a leading cause of morbidity and mortality worldwide. Recent studies have shown that n6-methyladenosine (m6A) plays a major role in cardiovascular homeostasis and pathophysiology.
Longbo Li +5 more
doaj +1 more source
Molecular Therapy, 2022 Type 2 diabetes mellitus (DM2) is associated closely with Non-alcoholic fatty liver disease (NAFLD) through affecting lipid metabolism, which may lead to non-alcoholic steatohepatitis (NASH), fibrosis and Hepatocellular carcinoma (HCC).
Yeming Yang +11 more
semanticscholar +1 more source
A new perspective on Alzheimer’s disease: m6A modification
Frontiers in Genetics, 2023 As a neurodegenerative disease, Alzheimer’s disease (AD) is characterized by synaptic loss, extracellular plaques of amyloid accumulation, hyperphosphorylation of tau, and neuroinflammation. Various biological processes are affected by epitranscriptomic modifications, which regulate the metabolism of mRNA in cells and regulate the expression of genes ...
Lei Xia +38 more
openaire +3 more sources
The functions of N6-methyladenosine modification in lncRNAs
Genes and Diseases, 2020 Increasing evidence indicates that mRNAs are often subject to posttranscriptional modifications. Among them, N6-methyladenosine (m6A), which has been shown to play key roles in RNA splicing, stability, nuclear export, and translation, is the most ...
Rong-Zhang He, Jing Jiang, Di-Xian Luo
doaj +1 more source
METTL3-mediated m6A modification of TIMP2 mRNA promotes podocyte injury in diabetic nephropathy
Molecular Therapy, 2022 Epigenetic changes are present in many physiological and pathological processes. The N6-methyladenosine (m6A) modification is the most common modification in eukaryotic mRNA.
Ling Jiang +11 more
semanticscholar +1 more source