Results 31 to 40 of about 23,657 (254)

The Potential Roles of RNA N6-Methyladenosine in Urological Tumors

Frontiers in Cell and Developmental Biology, 2020
N6-methyladenosine (m6A) is regarded as the most abundant, prevalent and conserved internal mRNA modification in mammalian cells. M6A can be catalyzed by m6A methyltransferases METTL3, METTL14 and WTAP (writers), reverted by demethylases ALKBH5 and FTO ...
Yang Li, Yu-zheng Ge, Luwei Xu, Zheng Xu, Quanliang Dou, Ruipeng Jia   +5 more
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Characterization of immune microenvironment infiltration and m6A regulator-mediated RNA methylation modification patterns in osteoarthritis

Frontiers in Immunology, 2022
BackgroundFew studies have been reported the potential role of N6-methyladenosine (m6A) modification in osteoarthritis (OA). We investigated the patterns of m6A modification in the immune microenvironment of OA.MethodsWe evaluated the m6A modification ...
Yulong Ouyang, Yuanqing Tu, Shuilin Chen, Huan Min, Zhexu Wen, Guihao Zheng, Ting Wan, Hao Fan, Wenzhao Yang, Guicai Sun   +9 more
doaj   +1 more source

The Emerging Role of m6A Modification in Endocrine Cancer

Cancers, 2023
With the development of RNA modification research, N6-methyladenosine (m6A) is regarded as one of the most important internal epigenetic modifications of eukaryotic mRNA. It is also regulated by methylase, demethylase, and protein preferentially recognizing the m6A modification.
Ji, Xiaoyu, Wang, Zhiyuan, Sun, Wei, Zhang, Hao   +3 more
openaire   +2 more sources

Current insights into the implications of m6A RNA methylation and autophagy interaction in human diseases

Cell & Bioscience, 2021
Autophagy is a conserved degradation process crucial to maintaining the primary function of cellular and organismal metabolism. Impaired autophagy could develop numerous diseases, including cancer, cardiomyopathy, neurodegenerative disorders, and aging ...
Xuechai Chen, Jianan Wang, Muhammad Tahir, Fangfang Zhang, Yuanyuan Ran, Zongjian Liu, Juan Wang   +6 more
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Identification of New m6A Methylation Modification Patterns and Tumor Microenvironment Infiltration Landscape that Predict Clinical Outcomes for Papillary Renal Cell Carcinoma Patients

Frontiers in Cell and Developmental Biology, 2022
N6-methyladenosine (m6A) is the product of the most prevalent mRNA modification in eukaryotic cells. Accumulating evidence shows that tumor microenvironment (TME) plays a pivotal role in tumor development. However, the underlying relationship between m6A
Bin Zheng, Bin Zheng, Bin Zheng, Fajuan Cheng, Fajuan Cheng, Zhongshun Yao, Zhongshun Yao, Yiming Zhang, Yiming Zhang, Zixiang Cong, Zixiang Cong, Zixiang Cong, Jianwei Wang, Zhihong Niu, Zhihong Niu, Wei He, Wei He   +16 more
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Structural Insights into N6-methyladenosine (m6A) Modification in the Transcriptome

Genomics, Proteomics & Bioinformatics, 2018
More than 100 types of chemical modifications in RNA have been well documented. Recently, several modifications, such as N6-methyladenosine (m6A), have been detected in mRNA, opening the window into the realm of epitranscriptomics.
Jinbo Huang, Ping Yin
doaj   +1 more source

WTAP mediates the anti-inflammatory effect of Astragalus mongholicus polysaccharide on THP-1 macrophages

Frontiers in Pharmacology, 2022
Background:Astragalus mongholicus polysaccharides (APS) have anti-inflammatory, antioxidant and immunomodulatory effects. Recent studies have demonstrated the epigenetic regulation of N6-methyladenosine (m6A) in the development of inflammation.
Haijiao Long, Haijiao Long, Haiyue Lin, Pan Zheng, Lianjie Hou, Ming Zhang, Shuyun Lin, Kai Yin, Guojun Zhao, Guojun Zhao   +9 more
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FTO Demethylates Cyclin D1 mRNA and Controls Cell-Cycle Progression

Cell Reports, 2020
Summary: N6-Methyladenosine (m6A) modification is the major chemical modification in mRNA that controls fundamental biological processes, including cell proliferation.
Mayumi Hirayama, Fan-Yan Wei, Takeshi Chujo, Shinya Oki, Maya Yakita, Daiki Kobayashi, Norie Araki, Nozomu Takahashi, Ryoji Yoshida, Hideki Nakayama, Kazuhito Tomizawa   +10 more
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m6A modification: recent advances, anticancer targeted drug discovery and beyond

Molecular Cancer, 2022
Abnormal N6-methyladenosine (m6A) modification is closely associated with the occurrence, development, progression and prognosis of cancer, and aberrant m6A regulators have been identified as novel anticancer drug targets.
Li-Juan Deng, Wei-Qing Deng, Shu-Ran Fan, Min-Feng Chen, Ming Qi, Wen-Yu Lyu, Qi Qi, Amit K. Tiwari, Jia-Xu Chen, Dong-Mei Zhang, Zhe-Sheng Chen   +10 more
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Identification of genes modified by N6-methyladenosine in patients with colorectal cancer recurrence

Frontiers in Genetics, 2022
Background: Recent studies demonstrate that N6-methyladenosine (m6A) methylation plays a crucial role in colorectal cancer (CRC). Therefore, we conducted a comprehensive analysis to assess the m6A modification patterns and identify m6A-modified genes in ...
Qianru Zhu, Qianru Zhu, Qianru Zhu, Qianru Zhu, Xingxing Huang, Xingxing Huang, Xingxing Huang, Xingxing Huang, Shuxian Yu, Shuxian Yu, Shuxian Yu, Lan Shou, Lan Shou, Lan Shou, Ruonan Zhang, Ruonan Zhang, Ruonan Zhang, Ruonan Zhang, Han Xie, Han Xie, Han Xie, Zimao Liang, Zimao Liang, Zimao Liang, Zimao Liang, Xueni Sun, Xueni Sun, Xueni Sun, Jiao Feng, Jiao Feng, Jiao Feng, Ting Duan, Ting Duan, Ting Duan, Mingming Zhang, Mingming Zhang, Mingming Zhang, Yu Xiang, Yu Xiang, Yu Xiang, Xinbing Sui, Xinbing Sui, Xinbing Sui, Xinbing Sui, Xinbing Sui, Xinbing Sui, Weiwei Jin, Weiwei Jin, Lili Yu, Qibiao Wu, Qibiao Wu, Qibiao Wu, Qibiao Wu   +52 more
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