Results 31 to 40 of about 836,621 (308)

m6A-Driver: Identifying Context-Specific mRNA m6A Methylation-Driven Gene Interaction Networks. [PDF]

, 2016
As the most prevalent mammalian mRNA epigenetic modification, N6-methyladenosine (m6A) has been shown to possess important post-transcriptional regulatory functions.
Meng, Jia, Lian Liu, Zhang, Shao-Wu, Shao-Wu Zhang (2901425), Song-Yao Zhang, Liu, Lian, Huang, Yufei, Shao-Wu Zhang, Yufei Huang (195878), Song-Yao Zhang (3708619), Lian Liu (371908), Zhang, Song-Yao, Jia Meng (306948), Jia Meng, Yufei Huang   +14 more
core   +1 more source

The functions of N6-methyladenosine modification in lncRNAs

Genes and Diseases, 2020
Increasing evidence indicates that mRNAs are often subject to posttranscriptional modifications. Among them, N6-methyladenosine (m6A), which has been shown to play key roles in RNA splicing, stability, nuclear export, and translation, is the most ...
Rong-Zhang He, Jing Jiang, Di-Xian Luo
doaj   +1 more source

m6A Methylation in Cardiovascular Diseases: From Mechanisms to Therapeutic Potential

Frontiers in Genetics, 2022
Cardiovascular disease (CVD) is a leading cause of morbidity and mortality worldwide. Recent studies have shown that n6-methyladenosine (m6A) plays a major role in cardiovascular homeostasis and pathophysiology.
Longbo Li, Nannan Xu, Jia Liu, Zhenzhen Chen, Xu Liu, Junnan Wang   +5 more
doaj   +1 more source

The role of the Xist 5' m6A region and RBM15 in X chromosome inactivation [PDF]

, 2020
International audienceBackground: X chromosome inactivation in mammals is regulated by the non-coding (nc) RNA, Xist, which represses the chromosome from which it is transcribed.
Brockdorff, Neil, Mohammed, Shabaz, Moindrot, Benoit, Nesterova, Tatyana, Wei, Guifeng, Coker, Heather   +5 more
core   +1 more source

Characterization of the m6A regulator-mediated methylation modification patterns in oral squamous cell carcinoma

Scientific Reports, 2023
N 6-methyladenosine (m6A) is a form of posttranscriptional modification that plays important roles in cancer including oral squamous cell carcinoma (OSCC).
Lu Pan, He She, Keyi Wang, Wenhui Xia, Haonan Tang, Yuan Fan, Jinhai Ye   +6 more
doaj   +1 more source

tmatheny/m6a: Limited effects of m6A modification on mRNA partitioning into stress granules

, 2022
This code is supporting information used to generate figure for "Limited effects of m6A modification on mRNA partitioning into stress granules" (Khong et. al 2021)
tmatheny
core   +1 more source

The Emerging Role of m6A Modification in Endocrine Cancer

Cancers, 2023
With the development of RNA modification research, N6-methyladenosine (m6A) is regarded as one of the most important internal epigenetic modifications of eukaryotic mRNA. It is also regulated by methylase, demethylase, and protein preferentially recognizing the m6A modification.
Ji, Xiaoyu, Wang, Zhiyuan, Sun, Wei, Zhang, Hao   +3 more
openaire   +2 more sources

The Potential Roles of RNA N6-Methyladenosine in Urological Tumors

Frontiers in Cell and Developmental Biology, 2020
N6-methyladenosine (m6A) is regarded as the most abundant, prevalent and conserved internal mRNA modification in mammalian cells. M6A can be catalyzed by m6A methyltransferases METTL3, METTL14 and WTAP (writers), reverted by demethylases ALKBH5 and FTO ...
Yang Li, Yu-zheng Ge, Luwei Xu, Zheng Xu, Quanliang Dou, Ruipeng Jia   +5 more
doaj   +1 more source

The mRNA m6A reader YTHDF2 supresses pro-inflammatory pathways and sustains hematopoietic stem cell function [PDF]

, 2020
The mRNA N6-methyladenosine (m6A) modification has emerged as an essential regulator of normal and malignant hematopoiesis. Inactivation of the m6A mRNA reader YTHDF2, which recognizes m6A-modified transcripts to promote m6A-mRNA degradation, results in ...
Joana Campos, O’Carroll, Dónal, Sarapuu, Annika, Daniela S. Krause, Choe, Junho, Ivayla Ivanova, Marcos Morgan, Campos, Joana, Krause, Daniela S, David Wotherspoon, Hannah Lawson, Louie N. van de Lagemaat, Mead, Adam J., Mead, Adam J, Kranc, Kamil R, Lawson, Hannah, Morgan, Marcos, Van De Lagemaat, Louie, Alex von Kriegsheim, Mapperley, Christopher, Jasmin Paris, Kamil R. Kranc, Kriegsheim, Alex von, Ivanova, Ivayla, Dónal O’Carroll, Lagemaat, Louie N. van de, Wotherspoon, David, Gregory, Richard I., Junho Choe, Kranc, K, Jozef Durko, Much, Christian, Andrea Tavosanis, Kranc, Kamil R., van de Lagemaat, Louie N, Krause, Daniela S., Richard I. Gregory, Durko, Jozef, Adam J. Mead, von Kriegsheim, Alex, O'Carroll, Donal, Tavosanis, Andrea, Paris, Jasmin, Christian Much, Annika Sarapuu, von Kriegsheim, Alexander, Kranc, Kamil, Gregory, Richard I, Christopher Mapperley   +48 more
core   +1 more source

Characterization of immune microenvironment infiltration and m6A regulator-mediated RNA methylation modification patterns in osteoarthritis

Frontiers in Immunology, 2022
BackgroundFew studies have been reported the potential role of N6-methyladenosine (m6A) modification in osteoarthritis (OA). We investigated the patterns of m6A modification in the immune microenvironment of OA.MethodsWe evaluated the m6A modification ...
Yulong Ouyang, Yuanqing Tu, Shuilin Chen, Huan Min, Zhexu Wen, Guihao Zheng, Ting Wan, Hao Fan, Wenzhao Yang, Guicai Sun   +9 more
doaj   +1 more source