Results 11 to 20 of about 836,621 (308)

Link Between m6A Modification and Cancers [PDF]

Frontiers in Bioengineering and Biotechnology, 2018
N6-methyladenosine (m6A) epitranscriptional modification has recently gained much attention. Through the development of m6A sequencing, the molecular mechanism and importance of m6A have been revealed.
Zhen-Xian Liu, Li-Man Li, Hui-Lung Sun, Song-Mei Liu   +3 more
doaj   +4 more sources

N6-Methyladenosine modification: a novel pharmacological target for anti-cancer drug development

Acta Pharmaceutica Sinica B, 2018
N6-Methyladenosine (m6A) modification is the most pervasive modification of human mRNA molecules. It is reversible via regulation of m6A modification methyltransferase, demethylase and proteins that preferentially recognize m6A modification as “writers”,
Yi Niu, Arabella Wan, Ziyou Lin, Xiongbin Lu, Guohui Wan   +4 more
doaj   +2 more sources

The Role of m6A Modification and m6A Regulators in Esophageal Cancer

Cancers, 2022
N6-methyladenosine (m6A) modification, the most prevalent RNA modification, is involved in all aspects of RNA metabolism, including RNA processing, nuclear export, stability, translation and degradation.
Xi Huang, Yuekao Li, Tianyu Chen, Xiangran Huo, Na Wang, Huang, Xi, Shiru Cao, Cao, Shiru, Chen, Tianyu, Saijin Cui, Niu, Chaoxu, Rongmiao Zhou, Huo, Xiangran, Li, Yuekao, Chaoxu Niu, Zhou, Rongmiao, Wang, Na, Cui, Saijin   +17 more
core   +3 more sources

Crosstalk between m6A modification and autophagy in cancer

Cell & Bioscience
Autophagy is a cellular self-degradation process that plays a crucial role in maintaining metabolic functions in cells and organisms. Dysfunctional autophagy has been linked to various diseases, including cancer.
Tao Chen, Liying Zheng, Peiyue Luo, Jun Zou, Wei Li, Qi Chen, Junrong Zou, Biao Qian   +7 more
doaj   +3 more sources

p300-Mediated H3K18 Lactylation Drives Radiation-Induced Pulmonary Fibrosis via VIRMA-Dependent m6A Modification of GATA3. [PDF]

Adv Sci (Weinh)
Radiation triggers glycolytic reprogramming in alveolar epithelial type II cells, causing pathological lactate accumulation. This metabolic stress drives p300‐mediated H3K18 lactylation at the VIRMA promoter, activating transcription. Elevated VIRMA enriches m6A on GATA3 mRNA, which YTHDF1 stabilizes, ultimately driving epithelial–mesenchymal ...
Yi J, Wang M, Yu D, Zhao M, Wang X, Li S, Han X, Wei W, Jin S.   +8 more
europepmc   +2 more sources

The role of m6A modification in the biological functions and diseases [PDF]

Signal Transduction and Targeted Therapy, 2021
AbstractN6-methyladenosine (m6A) is the most prevalent, abundant and conserved internal cotranscriptional modification in eukaryotic RNAs, especially within higher eukaryotic cells. m6A modification is modified by the m6A methyltransferases, or writers, such as METTL3/14/16, RBM15/15B, ZC3H3, VIRMA, CBLL1, WTAP, and KIAA1429, and, removed by the ...
Xiulin Jiang, Baiyang Liu, Zhi Nie, Lincan Duan, Qiuxia Xiong, Zhixian Jin, Cuiping Yang, Yongbin Chen   +7 more
openaire   +3 more sources

m6A modifications regulate intestinal immunity and rotavirus infection [PDF]

, 2022
N6-methyladenosine (m6A) is an abundant mRNA modification and affects many biological processes. However, how m6A levels are regulated during physiological or pathological processes such as virus infections, and the in vivo function of m6A in the ...
Ding, Siyuan, Hou, Gaopeng, Wang, Anmin, et al,   +3 more
core   +1 more source

mRNA modifications in cardiovascular biology and disease: with a focus on m6A modification

Cardiovascular Research, 2021
Abstract Among several known RNA modifications, N6-methyladenosine (m6A) is the most studied RNA epitranscriptomic modification and controls multiple cellular functions during development, differentiation, and disease. Current research advancements have made it possible to examine the regulatory mechanisms associated with RNA methylation
Rajesh Kumari, Prabhat Ranjan, Zainab Gbongbo Suleiman, Sumanta Kumar Goswami, Jing Li, Ram Prasad, Suresh Kumar Verma   +6 more
openaire   +2 more sources

Functional Dissection of the m6A RNA Modification [PDF]

Trends in Biochemical Sciences, 2017
Much work over the past three decades has established that chemical modifications of DNA and histones are intimately linked with various facets of DNA metabolism, most notably transcription. In addition to chromatin components, RNA has long been known to be chemically modified [1]. The N6-methyladenosine (m6A) RNA modification has recently emerged as a
Brooke, Huisman, Gabriel, Manske, Stephen, Carney, Sundeep, Kalantry   +3 more
openaire   +2 more sources

The Potential Role of m6A RNA Methylation in the Aging Process and Aging-Associated Diseases

Frontiers in Genetics, 2022
N6-methyladenosine (m6A) is the most common and conserved internal eukaryotic mRNA modification. m6A modification is a dynamic and reversible post-transcriptional regulatory modification, initiated by methylase and removed by RNA demethylase. m6A-binding
Jin Sun, Jin Sun, Bokai Cheng, Bokai Cheng, Yongkang Su, Yongkang Su, Man Li, Man Li, Shouyuan Ma, Yan Zhang, Anhang Zhang, Anhang Zhang, Shuang Cai, Shuang Cai, Qiligeer Bao, Qiligeer Bao, Shuxia Wang, Shuxia Wang, Ping Zhu, Ping Zhu   +19 more
doaj   +1 more source