Results 11 to 20 of about 23,657 (254)

Crosstalk between m6A modification and autophagy in cancer

Cell & Bioscience
Autophagy is a cellular self-degradation process that plays a crucial role in maintaining metabolic functions in cells and organisms. Dysfunctional autophagy has been linked to various diseases, including cancer.
Tao Chen, Liying Zheng, Peiyue Luo, Jun Zou, Wei Li, Qi Chen, Junrong Zou, Biao Qian   +7 more
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The role of m6A modification in the biological functions and diseases [PDF]

Signal Transduction and Targeted Therapy, 2021
AbstractN6-methyladenosine (m6A) is the most prevalent, abundant and conserved internal cotranscriptional modification in eukaryotic RNAs, especially within higher eukaryotic cells. m6A modification is modified by the m6A methyltransferases, or writers, such as METTL3/14/16, RBM15/15B, ZC3H3, VIRMA, CBLL1, WTAP, and KIAA1429, and, removed by the ...
Xiulin Jiang, Baiyang Liu, Zhi Nie, Lincan Duan, Qiuxia Xiong, Zhixian Jin, Cuiping Yang, Yongbin Chen   +7 more
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Dynamic regulation and functions of mRNA m6A modification [PDF]

Cancer Cell International, 2022
AbstractN6-Methyladenosine (m6A), the most abundant internal modification associated with eukaryotic mRNAs, has emerged as a dynamic regulatory mechanism controlling the expression of genes involved in many physiological activities by affecting various steps of mRNA metabolism, including splicing, export, translation, and stability. Here, we review the
Shanshan Wang, Wei Lv, Tao Li, Shubing Zhang, Huihui Wang, Xuemei Li, Lianzi Wang, Dongyue Ma, Yan Zang, Jilong Shen, Yuanhong Xu, Wei Wei   +11 more
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Transcriptome-wide identification of altered RNA m6A profiles in cardiac tissue of rats with LPS-induced myocardial injury

Frontiers in Immunology, 2023
PurposeMyocardial injury is a common complication in patients with endotoxaemia/sepsis, especially in children. Moreover, it develops through an unclear pathophysiological mechanism, and effective therapies are lacking.
Wei Wang, Tie-Ning Zhang, Ni Yang, Ri Wen, Yu-Jing Wang, Bing-Lun Zhang, Yu-Hang Yang, Chun-Feng Liu   +7 more
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mRNA modifications in cardiovascular biology and disease: with a focus on m6A modification

Cardiovascular Research, 2021
Abstract Among several known RNA modifications, N6-methyladenosine (m6A) is the most studied RNA epitranscriptomic modification and controls multiple cellular functions during development, differentiation, and disease. Current research advancements have made it possible to examine the regulatory mechanisms associated with RNA methylation
Rajesh Kumari, Prabhat Ranjan, Zainab Gbongbo Suleiman, Sumanta Kumar Goswami, Jing Li, Ram Prasad, Suresh Kumar Verma   +6 more
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M6A methylation modification in autoimmune diseases, a promising treatment strategy based on epigenetics

Arthritis Research & Therapy, 2023
Background N6-methyladenosine (m6A) methylation modification is involved in the regulation of various biological processes, including inflammation, antitumor, and antiviral immunity. However, the role of m6A modification in the pathogenesis of autoimmune
Yurong Huang, Qiuyun Xue, Jun Chang, Yuting Wang, Chenglong Cheng, Suowen Xu, Xiao Wang, Chenggui Miao   +7 more
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Functional Dissection of the m6A RNA Modification [PDF]

Trends in Biochemical Sciences, 2017
Much work over the past three decades has established that chemical modifications of DNA and histones are intimately linked with various facets of DNA metabolism, most notably transcription. In addition to chromatin components, RNA has long been known to be chemically modified [1]. The N6-methyladenosine (m6A) RNA modification has recently emerged as a
Brooke, Huisman, Gabriel, Manske, Stephen, Carney, Sundeep, Kalantry   +3 more
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The Role of m6A Modification and m6A Regulators in Esophageal Cancer

Cancers, 2022
N6-methyladenosine (m6A) modification, the most prevalent RNA modification, is involved in all aspects of RNA metabolism, including RNA processing, nuclear export, stability, translation and degradation. Therefore, m6A modification can participate in various physiological functions, such as tissue development, heat shock response, DNA damage response ...
Li, Yuekao, Niu, Chaoxu, Wang, Na, Huang, Xi, Cao, Shiru, Cui, Saijin, Chen, Tianyu, Huo, Xiangran, Zhou, Rongmiao   +8 more
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N6-Methyladenosine-Sculpted Regulatory Landscape of Noncoding RNA

Frontiers in Oncology, 2021
The exploration of dynamic N6-methyladenosine (m6A) RNA modification in mammalian cells has attracted great interest in recent years. M6A modification plays pivotal roles in multiple biological and pathological processes, including cellular reprogramming,
Zhongyuan Zhang, Wei Wei, Hao Wang, Jiangning Dong   +3 more
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The Potential Role of m6A RNA Methylation in the Aging Process and Aging-Associated Diseases

Frontiers in Genetics, 2022
N6-methyladenosine (m6A) is the most common and conserved internal eukaryotic mRNA modification. m6A modification is a dynamic and reversible post-transcriptional regulatory modification, initiated by methylase and removed by RNA demethylase. m6A-binding
Jin Sun, Jin Sun, Bokai Cheng, Bokai Cheng, Yongkang Su, Yongkang Su, Man Li, Man Li, Shouyuan Ma, Yan Zhang, Anhang Zhang, Anhang Zhang, Shuang Cai, Shuang Cai, Qiligeer Bao, Qiligeer Bao, Shuxia Wang, Shuxia Wang, Ping Zhu, Ping Zhu   +19 more
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