Results 11 to 20 of about 1,875,792 (320)
Dynamic regulation and functions of mRNA m6A modification [PDF]
Cancer Cell International, 2022 N 6 -Methyladenosine (m6A), the most abundant internal modification associated with eukaryotic mRNAs, has emerged as a dynamic regulatory mechanism controlling the expression of genes involved in many physiological activities by affecting various steps ...
Shanshan Wang +11 more
semanticscholar +4 more sources
Ramifications of m6A Modification on ncRNAs in Cancer
Current Genomics, 2023 N6-methyladenosine (m6A) is an RNA modification wherein the N6-position of adenosine is methylated. It is one of the most prevalent internal modifications of RNA and regulates various aspects of RNA metabolism. M6A is deposited by m6A methyltransferases,
Rashid Mehmood
semanticscholar +3 more sources
Crosstalk between m6A modification and autophagy in cancer
Cell & BioscienceAutophagy is a cellular self-degradation process that plays a crucial role in maintaining metabolic functions in cells and organisms. Dysfunctional autophagy has been linked to various diseases, including cancer.
Tao Chen +7 more
doaj +3 more sources
Frontiers in Oncology, 2022 As the most common post-transcriptional RNA modification, m6A methylation extensively regulates the structure and function of RNA. The dynamic and reversible modification of m6A is coordinated by m6A writers and erasers. m6A reader proteins recognize m6A
Xun Chen +11 more
doaj +1 more source
Frontiers in Oncology, 2021 BackgroundStudies have shown that N6-methyl adenosine (m6A) plays an important role in cancer progression; however, the underlying mechanism of m6A modification in tumor microenvironment (TME) cell infiltration of bladder cancer remains unclear.
Huili Zhu +6 more
doaj +1 more source
Research progress of m6A methylation in prostate cancer
Asian Journal of Andrology, 2023 N6-methyladenosine (m6A) is a ubiquitous RNA modification in mammals. This modification is “written” by methyltransferases and then “read” by m6A-binding proteins, followed by a series of regulation, such as alternative splicing, translation, RNA ...
Shou-Yi Zhang, Yu Zeng
doaj +1 more source
Frontiers in Oncology, 2023 N6-methyladenosine (m6A) is the most pervasive RNA modification in eukaryotic cells. The dynamic and reversible m6A modification of RNA plays a critical role in the occurrence and progression of tumors by regulating RNA metabolism, including ...
Xiaohan Jiang +7 more
doaj +1 more source
Frontiers in Immunology, 2023 PurposeMyocardial injury is a common complication in patients with endotoxaemia/sepsis, especially in children. Moreover, it develops through an unclear pathophysiological mechanism, and effective therapies are lacking.
Wei Wang +7 more
doaj +1 more source
Nanopore direct RNA sequencing maps the complexity of Arabidopsis mRNA processing and m6A modification [PDF]
, 2020 Understanding genome organization and gene regulation requires insight into RNA transcription, processing and modification. We adapted nanopore direct RNA sequencing to examine RNA from a wild-type accession of the model plant Arabidopsis thaliana and a ...
Barton, Geoffrey J. +8 more
core +3 more sources
mRNA modifications in cardiovascular biology and disease: with a focus on m6A modification
Cardiovascular Research, 2021 Abstract Among several known RNA modifications, N6-methyladenosine (m6A) is the most studied RNA epitranscriptomic modification and controls multiple cellular functions during development, differentiation, and disease. Current research advancements have made it possible to examine the regulatory mechanisms associated with RNA methylation
Rajesh Kumari +6 more
openaire +2 more sources