Results 41 to 50 of about 836,621 (308)

The 18S ribosomal RNA m6A methyltransferase Mettl5 is required for normal walking behavior in Drosophila

, 2020
RNA modifications have recently emerged as an important layer of gene regulation. N6-methyladenosine (m6A) is the most prominent modification on eukaryotic messenger RNA and has also been found on noncoding RNA, including ribosomal and small nuclear RNA.
Jessica Leismann, Graille, Marc, Jean‐Yves Roignant, Ludivine Wacheul, Marc Graille, Mier, Pablo, Spagnuolo, Mariangela, Niehrs, Christof, Mariangela Spagnuolo, Roignant, Jean‐yves, Mihika Pradhan, Pablo Mier, Denis LJ Lafontaine, Roignant, Jean-Yves, Christof Niehrs, Miguel A Andrade‐Navarro, Michael Musheev, Leismann, Jessica, Vu, Minh Anh, Lafontaine, Denis Lj, Pradhan, Mihika, Wacheul, Ludivine, Andrade‐navarro, Miguel, Minh Anh Vu, Lafontaine, Denis, Andrade-Navarro, Miguel Angel, Musheev, Michael, Andrade‐Navarro, Miguel A, Roignant, J.Y., Lafontaine, D.L., Musheev, M., Andrade-Navarro, M.A., Wacheul, L., Pradhan, M., Leismann, J., Mier, P., Spagnuolo, M., Vu, M.A., Graille, M., Niehrs, C.   +39 more
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The m6A‑methylase complex and mRNA export [PDF]

, 2019
During synthesis, mRNA undergoes a number of modifications such as capping, splicing and polyadenylation. These processes are coupled with the orderly deposition of the TREX complex on the mRNA and subsequent recruitment of the NXF1-P15 heterodimer which
Wilson, S.A., Lesbirel, S.
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The Tudor SND1 protein is an m6A RNA reader essential for replication of Kaposi’s sarcoma-associated herpesvirus [PDF]

, 2019
N6-methyladenosine (m6A) is the most abundant internal RNA modification of cellular mRNAs. m6A is recognised by YTH domain-containing proteins, which selectively bind to m6A-decorated RNAs regulating their turnover and translation.
Wilson, S.A., Adrian Whitehouse, Whitehouse, A., Wilson, SA, Belinda Baquero-Perez, Wilson, Stuart A., Whitehouse, A, Baquero Pérez, Belinda, Antanaviciute, A., Whitehouse, Adrian, Ian M Carr, Yonchev, I.D., Stuart A Wilson, Agne Antanaviciute, Baquero-Perez, B., Antanaviciute, A, Carr, I.M., Yonchev, ID, Carr, Ian M., Carr, IM, Ivaylo D Yonchev, Yonchev, Ivaylo D., Baquero-Perez, B, Antanaviciute, Agne   +23 more
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The current landscape of m6A modification in urological cancers

PeerJ, 2023
N6-methyladenosine (m6A) methylation is a dynamic and reversible procession of epigenetic modifications. It is increasingly recognized that m6A modification has been involved in the tumorigenesis, development, and progression of urological tumors. Emerging research explored the role of m6A modification in urological cancer.
Zeng, Yaohui, Lv, Cai, Wan, Bangbei, Gong, Binghao   +3 more
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The Role of m6A Ribonucleic Acid Modification in the Occurrence of Atherosclerosis

Frontiers in Genetics, 2021
The N6-methyladenosine (m6A) modification is the most abundant epitranscriptomic modification in eukaryotic messenger RNA (mRNA). The m6A modification process is jointly regulated by various enzymes and proteins, such as methyltransferases, demethylases ...
Jie Fu, Jie Fu, Xinghui Cui, Xinghui Cui, Xiaoyun Zhang, Min Cheng, Xiaoxia Li, Zhiliang Guo, Xiaodong Cui   +8 more
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Current insights into the implications of m6A RNA methylation and autophagy interaction in human diseases

Cell & Bioscience, 2021
Autophagy is a conserved degradation process crucial to maintaining the primary function of cellular and organismal metabolism. Impaired autophagy could develop numerous diseases, including cancer, cardiomyopathy, neurodegenerative disorders, and aging ...
Xuechai Chen, Jianan Wang, Muhammad Tahir, Fangfang Zhang, Yuanyuan Ran, Zongjian Liu, Juan Wang   +6 more
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Structural Insights into N6-methyladenosine (m6A) Modification in the Transcriptome

Genomics, Proteomics & Bioinformatics, 2018
More than 100 types of chemical modifications in RNA have been well documented. Recently, several modifications, such as N6-methyladenosine (m6A), have been detected in mRNA, opening the window into the realm of epitranscriptomics.
Jinbo Huang, Ping Yin
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Identification of New m6A Methylation Modification Patterns and Tumor Microenvironment Infiltration Landscape that Predict Clinical Outcomes for Papillary Renal Cell Carcinoma Patients

Frontiers in Cell and Developmental Biology, 2022
N6-methyladenosine (m6A) is the product of the most prevalent mRNA modification in eukaryotic cells. Accumulating evidence shows that tumor microenvironment (TME) plays a pivotal role in tumor development. However, the underlying relationship between m6A
Bin Zheng, Bin Zheng, Bin Zheng, Fajuan Cheng, Fajuan Cheng, Zhongshun Yao, Zhongshun Yao, Yiming Zhang, Yiming Zhang, Zixiang Cong, Zixiang Cong, Zixiang Cong, Jianwei Wang, Zhihong Niu, Zhihong Niu, Wei He, Wei He   +16 more
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The m6A-methylase complex recruits TREX and regulates mRNA export [PDF]

, 2018
N6-methyladenosine (m6A) is the most abundant internal modification of eukaryotic mRNA. This modification has previously been shown to alter the export kinetics for mRNAs though the molecular details surrounding this phenomenon remain poorly understood ...
Wilson, S.A., Heath, C., Sudbery, I., Viphakone, N., Parker, J., Parker, M., Lesbirel, S.   +6 more
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m6A modification: recent advances, anticancer targeted drug discovery and beyond

Molecular Cancer, 2022
Abnormal N6-methyladenosine (m6A) modification is closely associated with the occurrence, development, progression and prognosis of cancer, and aberrant m6A regulators have been identified as novel anticancer drug targets.
Li-Juan Deng, Wei-Qing Deng, Shu-Ran Fan, Min-Feng Chen, Ming Qi, Wen-Yu Lyu, Qi Qi, Amit K. Tiwari, Jia-Xu Chen, Dong-Mei Zhang, Zhe-Sheng Chen   +10 more
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