Results 61 to 70 of about 836,621 (308)

The human 18S rRNA m6A methyltransferase METTL5 is stabilized by TRMT112

, 2019
International audienceN6-methyladenosine (m6A) has recently been found abundantly on messenger RNA and shown to regulate most steps of mRNA metabolism.
Hackert, Philipp, Bohnsack, Katherine, Graille, Marc, Ernst, Felix, Bohnsack, Katherine K.E., Zorbas, Christiane, Hawley, Ben R, Hawley, Ben B.R., Bohnsack, Markus, Jaffrey, Samie, Ulryck, Nathalie, Hawley, Ben, Lafontaine, Denis, Bohnsack, Katherine E, Jaffrey, Samie R, Bohnsack, Markus T, Jaffrey, Samie S.R., Bohnsack, Markus M.T., Lafontaine, Denis L j, Van tran, Nhan, Ernst, Felix G m   +20 more
core   +1 more source

CRISPR-based m6A modification and its potential applications in telomerase regulation

Frontiers in Cell and Developmental Biology, 2023
Telomerase determines cell lifespan by controlling chromosome stability and cell viability, m6A epigenetic modification plays an important role in the regulation of telomerase activity.
Mingliang Yi, Mingyue Wang, Yongjie Xu, Zhikun Cao, Yinghui Ling, Yinghui Ling, Zijun Zhang, Zijun Zhang, Hongguo Cao, Hongguo Cao   +9 more
doaj   +1 more source

N6-methyladenosine-dependent RNA Structural Switches Modulate RNA-protein Interactions [PDF]

, 2015
Various chemical modifications have been found in cellular RNAs, but their functions remain an uncharted territory. N6 -methyladenosine (m6A), the most abundant and dynamic internal modification in eukaryotic messenger RNA (mRNAs), is indispensable for ...
Liu, Nian
core   +1 more source

Uncovering G Protein‐Coupled Receptors: Novel Targets and Biomarkers for Predicting Glioma Prognosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Low‐grade gliomas (LGG) exhibit significant heterogeneity and recurrence risk. G protein‐coupled receptors (GPCR) contribute to glioma malignant progression, but their prognostic value remains unclear. This work attempts to formulate a GPCR‐based outcome‐predicting model for LGG. Methods Based on TCGA LGG data, the enrichment scores
Jun Yang, Dongxu Zhang, Dongyuan Liu, Da Lin, Hao Wang   +4 more
wiley   +1 more source

The m6A Methyltransferase METTL3 Is Functionally Implicated in DLBCL Development by Regulating m6A Modification in PEDF [PDF]

Frontiers in Genetics, 2020
Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of lymphoma, whose treatment still has a major challenge of achieving a satisfactory curative effect. The underlying mechanisms also have not been fully illustrated. N 6-Methyladenosine (m6A) has been identified as the most prevalent internal modification of mRNAs present in eukaryotes ...
Yingying Cheng, Yuanyuan Fu, Ying Wang, Jinbi Wang   +3 more
openaire   +3 more sources

RNA m6A Modification in Cancers: Molecular Mechanisms and Potential Clinical Applications

The Innovation, 2020
N6-Methyladenosine (m6A) RNA modification brings a new dawn for RNA modification researches in recent years. This posttranscriptional RNA modification is dynamic and reversible, and is regulated by methylases (“writers”), demethylases (“erasers”), and ...
Chang Gu, Xin Shi, Chenyang Dai, Feng Shen, Gaetano Rocco, Jiafei Chen, Zhengyu Huang, Chunji Chen, Chuan He, Tao Huang, Chang Chen   +10 more
doaj   +1 more source

From A to m⁶A: The Emerging Viral Epitranscriptome

, 2021
There are over 100 different chemical RNA modifications, collectively known as the epitranscriptome. N6-methyladenosine (m6A) is the most commonly found internal RNA modification in cellular mRNAs where it plays important roles in the regulation of the ...
Belinda Baquero-Perez, Díez Antón, Juana, 1962-, Juana Díez, Baquero Pérez, Belinda, Geers, Daryl, Daryl Geers   +5 more
core   +1 more source

BAP31 Drives Cartilage Calcification through Disruption of Autophagosome–Lysosome Fusion in Osteoarthritis

Advanced Science, EarlyView.
Mechanical stress activates BAP31 in chondrocytes. BAP31 competes with ATG14 for binding to STX17, disrupting the STX17–ATG14 complex required for autophagosome–lysosome fusion. The resultant autophagic flux blockade drives the generation of autophagy‐derived exosomes, which mediate pathological cartilage calcification in OA. Chondrocyte‐targeted BAP31
Zhi‐hua Xu, Ruo‐xin Wang, Feng He, Qian Liu, Fu‐yin Li, Min Hui, Yu‐qian Shi, Yu Jiang, Qing‐hua Li, Jun‐wen Jing, Shi‐bin Yu, Li‐tian Ma, Qian‐nan Niu, Mian Zhang   +13 more
wiley   +1 more source

Multidimensional and Multifunctional Laser‐Induced Graphene (LIG) for Point‐of‐Care and Wearable Biosensing, Theranostics, and Bioactive Interfaces Toward Personalized Healthcare and Regenerative Medicine

Advanced Science, EarlyView.
Multidimensional laser‐induced graphene (LIG) spanning from 0D to 3D architectures is comprehensively reviewed for multifunctional biomedical platforms, including biosensing, theranostics, and bioactive interface applications, which highlights its potentials for point‐of‐care diagnostics, wearable health monitoring, smart drug delivery, and tissue ...
Li Zhang, Yurou Yuan, Xiaohong Ding, Wing Cheung Mak   +3 more
wiley   +1 more source

Identification of factors required for m6A mRNA methylation in Arabidopsis reveals a role for the conserved E3 ubiquitin ligase HAKAI [PDF]

, 2017
N6-adenosine methylation (m6A) of mRNA is an essential process in most eukaryotes, but its role and the status of factors accompanying this modification are still poorly understood. Using combined methods of genetics, proteomics and RNA biochemistry,
Mi Zhang, Geert De Jaeger, Dominique Eeckhout, Li, Hongying, Nigel P. Mongan, Zhang, Mi, Fray, Rupert G, Helariutta, Yk�, Bodi, Zsuzsanna, Helariutta, Yrjö Eero, Campilho, Ana, Jan Hejátko, Hongying Li, Ykä Helariutta, Mária Saleh, Hejátko, Jan, Zsuzsanna Bodi, De Jaeger, Geert, Mongan, Nigel P, Kamil Růžička, Zhong, Silin, Saleh, Mária, Jaeger, Geert De, Hej�tko, Jan, Helariutta, Ykä, Rupert G. Fray, Eeckhout, Dominique, Mongan, Nigel P., R?�i?ka, Kamil, Fray, Rupert G., El Showk, Sedeer Nabil, Silin Zhong, Kashif, Muhammad, Saleh, M�ria, Muhammad Kashif, El-Showk, Sedeer, Růžička, Kamil, Sedeer El‐Showk, Ana Campilho   +38 more
core   +3 more sources