FTO Demethylates Cyclin D1 mRNA and Controls Cell-Cycle Progression
Cell Reports, 2020 Summary: N6-Methyladenosine (m6A) modification is the major chemical modification in mRNA that controls fundamental biological processes, including cell proliferation.
Mayumi Hirayama +10 more
doaj +1 more source
Identification of genes modified by N6-methyladenosine in patients with colorectal cancer recurrence
Frontiers in Genetics, 2022 Background: Recent studies demonstrate that N6-methyladenosine (m6A) methylation plays a crucial role in colorectal cancer (CRC). Therefore, we conducted a comprehensive analysis to assess the m6A modification patterns and identify m6A-modified genes in ...
Qianru Zhu +52 more
doaj +1 more source
Yeast m6 A methylated mRNAs are enriched on translating ribosomes during meiosis, and under rapamycin treatment [PDF]
, 2015 Interest in mRNA methylation has exploded in recent years. The sudden interest in a 40 year old discovery was due in part to the finding of FTO’s (Fat Mass Obesity) N6-methyladenosine (m6 A) deaminase activity, thus suggesting a link between obesity ...
Archer, Nathan +5 more
core +3 more sources
m6A modification in inflammatory bowel disease provides new insights into clinical applications.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2023 Inflammatory bowel disease (IBD) results from a complex interplay between genetic predisposition, environmental factors, and gut microbes. The role of N6-methyladenosine (m6A) methylation in the pathogenesis of IBD has attracted increasing attention. m6A
Jiamin Zhang +6 more
semanticscholar +1 more source
The how and why of lncRNA function: An innate immune perspective. [PDF]
, 2020 Next-generation sequencing has provided a more complete picture of the composition of the human transcriptome indicating that much of the "blueprint" is a vastness of poorly understood non-protein-coding transcripts.
Carpenter, Susan +2 more
core
$\kappa$-Deformations and Extended $\kappa$-Minkowski Spacetimes [PDF]
, 2014 We extend our previous study of Hopf-algebraic $\kappa$-deformations of all inhomogeneous orthogonal Lie algebras ${\rm iso}(g)$ as written in a tensorial and unified form.
Borowiec, Andrzej, Pachol, Anna
core +4 more sources
Crystal structure and mechanism of action of the N6-methyladenine-dependent type IIM restriction endonuclease R.DpnI. [PDF]
, 2012 DNA methylation-dependent restriction enzymes have many applications in genetic engineering and in the analysis of the epigenetic state of eukaryotic genomes.
Bochtler, Matthias +4 more
core +1 more source
Characterization of m6A methylation modifications in gastric cancer
Aging, 2023 Widely recognized as an essential epitranscriptomic modification, RNA N6-methyladenosine (m6A) is involved in both physiological and pathological processes. Here, we want to investigate m6A modification's potential roles in gastric cancer. Gastric cancer samples were selected from TCGA-STAD and GEO (GSE84426, GSE84433) datasets.
Yin, Wei +5 more
openaire +2 more sources
The role of m6A modification in physiology and disease [PDF]
Cell Death & Disease, 2020 AbstractSimilar to DNA epigenetic modifications, multiple reversible chemical modifications on RNAs have been uncovered in a new layer of epigenetic modification. N6-methyladenosine (m6A), a modification that occurs in ~30% transcripts, is dynamically regulated by writer complex (methylase) and eraser (RNA demethylase) proteins, and is recognized by ...
Yang, Chuan +8 more
openaire +2 more sources
Frontiers in Plant ScienceThe epitranscriptomic mark N6-methyladenosine (m6A) is the most common type of messenger RNA (mRNA) post-transcriptional modification in eukaryotes. With the discovery of the demethylase FTO (FAT MASS AND OBESITY-ASSOCIATED PROTEIN) in Homo Sapiens, this
Yang Xiang +8 more
doaj +1 more source