Results 81 to 90 of about 1,875,792 (320)

TRMT6‐Mediated m1A Modification of CDK9 mRNA Is a Dual‐Pronged Pathogenic Driver for HBV‐Related Hepatocellular Carcinoma

Advanced Science, EarlyView.
TRMT6‐mediated m1A modification in CDK9 mRNA enhances its mRNA stability and translation efficiency, thereby increasing the protein levels of CDK9. Upregulated CDK9 promotes the progression of HCC by elevating the levels of oncogenic factors including p‐STAT3, MCL1, and BCL‐2. On the other hand, CDK9 phosphorylates TARDBP at Ser254 to activate HBV core
Rui Zhang, Dandan Zong, Rui Liu, Yubo Wang, Qingqing Gu, Yao Yao, Wenfang Zheng, Mengmeng Yuan, Simeng Wang, Rongrong Cui, Daxu Li, Siwen Dang, Peng Hou   +12 more
wiley   +1 more source

CRISPR-based m6A modification and its potential applications in telomerase regulation

Frontiers in Cell and Developmental Biology, 2023
Telomerase determines cell lifespan by controlling chromosome stability and cell viability, m6A epigenetic modification plays an important role in the regulation of telomerase activity.
Mingliang Yi, Mingyue Wang, Yongjie Xu, Zhikun Cao, Yinghui Ling, Yinghui Ling, Zijun Zhang, Zijun Zhang, Hongguo Cao, Hongguo Cao   +9 more
doaj   +1 more source

Transcriptome-wide high-throughput deep m6A-seq reveals unique differential m6A methylation patterns between three organs in Arabidopsis thaliana [PDF]

, 2015
Proportion of two types of m6A distributing feature in mRNA.
Dayong Zhang, Kai Tang, Shaojun Xie, Xiaohong Zhu, Yizhen Wan, Zegang Wang, Zhaobo Lang   +6 more
core   +11 more sources

NAT10 mediated ac4C acetylation driven m6A modification via involvement of YTHDC1-LDHA/PFKM regulates glycolysis and promotes osteosarcoma

Cell Communication and Signaling
The dynamic changes of RNA N6-methyladenosine (m6A) during cancer progression participate in various cellular processes. However, less is known about a possible direct connection between upstream regulator and m6A modification, and therefore affects ...
Zhongting Mei, Zhihua Shen, Jiaying Pu, Qian Liu, Guoxin Liu, Xuting He, Yang Wang, Jinrui Yue, Shiyu Ge, Tao Li, Ye Yuan, Lei Yang   +11 more
semanticscholar   +1 more source

Zinc Exposure Causes Disulfidptosis to Induce Miscarriage by Up‐Regulating GATA1/METTL1/SLC7A11 Axis

Advanced Science, EarlyView.
Zn exposure up‐regulates GATA1, promoting GATA1‐mediated METTL1 and SLC7A11 transcription. It also enhances METTL1‐mediated m7G modification on SLC7A11 mRNA, increasing SLC7A11 mRNA stability. Ultimately, Zn exposure up‐regulates SLC7A11 at both transcriptional and post‐transcriptional levels, causing disulfidptosis. Knockdown of murine Slc7a11, Gata1,
Wenxin Huang, Yi Sun, Yanxin Wang, Haijun Yan, Xiaoping Yue, Weidong Wu, Xueyu Chen, Jinfang Zhang, Yanbing Lin, Qiong Lei, Nan Ji, Shuaishuai Xing, Liqin Zeng, Qingzheng Kang, Depeng Zhao, Geng Guo, Huidong Zhang   +16 more
wiley   +1 more source

The role of m6A epigenetic modifications in tumor coding and non-coding RNA processing

Cell Communication and Signaling, 2023
Background Epigenetic modifications of RNA significantly contribute to the regulatory processes in tumors and have, thus, received considerable attention.
Tongxuan Wen, Tong Li, Yeqiu Xu, Yuanzhuang Zhang, Hai Pan, Yong Wang   +5 more
doaj   +1 more source

HSP90 inhibitors stimulate DNAJB4 protein expression through a mechanism involving N6-methyladenosine. [PDF]

, 2019
Small-molecule inhibitors for the 90-kDa heat shock protein (HSP90) have been extensively exploited in preclinical studies for the therapeutic interventions of human diseases accompanied with proteotoxic stress.
Chen, Xuemei, Dai, Xiaoxia, Li, Lin, Miao, Weili, Wang, Yinsheng, Zhao, Yonghui   +5 more
core   +1 more source

METTL3-mediated m6A modification increases Hspa1a stability to inhibit osteoblast aging

Cell Death Discovery
Senile osteoporosis is mainly caused by osteoblasts attenuation, which results in reduced bone mass and disrupted bone remodeling. Numerous studies have focused on the regulatory role of m6A modification in osteoporosis; however, most of the studies have
Yao-sheng Wang, Yi Chen, Hefang Xiao, Zhongcheng Liu, Xuening Liu, Zhi-wei Feng, Xiaoyun Sheng, Bo Peng, Xiaojun Ren, Lihu Xu, F. Teng, Zhi Yi, Yongkang Niu, Dejian Xiang, Yayi Xia, Bin Geng   +15 more
semanticscholar   +1 more source

Fusobacterium nucleatum reduces METTL3-mediated m6A modification and contributes to colorectal cancer metastasis

Nature Communications, 2022
Microbiota-host interactions play critical roles in colorectal cancer (CRC) progression, however, the underlying mechanisms remain elusive. Here, we uncover that Fusobacterium nucleatum (F.
Shujie Chen, Lu Zhang, Mengjie Li, Ying Zhang, Meng Sun, Lingfang Wang, Jiebo Lin, Yun Cui, Qiang Chen, Chenqi Jin, Xiang Li, Boya Wang, Hao Chen, Tianhua Zhou, Liangjing Wang, Chih-Hung Hsu, W. Zhuo   +16 more
semanticscholar   +1 more source

BGN/MDK Axis in the Melanoma Tumor Microenvironment Strengthens Tumor Malignancy by Modulating Cancer Cells and Cancer‐Associated Fibroblasts Crosstalk

Advanced Science, EarlyView.
This study reveals that m6A regulators cooperatively upregulate BGN in melanoma, promoting malignancy. Within the tumor microenvironment, CAFs show highest BGN expression. The BGN/MDK axis mediates cancer‐stroma crosstalk, driving normal fibroblast (NF) activation and enhancing the pro‐tumor effect of CAFs, highlighting a promising therapeutic target ...
Hao‐ze Shi, Ming‐yang Wu, Jin‐quan Liu, Cuicui Tian, Li Ma, Xue‐mei Zhou, Ze‐Hao Sun, Zhi‐yong Xu, Run‐dong Zhang, Shan‐yuan Ye, Li‐ming Huang, Yan Wang, Jing‐shu Xiong, Wen‐bo Bu, Xian‐feng Cheng, Jian‐fang Sun, Hao Chen   +16 more
wiley   +1 more source