Results 81 to 90 of about 836,621 (308)
, 2022 Purpose: The present study was carried out to investigate the global m6A-modified RNA pattern and possible mechanisms underlying the pathogenesis of keloid.Method: In total, 14 normal skin and 14 keloid tissue samples were first collected on clinics ...
Yue-Sheng Huang (11176890) +8 more
core +1 more source
Advanced Science, EarlyView.Scheme of the KLF9/WTAP/YTHDF2/m6A/CSF1R regulatory axis in osteoclastogenesis and estrogen‐deficient osteoporosis. WTAP‐mediated m6A modification of Csf1r mRNA governs osteoclastogenesis via a YTHDF2‐mediated pathway. Pathological upregulation of KLF9 drives Wtap transcription, leading to increased m6A deposition on the 3’‐UTR of Csf1r mRNA.
Chen Shen +14 more
wiley +1 more source
Regulatory Role of N6-Methyladenosine (m6A) Modification in Osteoarthritis
Frontiers in Cell and Developmental Biology, 2022 Osteoarthritis (OA) is the most common joint disease, usually occurring in middle-aged and elderly people. However, current treatment for OA in its early stages is ineffective, and drug therapy is often ineffective in slowing the progression of the disease.
Ganggang Zhai +8 more
openaire +3 more sources
, 2021 N6-methyladenosine (m6A) RNA methylation has emerged as an important factor in various biological processes by regulating gene expression. However, the dynamic profile, function and underlying molecular mechanism of m6A modification during skeletal ...
Shuang Tao (11510260) +12 more
core +1 more source
Novel insights into the interaction between N6-methyladenosine modification and circular RNA
Molecular Therapy: Nucleic Acids, 2022 As the most prevalent type of RNA modification in eukaryotes, N6-methyladenosine (m6A) can modulate RNA fates such as processing, splicing, maturation, export, stability, translation, and degradation.
Tao Xu +6 more
doaj +1 more source
, 2021 N6-methyladenosine (m6A) RNA methylation has emerged as an important factor in various biological processes by regulating gene expression. However, the dynamic profile, function and underlying molecular mechanism of m6A modification during skeletal ...
Shuang Tao (11510260) +12 more
core +1 more source
Advanced Science, EarlyView.Proposed molecular mechanism: NSUN6 catalyzes m5C methylation on Snail mRNA to enhance its stability, leading to Snail upregulation and EMT promotion. The first‐in‐class inhibitor AL398 suppresses endometrial cancer metastasis by targeting the NSUN6‐m5C‐Snail. axis. ABSTRACT Endometrial cancer (EC) constitutes a leading gynecologic malignancy for which
Xiangzhuan Zhao +19 more
wiley +1 more source
Emerging Roles of N6-Methyladenosine on HIV-1 RNA Metabolism and Viral Replication [PDF]
, 2018 N6-methyladenosine (m6A) is the most abundant internal modification present in Eukaryotic mRNA. The functions of this chemical modification are mediated by m6A-binding proteins (m6A readers) and regulated by methyltransferases (m6A writers) and ...
Soto Rifo, Ricardo +7 more
core +1 more source
, 2021 N6-methyladenosine (m6A) RNA methylation has emerged as an important factor in various biological processes by regulating gene expression. However, the dynamic profile, function and underlying molecular mechanism of m6A modification during skeletal ...
Shuang Tao (11510260) +12 more
core +1 more source
Advanced Science, EarlyView.Sepsis disrupts immune‐cell rhythms and weakens bacterial clearance. Biomimetic nanovesicles combining erythrocyte and inflammation‐activated macrophage membranes deliver siNR1D1 to dysfunctional macrophages, restoring the NR1D1–IGF2BP2–V‐ATPase pathway, circadian regulation, phagolysosomal acidification, and antimicrobial defense.
Lang Chen +13 more
wiley +1 more source