Results 101 to 110 of about 1,875,792 (320)

Adaptive Response Enzyme AlkB Preferentially Repairs 1-Methylguanine and 3-Methylthymine Adducts in Double-Stranded DNA [PDF]

, 2018
The AlkB protein is a repair enzyme that uses an α-ketoglutarate/Fe(II)-dependent mechanism to repair alkyl DNA adducts. AlkB has been reported to repair highly susceptible substrates, such as 1-methyladenine and 3-methylcytosine, more efficiently in ss ...
Bian, Ke, Chen, Fangyi, Drennan, Catherine L., Essigmann, John M, Humulock, Zachary T., Jost, Marco, Li, Deyu, Tang, Qi, Yang, Xuedong   +8 more
core   +1 more source

Crosstalk between RNA m6A modification and epigenetic factors in plant gene regulation

Plant Communications
N6-methyladenosine (m6A) is the most abundant modification observed in eukaryotic mRNAs. Advances in transcriptome-wide m6A mapping and sequencing technologies have enabled the identification of several conserved motifs in plants, including the RRACH (R =
Jian-zhong Hu, Tao Xu, Hunseung Kang
semanticscholar   +1 more source

Effect of circular RNAs and N6-methyladenosine (m6A) modification on cancer biology.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2023
N6-methyladenosine (m6A), as the most abundant and well-known RNA modification, has been found to play an important role in cancer. Circular RNAs (circRNAs) are a class of single-stranded covalently closed RNA molecules generated by the reverse splicing ...
Gong Zhang, Junhui Hou, Chen Mei, Xia Wang, Yuan Wang, Kefeng Wang   +5 more
semanticscholar   +1 more source

Tetrastigma Hemsleyanum Polysaccharide Suppresses Triple‐Negative Breast Cancer by Disrupting the Hippo‐YAP/TEAD4‐PDIA4 Axis and Endoplasmic Reticulum Stress Adaptation

Advanced Science, EarlyView.
ABSTRACT Triple‐negative breast cancer (TNBC) exhibits addiction to chronic endoplasmic reticulum (ER) stress, which sustains an aggressive metastatic phenotype through activation of the unfolded protein response (UPR). Here, we identify a previously unrecognized “ER‐stress addiction” axis in which the Hippo pathway effector TEAD4 directly ...
Yini Shang, Wentao Si, Youxue Zhang, Jialin Liu, Huaixi Zhang, Yafei Li, Hongmeng Su, Wei Jiang, Zhishan Ding, Lihong Wang   +9 more
wiley   +1 more source

Regulation of N6-methyladenosine (m6A) RNA methylation in microglia-mediated inflammation and ischemic stroke

Frontiers in Cellular Neuroscience, 2022
N6-methyladenosine (m6A) is the most abundant post-transcription modification, widely occurring in eukaryotic mRNA and non-coding RNA. m6A modification is highly enriched in the mammalian brain and is associated with neurological diseases like Alzheimer ...
Fangfang Zhang, Yuanyuan Ran, Muhammad Tahir, Zihan Li, Jianan Wang, Xuechai Chen   +5 more
doaj   +1 more source

Genome-wide Maps of Nuclear Lamina Interactions in Single Human Cells [PDF]

, 2017
Mammalian interphase chromosomes interact with the nuclear lamina (NL) through hundreds of large lamina-associated domains (LADs). We report a method to map NL contacts genome-wide in single human cells.
Amendola, Mario, Bienko, Magda, Dekker, Job, Dey, Siddharth S., de Graaf, Carolyn A., de Vries, Sandra S., Fudenberg, Geoffrey, Imakaev, Maksim Viktorovich, Jalink, Kees, Kind, Jop, Lajoie, Bryan, Mirny, Leonid A, Nahidiazar, Leila, Pagie, Ludo, van Oudenaarden, Alexander, van Steensel, Bas, Zhan, Ye   +16 more
core   +1 more source

ALKBH5-mediated m6A modification of circCCDC134 facilitates cervical cancer metastasis by enhancing HIF1A transcription

Journal of experimental & clinical cancer research : CR, 2022
Metastasis is the main cause of mortality in cervical cancer (CC). Circular RNAs (circRNAs) have been demonstrated to play a crucial role in carcinoma biology.
L. Liang, Yunshu Zhu, Jian Li, Jia Zeng, Ling-Yu Wu   +4 more
semanticscholar   +1 more source

Regulatory Role of N6-Methyladenosine (m6A) Modification in Osteoarthritis

Frontiers in Cell and Developmental Biology, 2022
Osteoarthritis (OA) is the most common joint disease, usually occurring in middle-aged and elderly people. However, current treatment for OA in its early stages is ineffective, and drug therapy is often ineffective in slowing the progression of the disease.
Ganggang Zhai, Likang Xiao, Chenyang Jiang, Songkai Yue, Meng Zhang, Jia zheng, Zeming Liu, Yonghui Dong, Yonghui Dong   +8 more
openaire   +3 more sources

SMAD4 Palmitoylation Drives a Metabolic‐Transcriptional Circuit to Promote Tumorigenesis and Confers Radiosensitivity in Pancreatic Cancer

Advanced Science, EarlyView.
This study identifies palmitoylation as a novel regulatory modification of SMAD4, mediated by ZDHHC22/APT2. It activates fatty acid synthesis, creating a self‐reinforcing SMAD4–FASN–palmitate feedback loop that drives pancreatic cancer growth and enhances radiotherapy sensitivity.
Yang Wang, Shan Zhang, Junping Bai, Xiaobing Li, Yi Han, Min Ji, Chongyi Jiang, Xiaobei Ge, Tianyu Yu, Yongying Hou, Jun Zhang, Wangting Li, Yiran Song, Jiaying Cai, Yingqun Zhou, Liwei An, Feng Wang   +16 more
wiley   +1 more source

The Reverse Transcription Signature of N-\u3csub\u3e1\u3c/sub\u3e-Methyladenosine in RNA-Seq is Sequence Dependent [PDF]

, 2015
The combination of Reverse Transcription (RT) and high-throughput sequencing has emerged as a powerful combination to detect modified nucleotides in RNA via analysis of either abortive RT-products or of the incorporation of mismatched dNTPs into cDNA ...
Alfonzo, Juan, Anderson, James T., Entian, Karl-dieter, Hauenschild, Ralf, Helm, Mark, Hildebrandt, Andreas, Jaschke, Andres, Lafontaine, Denis L.J., Motorin, Yuri, Schmid, Katharina, Sharma, Sunny, Thuring, Kathrin, Tserovski, Lyudmil, Wacheul, Ludvine, Winz, Marie-Luise   +14 more
core   +1 more source