Results 101 to 110 of about 836,621 (308)

Principles of mRNA targeting via the Arabidopsis m6A-binding protein ECT2

, 2021
Arribas-Hernández L, Rennie S, Köster T, et al. Principles of mRNA targeting via the Arabidopsis m6A-binding protein ECT2. eLife. 2021;10: e72375.Specific recognition ofN6-methyladenosine (m6A) in mRNA by RNA-binding proteins containing a YT521-B ...
Peter Brodersen, Carlotta Porcelli, Köster, Tino ; https://orcid.org/, Porcelli, Carlotta, Lewinski, Martin, Arribas-Hernández, Laura, Staiger, Dorothee, Köster, Tino, Sarah Rennie, Laura Arribas-Hernández, Brodersen, Peter, Tino Köster, Martin Lewinski, Dorothee Staiger, Robin Andersson, Rennie, Sarah, Andersson, Robin   +16 more
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YTHDC1 Orchestrates Glucose and Glutamate Rewiring to Overcome Lethal Metabolic Stress in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Lai et al. find that m6A reader YTHDC1 is specifically overexpressed in triple‐negative breast cancer (TNBC) and orchestrates glucose and glutamine metabolism in an m6A‐dependent manner to confer robust adaptability to lethal metabolic stress. Leveraging YTHDC1 knockdown‐induced metabolic vulnerability, an ATF4 mRNA‐targeted nanotherapy is developed to
Zheng‐Hao Lai, Yi Wang, Na‐Na Li, Ling Zeng, Renzhong Liu, Xue Li, Cheukfai Li, Xin‐Yu Ma, Wenkui Fu, Yingsen Tang, Jinjin Chen, Ning Liao, Man‐Li Luo   +12 more
wiley   +1 more source

N6-methyladenosine regulates the stability of RNA:DNA hybrids in human cells [PDF]

, 2019
R-loops are nucleic acid structures formed by an RNA:DNA hybrid and unpaired single-stranded DNA that represent a source of genomic instability in mammalian cells1,2,3,4.
Foster, JM, Giles, TC, Garcia-Perez, JL, Natalia Gromak, Dalhus, B, Daniel Gackowski, Cristini, Agnese, Gackowski, D, Nan Dai, Rubio-Roldan, Alejandro, Ruzov, Alexey, Ivan R. Corrêa, Denning, C, Eleftheriou, Maria, Lorraine Young, Maria Eleftheriou, Rubio-Roldan, A, Corr�a, Ivan R., Daniel J. Gaffney, Dalhus, Bj�rn, Jose L. Garcia-Perez, Foster, Jeremy M., Dalhus, Bjørn, Agnese Cristini, Denning, Chris, Jeremy M. Foster, Gaffney, Daniel J., Flatt, L, Dai, Nan, Li, Miaomiao, Crutchley, James, Bjørn Dalhus, Ruzov, A, Flatt, Luke, Tom C. Giles, Giles, Tom C, Miaomiao Li, Eleftheriou, M, Cristini, A, Li, M, Giles, Tom C., Starczak, M, Gaffney, Daniel J, Corrêa, IR, Foster, Jeremy M, Garcia-Perez, Jose L., Gromak, Natalia, James Crutchley, Klungland, Arne, Alexey Ruzov, Alejandro Rubio-Roldan, Abakir, A, Emes, Richard D., Gackowski, Daniel, Crutchley, J, Arne Klungland, Young, L, Gaffney, DJ, Marta Starczak, Emes, RD, Garcia-Perez, Jose L, Young, Lorraine, Chris Denning, Klungland, A, Abdulkadir Abakir, Luke Flatt, Emes, Richard D, Corrêa, Ivan R, Abakir, Abdulkadir, Starczak, Marta, Richard D. Emes, Dai, N   +71 more
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Glucose and Glutamine Deprivation Promotes Breast Cancer Lung Metastasis via BRD4‐Dependent Enhancer Activation

Advanced Science, EarlyView.
To model a nutrient‐restricted tumor microenvironment, breast cancer cells were adapted to low glucose and glutamine levels. In the adapted cells, BRD4‐driven enhancer activation increases pro‐invasive EDN1 expression, facilitated by ATF3/c‐JUN and reinforced by enhancer RNA.
Poshan Yugal Bhattarai, Arathy Vasukutty, Yujin Na, Sung‐Chul Lim, Hong Seok Choi   +4 more
wiley   +1 more source

Unraveling the function of m6A modification in acute myeloid leukemia

, 2016
N6-methyladenosine (m6A) is a well-known RNA modification that can affect mRNA stability and translation (Yue et al., Genes Dev. 2015). In mammals, the m6A writer is a multicomponent complex composed of the two methyltransferases METTL3 and METTL14 and ...
FAZI, Francesco, Larivera, S., Cruciani, S., BOZZONI, Irene, CAPUANO, ERNESTINA, SORCI, MELISSA, FATICA, Alessandro   +6 more
core  

The cellular m⁶A machinery.

, 2017
N6-methyladenosine (m6A) is a reversible RNA modification that occurs in cellular and viral RNA. The deposition of m6A at the consensus motif DRAmCH (where D = G/A/U, R = G > A, and H = U/C/A) is governed by a cellular methyltransferase complex composed ...
Nandan S. Gokhale (3826942), Stacy M. Horner (178713)   +1 more
core   +1 more source

m6A RNA Modification Controls Cell Fate Transition in Mammalian Embryonic Stem Cells [PDF]

, 2014
SummaryN6-methyl-adenosine (m6A) is the most abundant modification on messenger RNAs and is linked to human diseases, but its functions in mammalian development are poorly understood.
Molinie, Benoit, Wang, Jinkai, Lim, Kok Seong, Wernig, Marius, Bouley, Donna M., Xing, Yi, Zhang, Jiajing, Dedon, Peter C, Zhou, Chan, Chang, Howard Y., Giallourakis, Cosmas C., Li, Lingjie, Batista, Pedro J., Daneshvar, Kaveh, Flynn, Ryan A., Lujan, Ernesto, Carter, Ava C., Haddad, Bahareh, Qu, Kun, Mullen, Alan C.   +19 more
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Table_1_Dynamic m6A mRNA Methylation Reveals the Role of METTL3/14-m6A-MNK2-ERK Signaling Axis in Skeletal Muscle Differentiation and Regeneration.XLSX

, 2021
N6-methyladenosine (m6A) RNA methylation has emerged as an important factor in various biological processes by regulating gene expression. However, the dynamic profile, function and underlying molecular mechanism of m6A modification during skeletal ...
Shuang Tao (11510260), Yan-Xia Hu (11510263), Zhen-Dong Xiao (11510269), Yu-Jia Sun (480815), Jie-Hua He (11510257), Ya-Rui Hou (11510266), Yan-Wen Peng (9665790), Hang Lei (668450), Jian-You Liao (248971), Li-Ting Diao (4282033), Bing Yang (142278), Qi Zhang (28502), Shu-Juan Xie (191702)   +12 more
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DLST Succinylation‐Mediated Mitochondrial Metabolic Remodeling and Cuproptosis Resistance Promote Malignant Progression of Lung Adenocarcinoma

Advanced Science, EarlyView.
The DLST K409 succinylation mediated by CPT1A promotes OXPHOS and redox homeostasis through regulating enzyme activity, thereby promoting the malignant progression of LUAD. Notably, the succinylation of DLST can enhance the cuproptosis resistance by inhibiting its lipoylation.
Xuanxuan Li, Peijun Zhou, Xingzhi Peng, Qixin Liu, Wenhui Zeng, Rui Wang, Liangfang Shen, Jinwu Peng, Qin Zhou, Lifang Yang   +9 more
wiley   +1 more source

m6A potentiates Sxl alternative pre-mRNA splicing for robust Drosophila sex determination [PDF]

, 2016
N6-methyladenosine (m6A) is the most common internal modification of eukaryotic messenger RNA (mRNA) and is decoded by YTH domain proteins1, 2, 3, 4, 5, 6, 7.
Nigel P. Mongan, Sanchez-Moran, Eugenio, Sanchez-Moran, E., Haussmann, Irmgard U., Nathan Archer, Archer, N., Bodi, Zsuzsanna, Fray, R. G., Rupert G. Fray, Soller, M., Mongan, Nigel P., Archer, Nathan, Irmgard U. Haussmann, Fray, Rupert G., Sanchez-Moran, Eugenio; id_orcid, Zsuzsanna Bodi, Eugenio Sanchez-Moran, Bodi, Z., Soller, Matthias, Haussmann, Irmgard, Mongan, N. P., Matthias Soller   +21 more
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