Results 111 to 120 of about 1,875,792 (320)

An integrated whole genome analysis of Mycobacterium tuberculosis reveals insights into relationship between its genome, transcriptome and methylome. [PDF]

, 2019
Human tuberculosis disease (TB), caused by Mycobacterium tuberculosis (Mtb), is a complex disease, with a spectrum of outcomes. Genomic, transcriptomic and methylation studies have revealed differences between Mtb lineages, likely to impact on ...
A Fallow, A Hénaut, A Roetzer, A Stamatakis, AC Crampin, AC Nica, AD Tischler, AM Bolger, CU Koser, DW Huang, ED Benavente, F Coll, G Li, G Rose, H Li, I Parwati, J Casadesús, J Phelan, J Quigley, JE Galagan, K Winglee, L Zhu, M Coscolla, M Merker, MB Reed, MD Robinson, MM Suzuki, P Domenech, P Kumar, Q Gao, R Balbontín, R Brosch, R Colangeli, R Hershberg, R Pandey, R Sinha, RJC Balhana, S Adhikari, S Anders, S Homolka, S Turkarslan, SK Ahn, SS Shell, T Cortes, T Oshima   +44 more
core   +3 more sources

m6A modification–mediated lncRNA TP53TG1 inhibits gastric cancer progression by regulating CIP2A stability

Cancer Science, 2022
Long noncoding RNAs (lncRNAs) are associated with various types of cancer. However, the precise roles of many lncRNAs in tumor progression remain unclear.
D. Fang, Xinde Ou, K. Sun, Xingyu Zhou, Youpei Li, Peng-ke Shi, Zirui Zhao, Yulong He, Jian-jun Peng, Jianbo Xu   +9 more
semanticscholar   +1 more source

Exploring the role of m6A modification in the great obstetrical syndromes

The Journal of Maternal-Fetal & Neonatal Medicine, 2023
N6-methyladenosine (m6A) is one of the predominant RNA epigenetic modifications that modify RNAs reversibly and dynamically by "writers" (methyltransferase), "erasers" (demethylase), and "readers."This review aimed to provide a comprehensive understanding of the complexity of m6A regulation in the great obstetrical syndromes to understand its ...
Jie, Ning, Jie, Yan, Huixia, Yang
openaire   +2 more sources

N4‐acetylcytidine in LncRNA Gm26917 Promotes Translation in Female Germline Stem Cells by Recruiting Ribosomal Protein mRNA via EEF1A1

Advanced Science, EarlyView.
This work establishes that ac4C modification on lncRNA Gm26917 governs its spatial interactions with Rpl10 mRNA, and RBP EEF1A1 mediates the interaction between Gm26917 and Rpl10. It elucidates a novel ac4C‐Gm26917‐EEF1A1‐Rpl10 axis in FGSC maintenance both in vitro and in vivo, and provides a potential molecular target for modulating germ cell ...
Xinyue Li, Xiaopeng Hu, Ji Wu
wiley   +1 more source

Identification of m6A Regulator-Associated Methylation Modification Clusters and Immune Profiles in Melanoma

Frontiers in Cell and Developmental Biology, 2021
RNA N6-methyladenosine (m6A) modification in tumorigenesis and progression has been highlighted and discovered in recent years. However, the molecular and clinical implications of m6A modification in melanoma tumor microenvironment (TME) and immune ...
Fengying Du, Fengying Du, Fengying Du, Han Li, Yan Li, Yang Liu, Yang Liu, Xinyu Li, Ningning Dang, Qingqing Chu, Jianjun Yan, Zhen Fang, Hao Wu, Hao Wu, Zihao Zhang, Zihao Zhang, Xingyu Zhu, Xiaokang Li   +17 more
doaj   +1 more source

m^6A RNA methylation promotes XIST-mediated transcriptional repression [PDF]

, 2016
The long non-coding RNA X-inactive specific transcript (XIST) mediates the transcriptional silencing of genes on the X chromosome. Here we show that, in human cells, XIST is highly methylated with at least 78 N^6-methyladenosine (m^6A) residues—a ...
A Minajigi, A Wutz, A Wutz, AJ Link, AM Hartmann, Amy Chow, B Linder, B Moindrot, Brian F. Pickering, C Chu, CA McHugh, Chun-Kan Chen, CM Wei, Constanza Jackson, CR Alarcón, D Dominissini, Deepak P. Patil, F Ramírez, FL Wilkinson, G Jia, G Singh, GD Penny, H Uranishi, I Huppertz, J Kochan, J König, J Schindelin, J Zhao, JA Bokar, JM Engreitz, K Horiuchi, K Morohashi, K Plath, KD Meyer, KD Meyer, KD Meyer, L Berglund, L Bylund, Mitchell Guttman, MJ Cowley, N Liu, P Shannon, Q Cao, S Geula, S Heinz, S Niranjanakumari, S Schwartz, S Zhong, Samie R. Jaffrey, SC Kwon, SD Agarwala, SM Weyn-Vanhentenryck, W Ma, W Xiao, X Wang, X Wang, XL Ping, Y Hasegawa, YC Lin   +58 more
core   +2 more sources

Targeting m6A Reader YTHDF1 Enhances Antitumor Immunity and Potentiates Anti‐PD‐L1 Efficacy in Intrahepatic Cholangiocarcinoma

Advanced Science, EarlyView.
The m6A reader YTHDF1 drives intrahepatic cholangiocarcinoma (ICC) progression by remodeling the tumor immune microenvironment. YTHDF1 promotes MDSC recruitment via activation of m6A‐FOSL2‐CXCL6/CXCR2 axis, thereby suppressing CD8+ T cell infiltration and function.
Li Luo, Ziqin Liu, Zimin Song, Dong Zhang, Cong Liang, Fei Fang, Kai Lei, Lina Wang, Weikang Chen, Shunli Shen, Ming Kuang, Xiaoxing Li, Jun Yu, Shiyan Wang, Lixia Xu   +14 more
wiley   +1 more source

Functional Implications of Active N6-Methyladenosine in Plants

Frontiers in Cell and Developmental Biology, 2020
N6-methyladenosine (m6A) is the most common type of eukaryotic mRNA modification and has been found in many organisms, including mammals, and plants. It has important regulatory effects on RNA splicing, export, stability, and translation.
Hongxiang Zheng, Simin Li, Xiansheng Zhang, Na Sui   +3 more
doaj   +1 more source

Structure and regulation of ZCCHC4 in m6A-methylation of 28S rRNA. [PDF]

, 2019
N6-methyladenosine (m6A) modification provides an important epitranscriptomic mechanism that critically regulates RNA metabolism and function. However, how m6A writers attain substrate specificities remains unclear. We report the 3.1 Å-resolution crystal
Gao, Linfeng, Huang, Mengjiang, Li, Dongxu, Lu, Jiuwei, Ren, Wendan, Song, Jikui, Wang, Gang Greg   +6 more
core  

Role of FTO in adipocyte development and function: recent insights [PDF]

, 2015
In 2007, FTO was identified as the first genome-wide association study (GWAS) gene associated with obesity in humans. Since then, various animal models have served to establish the mechanistic basis behind this association.
Merkestein, Myrte, Sellayah, Dyan
core   +2 more sources