Results 1 to 10 of about 54,300 (231)

TTP protects against acute liver failure by regulating CCL2 and CCL5 through m6A RNA methylation

JCI Insight, 2021
Tristetraprolin (TTP), an important immunosuppressive protein regulating mRNA decay through recognition of the AU-rich elements (AREs) within the 3′-UTRs of mRNAs, participates in the pathogenesis of liver diseases.
Pingping Xiao, Mingxuan Li, Mengsi Zhou, Xuejun Zhao, Cheng Wang, Jinglin Qiu, Qian Fang, Hong Jiang, Huifen Dong, Rui Zhou   +9 more
doaj   +1 more source

m6A modification of a 3′ UTR site reduces RME1 mRNA levels to promote meiosis

Nature Communications, 2019
Ime4p is a yeast N6-methyladenosine (m6A) methyltransferase with an unknown role in meiosis. Rme1p is a repressor of meiosis. Here the authors show that Ime4p methylates RME1 3′ UTR to reduce its expression and enable meiosis, thus providing an example ...
G. Guy Bushkin, David Pincus, Jeffrey T. Morgan, Kris Richardson, Caroline Lewis, Sze Ham Chan, David P. Bartel, Gerald R. Fink   +7 more
doaj   +1 more source

m6A Regulates Neurogenesis and Neuronal Development by Modulating Histone Methyltransferase Ezh2

Genomics, Proteomics & Bioinformatics, 2019
N6-methyladenosine (m6A), catalyzed by the methyltransferase complex consisting of Mettl3 and Mettl14, is the most abundant RNA modification in mRNAs and participates in diverse biological processes.
Junchen Chen, Yi-Chang Zhang, Chunmin Huang, Hui Shen, Baofa Sun, Xuejun Cheng, Yu-Jie Zhang, Yun-Gui Yang, Qiang Shu, Ying Yang, Xuekun Li   +10 more
doaj   +1 more source

A Linear Regression Predictor for Identifying N6-Methyladenosine Sites Using Frequent Gapped K-mer Pattern

Molecular Therapy: Nucleic Acids, 2019
N6-methyladenosine (m6A) is one of the most common and abundant modifications in RNA, which is related to many biological processes in humans. Abnormal RNA modifications are often associated with a series of diseases, including tumors, neurogenic ...
Y.Y. Zhuang, H.J. Liu, X. Song, Y. Ju, H. Peng   +4 more
doaj   +1 more source

Cannabinoids shift the basal ganglia microRNA m6A methylation profile towards an anti-inflammatory phenotype in SIV-infected rhesus macaques

Communications Biology
Epitranscriptomic modifications [N6-methyladenosine (m6A)] regulate various diseases, including cancer and inflammation. Despite their functional relevance in neural development and differentiation, the role of m6A modifications in HIV neuropathogenesis ...
Chioma M. Okeoma, Lakmini S. Premadasa, Chen S. Tan, Ionita C. Ghiran, Mahesh Mohan   +4 more
doaj   +1 more source

METTL14 Promotes Lipid Synthesis in Dairy Goat Mammary Epithelial Cells by Targeting CEBPB via m6A-YTHDF1/3-Dependent Manner

Animals
N6-methyladenosine (m6A), a predominant and reversible modification of mammalian RNA, plays a critical role in regulating growth, development, and metabolism.
Hongyun Jiao, Lu Zhu, Xinyu Tang, Ping Gong, Wei Wang, Baolong Liu, Jun Luo   +6 more
doaj   +1 more source

AI techniques have facilitated the understanding of epitranscriptome distribution

Cell Genomics
N6-methyladenosine (m6A), the most prevalent internal mRNA modification in higher eukaryotes, plays diverse roles in cellular regulation. By incorporating both sequence- and genome-derived features, Fan et al.1 designed a novel Transformer-BiGRU ...
Daiyun Huang, Jia Meng, Kunqi Chen
doaj   +1 more source

Editorial: Emerging roles of N6-methyladenosine (m6A) modifications in endocrine disorders. [PDF]

Front Endocrinol (Lausanne), 2023
Bu P, Asadipooya K.
europepmc   +1 more source

CTSS and CD53: Emerging m6A methylation markers in diabetic kidney disease pathogenesis and their clinical implications

BMC Nephrology
Objective Diabetic kidney disease (DKD) is increasingly recognized as a leading cause of chronic kidney disease (CKD) worldwide. Although N6-methyladenosine (m6A) mRNA modification is abundant in eukaryotes, its specific contribution to DKD pathogenesis ...
Meng Leilei, Huang Bin, Li Rui, Wenjie Wen   +3 more
doaj   +1 more source

m6A demethylase FTO promotes the progression of abdominal aortic aneurysm through PDK4-mediated apoptosis

Scientific Reports
N6-methyladenosine (m6A) is one of the most abundant methylation modifications in mRNA, regulating different stages of mRNA metabolism, including folding, maturation, export, translation, and decay.
Wei Gong, Xue Yang, Ning Fan, Han Wang, Shengjie Fu, Yu Tian, Lei Li   +6 more
doaj   +1 more source