Results 1 to 10 of about 17,004 (119)

The implications of N6-methyladenosine (m6A) modification in esophageal carcinoma [PDF]

Molecular Biology Reports, 2023
Jian Hu, Xiaodong Teng, Jiacong Liu
exaly   +2 more sources

N6-methyladenosine RNA methylation: From regulatory mechanisms to potential clinical applications

Frontiers in Cell and Developmental Biology, 2022
Epitranscriptomics has emerged as another level of epigenetic regulation similar to DNA and histone modifications. N6-methyladenosine (m6A) is one of the most prevalent and abundant posttranscriptional modifications, widely distributed in many biological
Peipei Li, Peipei Li, Yuntao Wang, Yiwen Sun, Sanjie Jiang, Jingjing Li   +5 more
doaj   +1 more source

ALKBH5 prevents hepatocellular carcinoma progression by post-transcriptional inhibition of PAQR4 in an m6A dependent manner

Experimental Hematology & Oncology, 2023
Background N6-methyladenosine (m6A) is a prevalent modification of mRNA and is known to play important roles in tumorigenesis in many types of cancer. The function of N6-methyladenosine (m6A) RNA methylation depends on a variety of methyltransferases and
Weijian Wang, Qibo Huang, Zhibin Liao, Hongwei Zhang, Yachong Liu, Furong Liu, Xiaoping Chen, Bixiang Zhang, Yan Chen, Peng Zhu   +9 more
doaj   +1 more source

N6-methyladenosine methylation in kidney injury

Clinical Epigenetics, 2023
Multiple mechanisms are involved in kidney damage, among which the role of epigenetic modifications in the occurrence and development of kidney diseases is constantly being revealed.
Qimeng Wang, Xiaoting Fan, Qinghao Sheng, Meilin Yang, Ping Zhou, Shangwei Lu, Ying Gao, Zhijuan Kong, Ning Shen, Zhimei Lv, Rong Wang   +10 more
doaj   +1 more source

EBV Exploits RNA m6A Modification to Promote Cell Survival and Progeny Virus Production During Lytic Cycle

Frontiers in Microbiology, 2022
N6-methyladenosine (m6A) mediates various biological processes by affecting RNA stability, splicing, and translational efficiency. The roles of m6A modification in Epstein-Barr virus (EBV) infection in the lytic phase are unclear.
Yusuke Yanagi, Takahiro Watanabe, Yuya Hara, Yoshitaka Sato, Hiroshi Kimura, Takayuki Murata, Takayuki Murata   +6 more
doaj   +1 more source

Epigenetic Regulation of m6A Modifications in Human Cancer

Molecular Therapy: Nucleic Acids, 2020
N6-methyladenosine (m6A) is the most prevalent internal RNA modification, especially within eukaryotic messenger RNAs (mRNAs). m6A modifications of RNA regulate splicing, translocation, stability, and translation into proteins.
Wei Zhao, Xiaoqian Qi, Lina Liu, Shiqing Ma, Jingwen Liu, Jie Wu   +5 more
doaj   +1 more source

The importance of N6-methyladenosine modification in tumor immunity and immunotherapy

Experimental Hematology & Oncology, 2022
As the most common and abundant RNA modification in eukaryotic cells, N6-methyladenosine (m6A) modification plays an important role in different stages of tumor.
Ze Zhang, Furong Liu, Wei Chen, Zhibin Liao, Wanguang Zhang, Bixiang Zhang, Huifang Liang, Liang Chu, Zhanguo Zhang   +8 more
doaj   +1 more source

FTO-mediated cytoplasmic m6Am demethylation adjusts stem-like properties in colorectal cancer cell

Nature Communications, 2021
The demethylase FTO was shown to remove on N6-methyladenosine (m6A) and N6, 2’-O-dimethyladenosine (m6Am) modifications on RNAs. Here the authors show that FTO impedes cancer stem cell-like abilities in colorectal cancer cells through its m6Am ...
Sébastien Relier, Julie Ripoll, Hélène Guillorit, Amandine Amalric, Cyrinne Achour, Florence Boissière, Jérôme Vialaret, Aurore Attina, Françoise Debart, Armelle Choquet, Françoise Macari, Virginie Marchand, Yuri Motorin, Emmanuelle Samalin, Jean-Jacques Vasseur, Julie Pannequin, Francesca Aguilo, Evelyne Lopez-Crapez, Christophe Hirtz, Eric Rivals, Amandine Bastide, Alexandre David   +21 more
doaj   +1 more source

METTL3 Facilitates Oral Squamous Cell Carcinoma Tumorigenesis by Enhancing c-Myc Stability via YTHDF1-Mediated m6A Modification

Molecular Therapy: Nucleic Acids, 2020
N6-Methyladenosine (m6A) is the most common internal modification of eukaryotic messenger RNA (mRNA) that occurred on the N6 nitrogen of adenosine. However, the roles of m6A in oral squamous cell carcinoma (OSCC) are still elusive.
Wei Zhao, Yameng Cui, Lina Liu, Xiaozhou Ma, Xiaoqian Qi, Yue Wang, Zihao Liu, Shiqing Ma, Jingwen Liu, Jie Wu   +9 more
doaj   +1 more source

Systematic comparison of tools used for m6A mapping from nanopore direct RNA sequencing

Nature Communications, 2023
Direct RNA sequencing using nanopore platform can be used to detect N6-methyladenosine (m6A) modifications on mRNAs. Here the authors systematically compare tools used for m6A detection from nanopore direct sequencing.
Zhen-Dong Zhong, Ying-Yuan Xie, Hong-Xuan Chen, Ye-Lin Lan, Xue-Hong Liu, Jing-Yun Ji, Fu Wu, Lingmei Jin, Jiekai Chen, Daniel W. Mak, Zhang Zhang, Guan-Zheng Luo   +11 more
doaj   +1 more source