Results 11 to 20 of about 54,300 (231)

N6-methyladenosine methylation in kidney injury

Clinical Epigenetics, 2023
Multiple mechanisms are involved in kidney damage, among which the role of epigenetic modifications in the occurrence and development of kidney diseases is constantly being revealed.
Qimeng Wang, Xiaoting Fan, Qinghao Sheng, Meilin Yang, Ping Zhou, Shangwei Lu, Ying Gao, Zhijuan Kong, Ning Shen, Zhimei Lv, Rong Wang   +10 more
doaj   +2 more sources

The emerging roles and mechanism of N6-methyladenosine (m6A) modifications in urologic tumours progression [PDF]

Frontiers in Pharmacology, 2023
Prostate cancer (PCa), bladder cancer (BC), and renal cell cancer (RCC) are the most common urologic tumours in males. N6-methyladenosine (m6A), adenosine N6 methylation, is the most prevalent RNA modification in mammals.
Wenhao Zhu, Renshan Zhao, Xiaomin Guan, Xu Wang   +3 more
doaj   +2 more sources

N6-methyladenosine RNA methylation: From regulatory mechanisms to potential clinical applications

Frontiers in Cell and Developmental Biology, 2022
Epitranscriptomics has emerged as another level of epigenetic regulation similar to DNA and histone modifications. N6-methyladenosine (m6A) is one of the most prevalent and abundant posttranscriptional modifications, widely distributed in many biological
Peipei Li, Peipei Li, Yuntao Wang, Yiwen Sun, Sanjie Jiang, Jingjing Li   +5 more
doaj   +1 more source

ALKBH5 prevents hepatocellular carcinoma progression by post-transcriptional inhibition of PAQR4 in an m6A dependent manner

Experimental Hematology & Oncology, 2023
Background N6-methyladenosine (m6A) is a prevalent modification of mRNA and is known to play important roles in tumorigenesis in many types of cancer. The function of N6-methyladenosine (m6A) RNA methylation depends on a variety of methyltransferases and
Weijian Wang, Qibo Huang, Zhibin Liao, Hongwei Zhang, Yachong Liu, Furong Liu, Xiaoping Chen, Bixiang Zhang, Yan Chen, Peng Zhu   +9 more
doaj   +1 more source

EBV Exploits RNA m6A Modification to Promote Cell Survival and Progeny Virus Production During Lytic Cycle

Frontiers in Microbiology, 2022
N6-methyladenosine (m6A) mediates various biological processes by affecting RNA stability, splicing, and translational efficiency. The roles of m6A modification in Epstein-Barr virus (EBV) infection in the lytic phase are unclear.
Yusuke Yanagi, Takahiro Watanabe, Yuya Hara, Yoshitaka Sato, Hiroshi Kimura, Takayuki Murata, Takayuki Murata   +6 more
doaj   +1 more source

The importance of N6-methyladenosine modification in tumor immunity and immunotherapy

Experimental Hematology & Oncology, 2022
As the most common and abundant RNA modification in eukaryotic cells, N6-methyladenosine (m6A) modification plays an important role in different stages of tumor.
Ze Zhang, Furong Liu, Wei Chen, Zhibin Liao, Wanguang Zhang, Bixiang Zhang, Huifang Liang, Liang Chu, Zhanguo Zhang   +8 more
doaj   +1 more source

Epigenetic Regulation of m6A Modifications in Human Cancer

Molecular Therapy: Nucleic Acids, 2020
N6-methyladenosine (m6A) is the most prevalent internal RNA modification, especially within eukaryotic messenger RNAs (mRNAs). m6A modifications of RNA regulate splicing, translocation, stability, and translation into proteins.
Wei Zhao, Xiaoqian Qi, Lina Liu, Shiqing Ma, Jingwen Liu, Jie Wu   +5 more
doaj   +1 more source

Exploring the role of m6A modification in the great obstetrical syndromes

The Journal of Maternal-Fetal & Neonatal Medicine, 2023
Background N6-methyladenosine (m6A) is one of the predominant RNA epigenetic modifications that modify RNAs reversibly and dynamically by “writers” (methyltransferase), “erasers” (demethylase), and “readers.”Objective This review aimed to provide a ...
Jie Ning, Jie Yan, Huixia Yang
doaj   +1 more source

FTO-mediated cytoplasmic m6Am demethylation adjusts stem-like properties in colorectal cancer cell

Nature Communications, 2021
The demethylase FTO was shown to remove on N6-methyladenosine (m6A) and N6, 2’-O-dimethyladenosine (m6Am) modifications on RNAs. Here the authors show that FTO impedes cancer stem cell-like abilities in colorectal cancer cells through its m6Am ...
Sébastien Relier, Julie Ripoll, Hélène Guillorit, Amandine Amalric, Cyrinne Achour, Florence Boissière, Jérôme Vialaret, Aurore Attina, Françoise Debart, Armelle Choquet, Françoise Macari, Virginie Marchand, Yuri Motorin, Emmanuelle Samalin, Jean-Jacques Vasseur, Julie Pannequin, Francesca Aguilo, Evelyne Lopez-Crapez, Christophe Hirtz, Eric Rivals, Amandine Bastide, Alexandre David   +21 more
doaj   +1 more source

The role of N6-methyladenosine (m6A) in kidney diseases [PDF]

, 2023
Chemical modifications are a specific and efficient way to regulate the function of biological macromolecules. Among them, RNA molecules exhibit a variety of modifications that play important regulatory roles in various biological processes.
Binjian Wang, Lan Yuan, Haoran Chen, Yumeng Lin, Zhongyu Han, Liuyan Chen, Luling You, Yiyue Fan, Yanmei Wang, Yue Ma, Ji Luo, Fang Peng, Meiqi Zhang   +12 more
core   +1 more source