Results 11 to 20 of about 23,000 (243)
The implications of N6-methyladenosine (m6A) modification in esophageal carcinoma. [PDF]
Mol Biol Rep, 2023 AbstractEsophageal carcinoma (EC) is always diagnosed at advanced stage and its the mortality rate remains high. The patients usually miss the best opportunity for treatment because of non-specific symptoms and the survival rates are low. N6-methyladenosine (m6A) the predominant modification in eukaryotic messenger RNA(mRNA), serves vital roles in ...
He C +7 more
europepmc +3 more sources
The therapeutic targets of N6-methyladenosine (m6A) modifications on tumor radioresistance. [PDF]
Discov Oncol, 2023 AbstractRadiation therapy is an important tool for malignant tumors, and its tolerance needs to be addressed. In recent years, several studies have shown that regulators of aberrant m6A methylation play an important role in the formation, development and invasion and metastasis of tumors.
Zhang Y, Gu W, Shao Y.
europepmc +4 more sources
Potential roles of N6-methyladenosine (m6A) in immune cells [PDF]
Journal of Translational Medicine, 2021 AbstractN6-methyl-adenosine (m6A) is one of the most common internal modifications on RNA molecules present in mammalian cells. Deregulation of m6A modification has been recently implicated in many types of human diseases. Therefore, m6A modification has become a research hotspot for its potential therapeutic applications in the treatment of various ...
Chang Liu +8 more
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Editorial: Emerging roles of N6-methyladenosine (m6A) modifications in endocrine disorders. [PDF]
Front Endocrinol (Lausanne), 2023 Bu P, Asadipooya K.
europepmc +4 more sources
Emerging Roles of N6-Methyladenosine (m6A) Epitranscriptomics in Toxicology [PDF]
Toxicological Sciences, 2021 Abstract Epitranscriptomics, the study of chemically modified RNAs, is a burgeoning field being explored in a variety of scientific disciplines. Of the currently known epitranscriptomic modifications, N6-methyladenosine (m6A) methylation is the most abundant.
Malovic, Emir +3 more
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Regulatory Role of N6-Methyladenosine (m6A) Modification in Osteoarthritis. [PDF]
Front Cell Dev Biol, 2022 Osteoarthritis (OA) is the most common joint disease, usually occurring in middle-aged and elderly people. However, current treatment for OA in its early stages is ineffective, and drug therapy is often ineffective in slowing the progression of the disease.
Zhai G +7 more
europepmc +4 more sources
Insights into the role of N6-methyladenosine (m6A) in plant-virus interactions. [PDF]
J VirolABSTRACT N6-methyladenosine (m6A) is a common and dynamic epitranscriptomic modification in eukaryotic RNAs, affecting stability, splicing, translation, and degradation. Recent technological advancements have revealed the complex nature of m6A modifications, highlighting their importance in plant and animal species ...
Secco N, Sheikh AH, Hirt H.
europepmc +4 more sources
Influence of N6-methyladenosine (m6A) modification on cell phenotype in Alzheimer's disease. [PDF]
PLoS One, 2023 ObjectiveRecent research has suggested that m6A modification takes on critical significance to Neurodegeneration. As indicated by the genome-wide map of m6A mRNA, genes in Alzheimer’s disease model achieved significant m6A methylation. This study aimed to investigate the hub gene and pathway of m6A modification in the pathogenesis of AD.
Ni P, Pan K, Zhao B.
europepmc +3 more sources
Regulatory Role of N6-methyladenosine (m6A) Modification in Osteosarcoma [PDF]
Frontiers in Oncology, 2021 Osteosarcoma is the most common primary bone malignancy, typically occurring in childhood or adolescence. Unfortunately, the clinical outcomes of patients with osteosarcoma are usually poor because of the aggressive nature of this disease and few treatment advances in the past four decades. N6-methyladenosine (m6A) is one of the most extensive forms of
Yujie Zhang +7 more
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Impact of N6-methyladenosine (m6A) modification on immunity
Cell Communication and Signaling, 2022 AbstractN6-methyl-adenosine (m6A) is the most prevalent modification on mRNAs and long noncoding RNAs (lnRNAs) in higher eukaryotes. Modulation of m6A relies on m6A writers, erasers and readers. m6A modification contributes to diverse fundamental biological functions at the molecular, cellular, and physiological levels.
Raghda A. Elsabbagh +4 more
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