Results 21 to 30 of about 17,129 (229)

Dysregulated N6-methyladenosine (m6A) processing in hepatocellular carcinoma

Annals of Hepatology, 2021
N6-methyladenosine (m6A) is the most thoroughly studied type of internal RNA modification, as this epigenetic modification is the most abundant in eukaryotic RNAs to date. This modification occurs in various types of RNAs and plays significant roles in dominant RNA-related processes, such as translation, splicing, export and degradation.
Yue-fan Wang, Chun-mei Ge, Hao-zan Yin, Zhi-hui Dai, Jun-peng Dong, Man Ji, Fu Yang   +6 more
openaire   +3 more sources

N6-methyladenosine (m6A) RNA modification in cancer stem cells [PDF]

Stem Cells, 2020
Abstract Cancer stem cells (CSCs), a unique subset of undifferentiated cells with stem cell-like properties, have emerged as driving forces in mediating tumor growth, metastasis, and therapeutic resistance. Recent advances have highlighted that N6-methyladenosine (m6A) RNA modification plays an important role in cancer biology and CSCs ...
Zhonghua Ma, Jiafu Ji
openaire   +2 more sources

The emerging roles of N6-methyladenosine (m6A) deregulation in liver carcinogenesis [PDF]

Molecular Cancer, 2020
AbstractLiver cancer is a common cancer worldwide. Although the etiological factors of liver carcinogenesis are well defined, the underlying molecular mechanisms remain largely elusive. Epigenetic deregulations, such as aberrant DNA methylation and histone modifications, play a critical role in liver carcinogenesis.
Mengnuo Chen, Chun-Ming Wong
openaire   +3 more sources

N6-methyladenosine (m6A) modification and its clinical relevance in cognitive dysfunctions [PDF]

Aging, 2021
N6 adenosine methylation (m6A) is the most abundant internal RNA modification in eukaryotic cells. Dysregulation of m6A has been associated with the perturbations of cell proliferation and cell death in different diseases. However, the roles of m6A in the neurodegenerative process and cognitive dysfunction are unclear.We systematically investigated the
Du, Bingying, Zhang, Yanbo, Liang, Meng, Du, Zengkan, Li, Haibo, Fan, Cunxiu, Zhang, Hailing, Jiang, Yan, Bi, Xiaoying   +8 more
openaire   +2 more sources

The emerging roles of N6-methyladenosine (m6A) deregulation in polycystic ovary syndrome. [PDF]

J Ovarian Res
Abstract Polycystic ovary syndrome (PCOS) is an endocrine metabolic syndrome characterized by ovulation disorders, hyperandrogenemia, and polycystic ovaries, which seriously affect the psychological and physical health of childbearing women. N6-methyladenosine (m6A), as the most common mRNA epigenetic modification in eukaryotes, is vital for ...
Jiang L, Xiao J, Xie L, Zheng F, Ge F, Zhao X, Qiang R, Fang J, Liu Z, Xu Z, Chen R, Wang D, Liu Y, Xia Q.   +13 more
europepmc   +4 more sources

N6-methyladenosine (m6A) RNA modification in fibrosis and collagen-related diseases. [PDF]

Clin Epigenetics
Fibrosis is an abnormal tissue healing process characterized by the excessive accumulation of ECM components, such as COL I and COL III, in response to tissue injury or chronic inflammation. Recent advances in epitranscriptomics have underscored the importance of m6A modification in fibrosis.
Tan M, Liu S, Liu L.
europepmc   +4 more sources

N6-methyladenosine (m6A) modification in inflammation: a bibliometric analysis and literature review. [PDF]

PeerJ
N6-methyladenosine (m6A) is the most abundant internal messenger RNA modification in eukaryotes, influencing various physiological and pathological processes by regulating RNA metabolism. Numerous studies have investigated the role of m6A in inflammatory responses and inflammatory diseases.
Li Z, Lao Y, Yan R, Guan X, Bai Y, Li F, Dong Z.   +6 more
europepmc   +5 more sources

m6A-mRNA Methylation Regulates Gene Expression and Programmable m6A Modification of Cellular RNAs With CRISPR-Cas13b in Renal Cell Carcinoma

Frontiers in Genetics, 2022
Background: N6-methyladenosine (m6A) is the most extensive messenger RNA modification. Despite recent advances in the biological roles of m6A, its role in the development and progression of renal cell carcinoma (RCC) remains unclear.Methods: In this ...
Ying Gan, Ying Gan, Aolin Li, Aolin Li, Jun Liu, Jun Liu, Xiaofei Wang, Xiaofei Wang, Zhenan Zhang, Zhenan Zhang, Qinhan Li, Qinhan Li, Xiongjun Ye, Xiongjun Ye, Lin Yao, Lin Yao, Qian Zhang, Qian Zhang   +17 more
doaj   +1 more source

N6-Methyladenosine modification: a novel pharmacological target for anti-cancer drug development

Acta Pharmaceutica Sinica B, 2018
N6-Methyladenosine (m6A) modification is the most pervasive modification of human mRNA molecules. It is reversible via regulation of m6A modification methyltransferase, demethylase and proteins that preferentially recognize m6A modification as “writers”,
Yi Niu, Arabella Wan, Ziyou Lin, Xiongbin Lu, Guohui Wan   +4 more
doaj   +1 more source

A neural m6A/Ythdf pathway is required for learning and memory in Drosophila

Nature Communications, 2021
Epitranscriptomic modifications can regulate learning and memory. Here, the authors provide proteomic and functional analysis of N6-methyladenosine (m6A)-binding proteins in D.
Lijuan Kan, Stanislav Ott, Brian Joseph, Eun Sil Park, Wei Dai, Ralph E. Kleiner, Adam Claridge-Chang, Eric C. Lai   +7 more
doaj   +1 more source