Results 41 to 50 of about 16,939 (196)
YTHDF2 promotes mitotic entry and is regulated by cell cycle mediators.
PLoS Biology, 2020 The N6-methyladenosine (m6A) modification regulates mRNA stability and translation. Here, we show that transcriptomic m6A modification can be dynamic and the m6A reader protein YTH N6-methyladenosine RNA binding protein 2 (YTHDF2) promotes mRNA decay ...
Qili Fei +4 more
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N 6 -methyladenosine regulates glycolysis of cancer cells through PDK4
Nature Communications, 2020 Dysregulation of N6-Methyladenosine (m6A) is associated with cancer progression. Here, authors show that m6A methylation of pyruvate dehydrogenase kinase 4 (PDK4) positively regulates its mRNA stability and translation, and consequently affects ...
Zihan Li +7 more
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Roles of RNA m6A modifications in plant-virus interactions
Stress Biology, 2023 Viral RNAs have been known to contain N6-methyladenosine (m6A) modifications since the 1970s. The function of these modifications remained unknown until the development of genome-wide methods to map m6A residues. Increasing evidence has recently revealed
Hao He +4 more
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N6-methyladenosine (m6A) recruits and repels proteins to regulate mRNA homeostasis [PDF]
Nature Structural & Molecular Biology, 2017 RNA modifications are integral to the regulation of RNA metabolism. One abundant mRNA modification is N6-methyladenosine (m6A), which affects various aspects of RNA metabolism, including splicing, translation and degradation. Current knowledge about the proteins recruited to m6A to carry out these molecular processes is still limited.
Raghu R Edupuganti +14 more
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N6-methyladenosine (m6A) modification in hepatocellular carcinoma
Biomedicine & PharmacotherapyHepatocellular carcinoma (HCC) is one of the deadliest cancers of human, the tumor-related death of which ranks third among the common malignances. N6-methyladenosine (m6A) methylation, the most abundant internal modification of RNA in mammals, participates in the metabolism of mRNA and interrelates with ncRNAs. In this paper, we overviewed the complex
Hehua Ma +12 more
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A novel N6-methyladenosine (m6A)-dependent fate decision for the lncRNA THOR [PDF]
Cell Death & Disease, 2020 AbstractPrevious studies have revealed the critical roles of the N6-methyladenosine (m6A) modification of long non-coding RNAs (lncRNAs) in cancers, but the relationship between the oncogenic role of the lncRNATHOR(a representative of cancer/testis lncRNAs) and m6A modification remains unclear.
Liu, Hongmei +5 more
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An oncopeptide regulates m6A recognition by the m6A reader IGF2BP1 and tumorigenesis
Nature Communications, 2020 The involvement of long non-coding RNA (lncRNA) in the regulation of N6-methyladenosine (m6A) modification of RNA is unclear. Here, the authors show that LINC00266-1 encodes a peptide that binds to m6A reader, IGF2BP1 to enhance the recognition of m6A ...
Song Zhu +9 more
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Inducible and reversible RNA N6-methyladenosine editing
Nature Communications, 2022 RNA modifications, including N6-methyladenosine (m6A), have been reported to regulate fundamental RNA processes and properties, and directly linked to various human diseases.
Huaxia Shi +4 more
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Frontiers in Pharmacology, 2023 Prostate cancer (PCa), bladder cancer (BC), and renal cell cancer (RCC) are the most common urologic tumours in males. N6-methyladenosine (m6A), adenosine N6 methylation, is the most prevalent RNA modification in mammals.
Wenhao Zhu +3 more
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Emerging roles of N6-methyladenosine (m6A) modification in breast cancer [PDF]
Cell & Bioscience, 2020 AbstractN6-Methyladenosine (m6A) is the most abundant, dynamic, and reversible epigenetic RNA modification that is found in coding and non-coding RNAs. Emerging studies have shown that m6A and its regulators affect multiple steps in RNA metabolism and play broad roles in various cancers.
Yanyan Wang +5 more
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