Results 41 to 50 of about 23,000 (243)

Yeast m6 A methylated mRNAs are enriched on translating ribosomes during meiosis, and under rapamycin treatment [PDF]

, 2015
Interest in mRNA methylation has exploded in recent years. The sudden interest in a 40 year old discovery was due in part to the finding of FTO’s (Fat Mass Obesity) N6-methyladenosine (m6 A) deaminase activity, thus suggesting a link between obesity ...
Archer, Nathan, Bodi, Zsuzsanna, Bottley, Andrew, Fray, Rupert G., May, Sean, May, Sean T.   +5 more
core   +3 more sources

Direct RNA sequencing reveals m6A modifications on adenovirus RNA are necessary for efficient splicing

Nature Communications, 2020
Adenovirus transcripts contain N6-methyladenosine (m6A) modification. Here the authors profile m6A modification sites on adenovirus mRNAs using Illumina meRIP-Seq and nanopore direct RNA sequencing, and showcase a role for m6A in splicing of viral late ...
Alexander M. Price, Katharina E. Hayer, Alexa B. R. McIntyre, Nandan S. Gokhale, Jonathan S. Abebe, Ashley N. Della Fera, Christopher E. Mason, Stacy M. Horner, Angus C. Wilson, Daniel P. Depledge, Matthew D. Weitzman   +10 more
doaj   +1 more source

Comprehensive Analysis of N6-methyladenosine Modification Patterns Associated With Multiomic Characteristics of Bladder Cancer

Frontiers in Medicine, 2021
Purpose: To comprehensively analyze N6-methyladenosine modification patterns in bladder tumors and to further systematically explore the inherent relationships between these modification patterns and multiomic tumor characteristics.Materials and Methods:
Jingchao Liu, Jingchao Liu, Jianlong Wang, Meng Wu, Wei Zhang, Wei Zhang, Lingfeng Meng, Lingfeng Meng, Jiawen Wang, Jiawen Wang, Zhengtong Lv, Zhengtong Lv, Haoran Xia, Haoran Xia, Yaoguang Zhang, Yaoguang Zhang, Jianye Wang, Jianye Wang   +17 more
doaj   +1 more source

Zc3h13/Flacc is required for adenosine methylation by bridging the mRNA binding factor Rbm15/Spenito to the m6A machinery component Wtap/Fl(2)d [PDF]

, 2018
N6-methyladenosine (m6A) is the most abundant mRNA modification in eukaryotes, playing crucial roles in multiple biological processes. m6A is catalyzed by the activity of Mettl3, which depends on additional proteins whose precise functions remain poorly ...
Andrade-Navarro, Miguel A., Biggiogera, Marco, Bühler, Marc, Carl, Sarah H., Hares, Tina, Haussmann, Irmgard, Helm, Mark, Hess, Daniel, Jacob, Dominik, Knuckles, Philip, Kreim, Nastasja, Lence, Tina, Masiello, Irene, Roignant, Jean-Yves, Soller, Matthias, Villaseñor, Rodrigo   +15 more
core   +4 more sources

Functional organization of box C/D RNA-guided RNA methyltransferase [PDF]

, 2020
Box C/D RNA protein complexes (RNPs) catalyze site-specific 2'-O-methylation of RNA with specificity determined by guide RNAs. In eukaryotic C/D RNP, the paralogous Nop58 and Nop56 proteins specifically associate with terminal C/D and internal C'/D ...
Huang, Lin, Lilley, David M. J., Wang, Jiayin, Yang, Zuxiao, Ye, Keqiong   +4 more
core   +2 more sources

Role of N6-Methyladenosine (m6A) Methylation Regulators in Hepatocellular Carcinoma [PDF]

Frontiers in Oncology, 2021
Liver cancer is the fifth most common malignant tumor in terms of incidence and the third leading cause of cancer-related mortality globally. Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer. Although great progress has been made in surgical techniques, hepatic artery chemoembolization, molecular targeting and ...
Nanfang Qu, Xiaotong Bo, Bin Li, Lei Ma, Feng Wang, Qinghua Zheng, Xuhua Xiao, Fengmei Huang, Yuanyuan Shi, Xuemei Zhang   +9 more
openaire   +3 more sources

N 6-methyladenosine RNA modification suppresses antiviral innate sensing pathways via reshaping double-stranded RNA

Nature Communications, 2021
N6-methyladenosine (m6A) RNA modification regulates RNA metabolism, and has been implicated in immune regulation. Here, the authors show that the m6A methyltransferase, METTL3, translocates into the cytoplasm to increase viral RNA m6A modification ...
Weinan Qiu, Qingyang Zhang, Rui Zhang, Yangxu Lu, Xin Wang, Huabin Tian, Ying Yang, Zijuan Gu, Yanan Gao, Xin Yang, Guanshen Cui, Baofa Sun, Yanan Peng, Hongyu Deng, Hua Peng, Angang Yang, Yun-Gui Yang, Pengyuan Yang   +17 more
doaj   +1 more source

METTL3 is essential for postnatal development of brown adipose tissue and energy expenditure in mice

Nature Communications, 2020
N6-methyladenosine (m6A) is one of the most prevalent mRNA modifications in eukaryotes. Here the authors show that the m6A writer protein methyltransferase-like (METTL) 3 plays an important role for the development of brown adipose tissue.
Yuqin Wang, Ming Gao, Fuxing Zhu, Xinzhi Li, Ying Yang, Qiuxin Yan, Linna Jia, Liwei Xie, Zheng Chen   +8 more
doaj   +1 more source

YTHDF2 promotes mitotic entry and is regulated by cell cycle mediators.

PLoS Biology, 2020
The N6-methyladenosine (m6A) modification regulates mRNA stability and translation. Here, we show that transcriptomic m6A modification can be dynamic and the m6A reader protein YTH N6-methyladenosine RNA binding protein 2 (YTHDF2) promotes mRNA decay ...
Qili Fei, Zhongyu Zou, Ian A Roundtree, Hui-Lung Sun, Chuan He   +4 more
doaj   +1 more source

Epitranscriptomics as a new layer of regulation of gene expression in skeletal muscle: known functions and future perspectives [PDF]

, 2023
Epitranscriptomics refers to post-transcriptional regulation of gene expression via RNA modifications and editing that affect RNA functions. Many kinds of modifications of mRNA have been described, among which are N6-methyladenosine (m6A), N1 ...
Alessandra Renzini, Carol Imbriano, Eleonora Maretti, Giorgia Cavioli, Silvia Belluti, Susanna Molinari, Viviana Moresi   +6 more
core   +4 more sources