Results 51 to 60 of about 54,300 (231)

Roles of RNA m6A modifications in plant-virus interactions

Stress Biology, 2023
Viral RNAs have been known to contain N6-methyladenosine (m6A) modifications since the 1970s. The function of these modifications remained unknown until the development of genome-wide methods to map m6A residues. Increasing evidence has recently revealed
Hao He, Mingxuan Jia, Jie Liu, Xueping Zhou, Fangfang Li   +4 more
doaj   +1 more source

DataSheet_1_Identification and Validation of N6-Methyladenosine-Related Biomarkers for Bladder Cancer: Implications for Immunotherapy.pdf

, 2022
N6-methyladenosine (m6A) has emerged as one of the most important modifications of RNA. Based on the expression of 23 different modes of m6A regulatory factors, we identified three different m6A modification patterns in bladder cancer. The effects of the
Hongyu Deng (104622), Ming Zhou (73279), Faqing Tang (326220), Dongyong Shan (6456368), Xingyu Chen (1938484), Ke Cao (569991)   +5 more
core   +1 more source

N6-methyladenosine (m6A) dynamics during Drosophila melanogaster neural development [PDF]

, 2022
Stem cell proliferation and differentiation is tightly regulated, and this balance is incredibly important for the health of an organism, especially in development of the central nervous system.
Sami, Josephine D
core   +1 more source

An oncopeptide regulates m6A recognition by the m6A reader IGF2BP1 and tumorigenesis

Nature Communications, 2020
The involvement of long non-coding RNA (lncRNA) in the regulation of N6-methyladenosine (m6A) modification of RNA is unclear. Here, the authors show that LINC00266-1 encodes a peptide that binds to m6A reader, IGF2BP1 to enhance the recognition of m6A ...
Song Zhu, Ji-Zhong Wang, De Chen, Yu-Tian He, Nan Meng, Min Chen, Rui-Xun Lu, Xin-Hui Chen, Xiao-Lan Zhang, Guang-Rong Yan   +9 more
doaj   +1 more source

Inducible and reversible RNA N6-methyladenosine editing

Nature Communications, 2022
RNA modifications, including N6-methyladenosine (m6A), have been reported to regulate fundamental RNA processes and properties, and directly linked to various human diseases.
Huaxia Shi, Ying Xu, Na Tian, Ming Yang, Fu-Sen Liang   +4 more
doaj   +1 more source

N6-Methyladenosine-Modified ATP8B1-AS1 Exerts Oncogenic Roles in Hepatocellular Carcinoma via Epigenetically Activating MYC

, 2023
Chuan Tan,1,* Yanyan Huang,2,* Zheng Huang,2,* Yuanjia Ning,2 Lizheng Huang,2 Xianjian Wu,1 Yuan Lu,1 Huamei Wei,3 Jian Pu1 1Department of Hepatobiliary Surgery, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise ...
Huang Y, Huang Z, Lu Y, Ning Y, Tan C, Pu J, Wei H, Huang L, Wu X   +8 more
core  

Table_1_Identification and Validation of N6-Methyladenosine-Related Biomarkers for Bladder Cancer: Implications for Immunotherapy.xlsx

, 2022
N6-methyladenosine (m6A) has emerged as one of the most important modifications of RNA. Based on the expression of 23 different modes of m6A regulatory factors, we identified three different m6A modification patterns in bladder cancer. The effects of the
Hongyu Deng (104622), Ming Zhou (73279), Faqing Tang (326220), Dongyong Shan (6456368), Xingyu Chen (1938484), Ke Cao (569991)   +5 more
core   +1 more source

RGS16 Aggravates Hepatic Ischemia‐Reperfusion Injury via Hepatocyte‐Intrinsic Apoptosis/Inflammation & Neutrophil Recruitment/NETosis

Advanced Science, EarlyView.
RGS16 competitively interferes with the YTHDF3–PAN3 complex to prevent CXCL1 mRNA decay during hepatic ischemia‐reperfusion injury. Stabilized CXCL1 strengthens hepatocyte injury, neutrophil recruitment, and NET‐associated inflammation, uncovering how stress‐induced RGS16 converts post‐transcriptional regulation into immune‐mediated liver damage ...
Xinglong Li, Zhanzhi Meng, Hongjun Yu, Yongliang Hua, Zihao Li, Bing Yin, Baolin Qian, Zhongyu Li, Yongzhi Zhou, Zhigang Feng, Shounan Lu, Shanjia Ke, Miaoyu Bai, Yao Fu, Wei Tang, Natalia V. Belosludtseva, Yong Ma   +16 more
wiley   +1 more source

Parallel functional assessment of m6A sites in human endodermal differentiation with base editor screens

Nature Communications, 2022
N6-methyladenosine (m6A) plays important role in lineage specifications of embryonic stem cells, but its role at specific sites has not been assessed. Here the authors develop an adenine editor-based strategy, and systematically identify functional m6A ...
Weisheng Cheng, Fang Liu, Zhijun Ren, Wenfang Chen, Yaxin Chen, Tianwei Liu, Yixin Ma, Nan Cao, Jinkai Wang   +8 more
doaj   +1 more source

Research progress on the role of N6-methyladenosine (m6A) RNA modification in reproductive system diseases [PDF]

, 2021
N6-methyladenosine (m6A) RNA modification is a post-transcriptional modification occurring on the 6th N atom of RNA adenine (A), regulating the structure, stability, splicing, output, translation and decay of mRNA, and thus extensively affecting the life
ZHANG Yan, ZHU Meng-wen, LIU Tong, YANG Sheng, LIANG Ge-yu
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